Biomedical subjects

H Furuya

Publications and source records attributed to H Furuya.

At least 307 records · Page 17Linked to original sources

PubMed1981

[Pressures on the human fetus during labor - intrauterine and on the fetal head (author's transl)].

During labor, the body surface of the fetus is subjected to strong pressure exerted by uterine contractions. In 40 cases, intrauterine pressure (IUP) which acts on the fetal body in the uterine cavity and pressure between the presenting part of the fetus and birth canal (PFB) which acts on the part of the fetus engaged in the birth canal were measured to determine the difference in pressure depending on the parts of the fetal body and their changes during the progress of labor. 1) Both peak IUP and PFB values increased gradually in the first stage of labor, and they became double in the period of labor with bearing-down efforts. 2) Since the peak value of PFB was 2.2 to 3.5 times higher than that of IUP, the part of the fetus engaged in the birth canal should always be subjected to 2.2 to 3.5 times more pressure than the intrauterine part of the fetal body. 3) Manual procedures such a vacuum extraction and Krysteller's compression on the uterine fundus increased the peak value of PFB markedly. The objective measurement of the pressure which acts on the fetal head during labor can be considered to contribute to the prevention of cerebral damage and fetal hypoxia.

Female↗

PubMed1980

Evaluation of pericardial effusion with computed tomography.

Evaluation of pericardial effusion was attempted with computed tomography in 11 patients. The volume and distribution of pericardial fluid were assessed with satisfactory resolution and the nature of the fluid was estimated by the difference in x-ray transparency (CT numbers). The volume of pericardial fluid calculated by tomographic methods ranged from 25 ml. to 585 ml. and agreed well with the surgically drained fluid volume. The CT numbers of the pericardial effusion due to renal or heart failure, acute viral pericarditis, hypothyroidism, and hemopericardium were +12 to +13, +20, +28 to +30, and +26 to +40, respectively. Therefore the volume and gross nature of the pericardial fluid could be estimated noninvasively with computed tomography.

Acute Disease↗

PubMed1980

Adult-onset vitamin D-resistant osteomalacia with the unresponsiveness to parathyroid hormone.

Serum immunoreactive parathyroid hormone (PTH) levels were increased in a 50-yr-old man with a unique variant of adult-onset vitamin D-resistant osteomalacia, presenting with high phosphate clearance, mild hypocalcemia, and blunted hypercalcemic and phosphaturic responses to exogenous parathyroid extract. After normalization of his serum calcium level with a large amount of 1 alpha-hydroxycholecalciferol, a synthetic vitamin D analog, serum PTH levels and phosphate clearance returned to normal, and hypercalcemia as well as phosphaturia appeared when parathyroid extract was administered. Further studies demonstrated that the renal response could be restored by the administration of calcium with the suppression of PTH. The evidence presented suggests that the resistance of PTH in this patient was due to secondary hyperparathyroidism rather than to a defect of PTH-sensitive receptors of the kidney and bone or to inadequacy of vitamin D per se.

Calcium↗

PubMed1980

Evaluation of cardiac diseases with computed tomography.

Fifty-six consecutive patients with various cardiac diseases were studied with a third-generation whole body computed tomographic system. Enhancement was performed by intravenous injection of angiographic contrast medium. Identification of the great vessels, atria and ventricles, and evaluation of abnormalities in these structures were possible by cardiac computed tomography. For example, enlarged left ventricle in the left ventricular volume load, enlarged right ventricle in the right ventricular volume load or hypertrophied interventricular septum in idiopathic hypertrophic subaortic stenosis were revealed with a satisfactory resolution. Pericardial effusion and intracardiac thrombi were most precisely assessed by computed cardiac tomography.

Adult↗

PubMed1980

Activities of Ca2+-ATPase and Na+ + K+-ATPase in human placenta.

Although there have been a few reports on Ca2+-ATPase and Na+ + K+-ATPase in human placenta, they are still insufficient for getting more detailed information about human placenta. In this study we investigated some characteristics of the Ca2+-ATPase and measured the activity of Ca2+-ATPase and Na+ + K+-ATPase at various gestational periods. Maximum activity of Ca2+-ATPase was seen at 3 mM and pH 9.0. The enzyme was distinguished from ALP (i.e., Alkaline phosphatase) by such tests as adding L-phenylalanine and heat treatment. Our measurement results of Ca2+-ATPase activity (mumoles Pi/mg protein/30 min) in human placental chorion were 21.9 +/- 2.4 (Mean +/- S.D.) at 10-15 gestational weeks, 19.1 +/- 1.4 at 16-27 gestational weeks, 31.4 +/- 7.2 at 28-35 gestational weeks, and at 36-42 gestational weeks, the AFD group showed 25.8 +/- 4.6, the LFD group, 27.9 +/- 2.1, and the SFD group, 21.2 +/- 1.9. Those of Na+ + K+-ATPase activity (mumoles Pi/mg protein/30 min) were 0.98 +/- 0.05 at 10-15 gestational weeks, 0.82 +/- 0.02 at 16-27 gestational weeks, 1.85 +/- 0.42 at 28-35 gestational weeks and at 36-42 gestational weeks, the AFD group showed 1.58 +/- 0.45, the LFD group, 1.49 +/- 0.37, and the SFD group, 1.68 +/- 0.36. As a result, Ca2+-ATPase activity tended to be higher at 28-35 gestational weeks than for other periods, while it showed lower for the SFD group than for the AFD group. As regards to Na+ + K+-ATPase activity, there were not seen any significant differences between the AFD placenta and the LFD placenta as compared with the AFD placenta.

Alkaline Phosphatase↗

PubMed1980

Clinical application of cardiovascular computed tomography.

