Search PubMed⌕ Search

Biomedical subjects

H Furuya

Publications and source records attributed to H Furuya.

At least 271 records · Page 15Linked to original sources
PubMed1985

[Evaluation of left ventricular function by digital subtraction angiography: effect of dose and administration mode of contrast medium, and comparison with direct ventriculography].

Effects of contrast medium doses on left ventriculographic images using intravenous digital subtraction angiography (IVDSA-LVG) were assessed. The validity of IVDSA-LVG in evaluating ejection fraction (EF) and left ventricular regional wall motion was determined by comparison with conventional left ventriculography using direct injection (direct LVG). The advantages of left ventriculography using intraarterial subtraction angiography (IADSA-LVG) performed by injecting small doses of contrast media directly into the left ventricle were stressed. To assess the effects of doses of contrast media on IVDSA-LVG, 10, 20, and 30 ml Urografin-76 were injected into the superior vena cava in 16 patients, and the resulting images were compared in each patient. With only 10 ml contrast medium, left ventricular opacification was fairly good, and regional wall motion was evaluated in many cases, but 30 ml were needed to calculate ventricular volume and EF. To determine the validity of IVDSA-LVG in evaluating EF and regional wall motion, we compared IVDSA-LVG using 30 ml of contrast medium with direct LVG in 18 patients. There was a good correlation between the two methods in determining EF (r = 0.877), and 90% of the interpretations of regional wall motion were in agreement by the two methods. IVDSA-LVG was useful and accurate in evaluating EF and regional wall motion of the left ventricle. IADSA-LVG was performed for five patients, and good quality images were obtained in many cases, even with relatively small doses (10 ml) of contrast media. These results suggested that this method may be used in cases with impaired LV function, to avoid hemodynamic derangement induced by conventional direct LVG using large doses of contrast medium.

Adult↗
PubMed1985

The changes in CAP activity in first trimester placental chorionic villi and maternal serum, and their clinical significance.

We investigated the CAP activity of placental chorionic villi and maternal serum in the first trimester using a new ultramicro fluorometric method and obtained the following results: The CAP activity of the lysosome fraction (C3) was the greatest of the first trimester villi fractions (6.8 +/- 1.5n mol AMC/min/mg protein). No changes in CAP activity were seen in each fraction for the same wet weights of chorionic villi obtained during the different trimesters. The peak volumes (found with Sephadex G200) of the first trimester chorionic villi C3 fraction and the first trimester maternal serum almost coincided. CAP activity in normal healthy pregnant women in the 5th to 13th weeks of gestation rose gradually as pregnancy advanced. Maternal serum CAP activity was found to be lower than normal when abortion was imminent, but in cases in which the prognosis was favorable, the clinical signs, such as genital bleeding and lower abdominal pain, vanished and the values returned to within the normal range. However, when the prognosis was poor, the clinical signs did not improve and the values remained below normal. These findings suggest that first trimester CAP is produced by the lysosome fraction (C3) of the chorionic villi and that its activity in the maternal serum is directly related to placental function.

Abortion, Threatened↗
PubMed1985

A new data analyzing tocodynamometer and its suitability for clinical application.

Actual intrauterine pressure (IUP) was measured continuously by the extraamniotic method for the monitoring of uterine contractions (UC) throughout the entire course of labor. As a result, it was found by using a PDP 11/60 minicomputer that the wave of intrauterine pressure levels includes signals below a frequency of 0.05 Hz and that a period of 10 minutes is suitable for averaging the levels of parameters of IUP which makes it possible to evaluate the average expulsive activity. A new data analyzing tocodynamometer with a digital low pass filter was developed based on the data mentioned above, and the average values for maximum active pressure, the UC area and UC interval were computed simultaneously. The data for these factors were digitally displayed and printed on recording paper at every UC time. These values were clinically useful for drawing the partograms and were available to use in trying to express the expulsive activity in simple "labor index" terms.

Computers↗
PubMed1984

Haemodynamic effects of nicardipine hydrochloride. Studies during its use to control acute hypertension in anaesthetized patients.

