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Biomedical subjects

H G Bender

Publications and source records attributed to H G Bender.

At least 91 records · Page 5Linked to original sources
PubMed1991

Breast malignancy.

Risks associated with oral contraceptive use have been shown for women who begin using them before age 25 and before their first full-term pregnancy. The effectiveness of chemoprevention is being studied. Screening may reduce mortality by 30% in women aged 50 to 69. Breast-conserving lumpectomy is indicated for small tumors. In some postmenopausal node-positive patients, a combination of hormonal and chemotherapy may be useful. In metastatic breast cancer, dose-intensification of chemotherapy has been investigated. Palliative treatment involves tamoxifen. Analysis of steroid hormone receptor status involves fine-needle aspiration, enzyme immunoassay, and a new autoradiographic procedure using radiolabeled estrogens. Prognostic factors under study include oncogene amplification, urokinase plasminogen activator level, expression of growth factors and growth factor receptors, proliferation parameters such as ploidy and S-phase fraction, mutations, and cathepsin D levels.

Breast Neoplasms↗
PubMed1990

Immunohistochemical investigations of estrogen receptors in normal and neoplastic squamous epithelium of the vulva.

Atrophic disease of the vulvar epithelium can be treated with steroids, but carcinoma of the vulva cannot be influenced with any hormone therapy. Seventy-one vulvar specimens were tested for estrogen receptor (ER) content by means of immunohistochemistry. Slight ER staining was found in nonkeratinizing squamous epithelium in 17 of 22 cases. A weak ER reaction in the basal and parabasal layers was found in only 2 of 17 specimens of keratinizing squamous epithelium. However, no ER was found in any neoplastic tissue of the vulva or the adjacent stroma. The loss of ER in neoplastic cells could explain the clinical experience that antihormonal treatment of vulvar carcinomas produces no appreciable improvement.

Adolescent↗
PubMed1989

[Nonpuerperal mastitis. 3 possible causes including mammography correlates].

We present three cases of non-puerperal mastitis including the corresponding mammographies to illustrate three possible causes: mastitis with abscess, artificial mastitis and breast carcinoma. The clinic picture did not reveal the cause of mastitis. Ultrasonography and mammography should be performed early in the evaluation of non-puerperal mastitis.

Adult↗
PubMed1989

[Current therapy of vulvar cancer. Results of a survey of German university gynecologic clinics].

Treatments concepts for carcinoma of the vulva in German university clinics were surveyed in an inquiry made by letter. It was revealed that radical vulvectomy is standard therapy of invasive vulvar cancer. Patients with inguinal lymph-node metastases are treated by pelvic lymphadenectomy or radiation. Almost all clinics provide reconstructive procedures performed by a gynecologist and delineate an "early vulvar cancer" with less radical therapy. There is still some disagreement on the definition of criteria such as maximal tumor diameter and invasion.

Combined Modality Therapy↗
PubMed1989

Immunohistochemical investigations of steroid receptors in normal and neoplastic squamous epithelium of the uterine cervix.

The proliferation of squamous cells of the vagina and cervix uteri is induced by steroid hormones during the menstrual cycle. However, carcinoma of the cervix cannot be influenced by any hormone therapy. Forty-four different cervical specimens (different days in the menstrual cycle of healthy women and those with dysplastic lesions and carcinomas of the cervix) have been tested for estrogen (ER) and progesterone (PR) receptor protein content by means of immunohistochemistry. The ER content of the squamous epithelium depends upon the menstrual cycle: in the early proliferative phase cells of all layers are negative. In the midphase of proliferation the basal and parabasal layers become positive, and in the secretory phase positive cell nuclei can be found up to the superficial layers. A weak reaction to ER staining is found only in mild dysplastic lesions of the uterine cervix; severe dysplastic forms and invasive carcinomas were all negative. No positive PR was found in any squamous cell tissue. Stroma cells of the uterine cervix showed different straining intensity for ER and PR, regardless of the menstrual cycle. The loss of ER in the neoplastic cell could be an explanation for three clinical experiences: premenopausal patients have no tumor progression of the cervix uteri despite normal ovarian function; the duration of survival shows no relation to the receptor status of cervical carcinomas; and antihormonal treatment of cervical carcinomas produces no appreciable therapeutic success.