The application of computed tomography to cardiovascular diagnosis was attempted. One hundred and four consecutive patients with various cardiovascular diseases were studied with a third-generation computed tomographic three-second whole body scanner. Identification and evaluation of abnormalities of the great vessels, atria, ventricles and interventricular septum were possible by cardiac computed tomography. Sizes and locations of intracardiac thrombi were accurately assessed by computed tomography. Computed tomography was valuable for the evaluation of pericardial effusion because distribution of the effusion as well as the gross nature of the fluid could be estimated by the CT number.

Cardiovascular Diseases↗

PubMed1980

[Clinical observation of serous ferritin levels in obstetrics and gynecology--relation between maternal, fetal and neonatal sera (author's transl)].

a. By the 2-site radioimmunoassay, maternal, umbilical and neonatal sera of human were measured. b. Non-heme iron contents of some organs of maternal, fetal and neonatal mice were analysed and each segment was measured. The results were as follows. 1) The serous ferritin levels of early, mid and late pregnancy were 34.1 +/- 19.0 ng/ml, 22.9 +/- 12.2 ng/ml and 19.4 +/- 11.7 ng/ml respectively in non-anemic group, while 15.1 +/- 7.8 ng/ml, 10.2 +/- 6.7 ng/ml and 5.2 +/- 2.2 ng/ml in anemic group, both decreasing in the course of the pregnancy. 2) The serous ferritin levels of umbilical cords were significantly higher than those of mothers, and no relationship was found between them. According to the maternal serous ferritin levels, grouped into (a) less than 15 ng/ml, (b) over 15 ng/ml and less than 30 ng/ml, (c) more than 20 ng/ml, significant difference of umbilical serous ferritin levels was found between in (a) (b) and in (c). 3) Serous ferritin levels of neonate increased to peak on the 4th to 5th day after birth, as the serous bilirubin levels did. 4) Non-heme iron contents of some organs of pregnant mice varied a great deal, but the SII (containing the ferritin) segment increased in the course of pregnancy and during the puerperium.

Animals↗

PubMed1980

Biodynamics of the cervical dilatation in human labor.

We recorded the pressure between the fetus and birth canal (PFB) with small strain-gauge type pressure transducers in 37 cases of human labor and estimated expulsive activity for evaluation of the expulsive forces. Expulsive activity increased progressively in conjunction with cervical dilatation and markedly increased after rupture of the membranes. At less than 200 Hashimoto units of expulsive activity, the cervical canal could not be dilated and labor was prolonged in all periods of the first stage of labor. There were three types of modes of changes in the expulsive activities at three points on the cervical canal. These three types had different clinical characteristics of cervical dilatation during labor. New parameters such as the expulsive effort, efficiency index and resistance index of the uterine cervix, estimated together with the expulsive activity, were proposed in an attempt to evaluate the effect of expulsive forces on cervical dilatation.

Amnion↗

PubMed1980

Holter system electrocardiographic studies on 617 cases.

Holter system electrocardiograms were recorded for 617 patients who were treated at the Department of Cardiology, Tokai University Hospital. In cases of arrhythmia, ventricular premature contraction (VPC) was the most predominant, in 291 cases (69%) out of 423 with arrhythmia, followed by 59 (14%) with supraventricular premature contraction (SVPC), 23 (5.4%) with paroxysmal atrial tachycardia, 17 (4%) with second degree A-V block and 10 (2.3%) with transient atrial fibrillation (AF). In addition, nine (2.1%) cases of ventricular tachycardia (VT), one (0.2%) of transient ventricular fibrillation (VF) and one (0.2%) of third degree A-V block were found in particularly severe arrhythmia cases. Six out of nine cases of VT were cases of acute myocardial infarction (AMI) and all died suddenly while in the hospital or after discharge. Mild or moderate changes in ST-T were often observed even in normal subjects. Of the 617 cases, only 18 (2.9%) showed a significant elevation or depression of ST. Among these, three definitely had variant angina pectoris (Prinzmetal type). The above results indicate Holter EKGs are very useful for the diagnosis of arrhythmia and can also be used as a means of evaluating the prognosis in some cases, but there still are some problems in connection with its use for the diagnosis of ischemic heart disease except for the diagnosis of variant angina pectoris.

Adolescent↗

PubMed1980

Interruption of pseudopregnancy by rostral periventricular preoptic lesions in the female rat.

Lesions made in the rostral periventricular region of the basal preoptic area (POA) effectively interrupted pseudopregnancy in female rats. However, lesions in the dorsal POA, lateral POA, nucleus and diagonal band of Broca or nucleus accumbens failed to interrupt pseudopregnancy. This suggests that the rostral periventricular POA may play a stimulatory role in regulating prolactin release during pseudopregnancy.

Animals↗

PubMed1979

Chest roentgenograms in primary pulmonary hypertension.

The characteristics of 59 chest roentgenograms of patients with primary pulmonary hypertension were investigated and compared with roentgenograms of 100 healthy control subjects. The relationship with pulmonary hemodynamics was also examined. In primary pulmonary hypertension, there was remarkable protrusion of the main pulmonary artery; the DPA (T/2) and the PL/T index (see text) had high values. These indices depend mainly on pulmonary hypertension, but are partially determined physically by the size of the individual heart. The width of the descending branch of the right pulmonary artery (dPA) was about double the control value (P less than 0.001). The cardiothoracic ratio was significantly increased in primary pulmonary hypertension and there was a positive correlation between the ratio and the mean right atrial pressure (r = 0.37, P less than 0.01). However, there was no correlation with pulmonary arterial pressure or other pulmonary hemodynamic parameters. These results indicate that the increase in the cardiothoracic ratio in primary pulmonary hypertension is caused mainly by right heart failure.

Adolescent↗

PubMed1979