Fourteen patients with vascular disease were studied to evaluate the efficacy of nicardipine hydrochloride as a hypotensive agent in the treatment of acute hypertension occurring during anaesthesia. Five patients received a bolus injection of nicardipine hydrochloride 0.5 mg. Another nine patients received bolus injections of nicardipine 1 and 2 mg. Nicardipine 0.5 mg significantly decreased systemic arterial pressure (by about 24%), systemic vascular resistance (SVR), left ventricular stroke work index (LVSWI) and rate-pressure product (RPP). Nicardipine 1 or 2 mg had twice the effect in decreasing arterial pressure as did 0.5 mg, without significant change in heart rate or right and left ventricular filling pressures. Cardiac index and stroke volume index increased and SVR, pulmonary vascular resistance, LVSWI and RPP decreased significantly.

Acute Disease↗
PubMed1983

Evaluation of intracardiac thrombus with computed tomography.

Left atrial (LA) and left ventricular (LV) thrombus was evaluated by computed tomography in 56 patients. The patients were divided into 2 groups: Group I, 28 patients with mitral valve disease, and Group II, 28 patients with myocardial infarction. Computed tomography and 2-dimensional echocardiography were performed in all the patients studied. Cineangiocardiography was performed in all Group I and in 13 Group II patients. Open heart surgery or autopsy was performed in all Group I and 4 Group II patients. The sensitivity in detecting LA thrombus was 100% with computed tomography, 70% with angiocardiography, and 60% with 2-dimensional echocardiography. The specificity in detecting LA thrombus was 91% with computed tomography, 86% with 2-dimensional echocardiography, and 88% with angiocardiography. Thrombi located at the LA appendage were associated with great difficulties in detection by other methods, but were well delineated with computed tomography. LV thrombus was also visualized by computed tomography with similar or greater accuracy than other diagnostic methods, although the sensitivity and specificity were not ascertained because surgery or autopsy was performed in only a minority of Group II patients. Therefore, as far as the detection of intracardiac thrombus is concerned, computed tomography has the advantage of offering uniform slices of the heart in an attempt to detect thrombi in unknown areas of cardiac chambers, including the LA appendage or LV apex, without being disturbed by the surrounding cardiac and noncardiac structures. Thus, computed tomography has excellent accuracy in the detection of intracardiac thrombus.

Adult↗
PubMed1983

Detection of air embolism by transesophageal echocardiography.

In this study transesophageal echocardiography was utilized for detecting air embolism in dogs in the supine position and in patients undergoing neurosurgery in the sitting position. In dogs, the threshold dose of venous air for detection was determined using either a bolus injection or continuous infusion of air via the jugular vein for up to three minutes. The ability to detect air in the aorta also was determined by a bolus injection into the left ventricular via an arterial catheter. For venous injection of air, the threshold dose by bolus was 0.02 ml/kg. When given by infusion, air could be detected in all cases by both contrast echocardiogram and Doppler sound changes at the rate of 0.05 ml . kg-1 . min-1. When air was injected into the left ventricle, the threshold dose was 0.001 ml/kg using contrast echocardiogram. In the clinical evaluation, air was clearly demonstrated in five of six patients by transesophageal echocardiogram along with appropriate changes in Doppler sounds, pulmonary artery pressure, and end-tidal carbon dioxide concentration. Our results suggest that transesophageal echocardiography may be a more sensitive and accurate method for detecting venous air embolism than other commonly used monitors for patients undergoing neurosurgical procedures in the sitting position. This device may also be able to detect air in the aorta in patients experiencing paradoxical air embolism during surgery due to intracardiac or pulmonary shunts.

Adolescent↗
PubMed1982

Developmental changes of the hypogastric ganglion associated with the differentiation of the reproductive tracts in the mouse.

Prenatal exposure of male or female mice to diethylstilbestrol (DES) or testosterone propionate (TP) from days 9 to 16 of gestation produces pseudohermaphrodites with dual reproductive tracts. In these animals, the hypogastric ganglion which is thought to innervate the internal genitalia was examined at birth. The number of ganglion cells was significantly larger in prenatally DES-exposed male and TP-exposed female mice than that of controls. These results suggest that the number of hypogastric ganglion cells is dependent on the number of the target organs for innervation.

Animals↗