Adult↗
PubMed1988

The value of preoperative chest X-rays in gynecological patients.

We assessed the value of preoperative chest x-rays in gynecological patients. Abnormalities were noted in the chest x-rays of 10% of 1175 patients with genital or breast disorders. When the chest x-ray was abnormal, 48% of patients had no clinical features of intrathoracic disease. Abnormal chest x-ray results did not seem to have a major influence on the decision to operate or on the type of anesthesia used. In our series, probably only one patient would have received inappropriate treatment in the absence of a chest x-ray. We conclude that preoperative chest x-rays are of value in ruling out metastases in patients with a suspected neoplasm, but have little value in other circumstances.

Adult↗
PubMed1988

Breast cancer detection: age-related significance of findings on physical exam and mammography.

Data of 909 consecutive patients who underwent physical exam (PE), mammography (MG), and breast biopsy were analyzed in a retrospective study. Preoperative findings of PE and MG were classified as (1) suspicious for malignancy, (2) probably benign lesion, (3) normal and correlated with histology of the biopsy and the patient's age. Sensitivity of PE remained on a 0.9 level approximately up to age 50 and dropped to 0.78 and 0.85 respectively thereafter. Sensitivity of MG was slightly lower and was 0 in the age group 30 years and younger. Specificity of PE rose from 0.52 to 0.84 and dropped to 0.55 in women above 70 years. Specificity of MG decreased from 0.9 to 0.4 over the age groups. The relatively low positive predictive value of both PE and MG--particularly in the lower age groups--leads to an excessive rate of benign biopsies up to the age of 60. Due to suboptimal sensitivity PE and MG have to be used as a combined diagnostic modality if a reduction of breast cancer mortality is to be accomplished. Screening programs are of particular efficacy in women over 45 years of age due to age-dependent incidence figures and diagnostic sensitivity of PE and MG in this age group.

Adolescent↗
PubMed1988

[Experiences with after care of patients with breast cancer].

We retrospectively analyzed methods of follow-up and subsequent clinical outcome in 399 breast cancer patients treated with curative intent. Radioisotope liver scans, liver sonograms and laboratory investigations were of little value in detecting metastases. Mammography detected 2 of 6 contralateral breast cancers in an asymptomatic stage. Of 92 metastatic diseases, 24 were disclosed by a total of 871 radioisotope bone scans, and 17 were disclosed by a total of 2409 chest x-rays. The detection of distant metastases in an asymptomatic stage by diagnostic procedures vs detection by symptoms was not correlated with a survival benefit. The survival times for the two groups were 6.4 years vs 6.7 years (p = 0.7) after initiation of primary therapy, and 20.8 vs 20.4 months (p = 0.9) after the diagnosis of metastatic disease. Our study does not lend support to the hypothesis that the detection of metastatic disease in an asymptomatic stage or regular follow-up visits are associated with a survival benefit. We conclude that clinical history, physical examination, and mammography are the most important procedures in the follow-up of breast cancer patients.

Breast↗
PubMed1988

Human papilloma virus findings in the perimeter of vulvo-vaginal malignancies.

During recent years demonstration of human papilloma virus (HPV) in cancers of the lower female genital tract has led to the assumption, that these viruses may be associated with the pathogenesis of these tumors. This theory is particularly important for patients with intraepithelial lesions of the cervix, vagina and vulva, vulvar dystrophies and condylomata acuminata of the vulva and vagina, which are seen in the dysplasia clinic of our hospital. Using the in situ hybridization technique HPV 6/11 was detected in 13.7% and HPV 16/18 in 21.9% among the patients with mild or moderate dysplasia of the cervix. 15% of women in an age-matched control group proved to harbour HPV 6/11 and/or 16/18. In 127 female prostitutes, generally regarded as a high risk group for developing cervical cancer we found in approximately 8% positive HPV-results only. Patients with intraepithelial neoplasias of the cervix or the vulva frequently showed positive virus results in the corresponding organ. There was no significant difference in virus findings among patients with VIN and Bowenoid papulosis of the vulva. 59% of the male partner of 45 patients with positive HPV results from the vagina showed penile lesions in "colposcopy" after exposure to 3% acetic acid. Under the current conditions we regard the proven presence of HPV as an indicator of an increased risk of developing neoplasias of the lower female genital tract.

Cervix Uteri↗