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Biomedical subjects

H Fukushima

Publications and source records attributed to H Fukushima.

At least 361 records · Page 20Linked to original sources
PubMed1981

False aneurysm with subdural hematoma and symptomatic vasospasm following head injury.

A rare case of cortical false aneurysm in a subdural hematoma and symptomatic vasospasm following head injury without skull fracture is reported. Angiography led to the correct preoperative diagnosis and successful surgical treatment, although the patient's symptoms of acalculia, agraphia, and astereognosis, mainly due to the vasospasm of the proximal portion of the middle cerebral artery, remained unchanged. The mechanism of such a cortical false aneurysm and symptomatic vasospasm is discussed briefly.

Adult↗
PubMed1981

A postmortem study of malignant glucagonoma with heart muscle hypertrophy, including chemical, histochemical, immunohistological and ultrastructural observations.

The autopsy findings in a 58 year old female with the typical glucagonoma syndrome with heart muscle hypertrophy are described. Despite remission of a skin rash and hyperglucagonemia following removal of metastatic liver tumors, the patient died of massive cerebral hemorrhage caused by uncontrolled hypertension and septic cerebral angiitis. On the basis of surgical and autopsy materials, the tumors in the pancreas and liver were defined as malignant glucagonoma by histological, histochemical, immunohistochemical, and ultrastructural studies. The pathohistological changes in several organs that might be related to the hypersecretion of pancreatic glucagon are discussed.

Adenoma, Islet Cell↗
PubMed1981

A case with glucagonoma syndrome--endocrine and metabolic studies.

The results of clinical endocrine and metabolic studies on a 57-year-old female with surgically and autopsy verified glucagonoma syndrome were presented. All of the clinical manifestations of glucagonoma syndrome so far reported in the literature were noted but there was no evidence indicating the presence of multiple endocrine adenomatosis. The plasma IRG level was always more than 20 times above the normal, and the IRG response to insulin and tolbutamide injection was abnormal and the results of the other endocrinological studies revealed less remarkable features, if any. The surgically removed metastatic tumor of the liver contained an enormous amount of IRG and an appreciable amount of IRI, indicating that the elevated plasma IRG was mainly of tumor origin. These results clearly indicate that in glucagonoma there is some abnormality in glucagon release from the tumor. In addition to these findings, hypocalcemia, cardiac left ventricular hypertrophy and gastrointestinal dysfunction reportedly due to hyperglucagonemia were also seen in this patient.

Adenoma, Islet Cell↗
PubMed1981

A case with glucagonoma syndrome--heterogeneity of glucagon and insulin.

The heterogeneity of glucagon and insulin in plasma and tissue extracts from a 57-year-old female with glucagonoma syndrome with surgically and autopsy verified islet-cell tumors was studied by Bio-Gel P-10 filtration. The preoperative plasma immunoreactive glucagon (IRG) level was 20.2 ng/ml, and plasma glucagon-like immunoreactivity(GLI) 25.8 ng/ml. The column chromatography of the preoperative plasma revealed three or four IRG components and four GLI components. Among these, peak II, the large glucagon immunoreactivity (LGI) peak, considered a candidate for proglucagon, was prominent, along with peak III. The resected metastatic liver tumor contained an enormous amount of IRG and an appreciable amount of immunoreactive insulin (IRI), indicating that the elevated plasma IRG was mainly of tumor origin. The IRG pattern of the tumor tissue extract revealed a small quantity of IRG in peaks I and II, and a large amount in peak III; control pancreatic tissue extract manifested a similar elution pattern. The IRI elution pattern of the tumor tissue extract revealed two major IRI peaks which migrated close to the elution volume of cytochrome C and insulin, respectively. This is a quite different pattern from the control pancreatic tissue extract in which the RI peak was localized in the elution volume of the insulin. We conclude that the present metastatic liver tumor produced not only enormous amounts of glucagon but heterogeneous peptides which contained immunological insulin determinants within their.

Adenoma, Islet Cell↗
PubMed1981

Immune response of man to Habu-venom toxoid.

Immune response of man to various Habu-venom toxoids with different potencies was investigated. A linear relationship was observed between circulating anti-HRI and the amount of HRI toxoid used for the basic immunization. A highly purified toxoid was 2.5 times more effective in man than partially purified ones, when compared on the basis of the immunizing unit determined in guinea pigs. Out of 265 vaccinees, 202 (76.2%) produced anti-HRI exceeding 1 U/ml after two injections of the mixed toxoid and the rate rose to 96% after the booster immunization, when the preparation contained HR1 toxoid of not less than 9 ImU per dose. The rate fell to 58% and 28.5%, 12 months and 24 months after the last injection, respectively. Although booster immunization was effective to restore the declined antibody production, the level of anti-HR1 after the injection did not exceed that after the basic immunization in the groups primed with partially purified HR1 toxoid. Neither increased number of injection nor changed duration of intervals of successive injections for the basic immunization improved the immune response of man. Booster effect was slightly higher in the groups primed with a highly purified toxoid, but its magnitude was much smaller than that in the case of other kinds of toxoid (e.g. tetanus toxoid). Anti-HR2 was invariably higher than 1 U/ml, being more than 5-10 U/ml in many vaccinees. However, the behavior after the booster injection was similar to that of anti-HR1. Side reaction was not a serious obstacle in continuing immunization. The volunteers amounted to 8,206, but general reactions were rare, if any. However, allergic reactions of the vaccinees should carefully be checked, since repeated booster immunization may be necessary to maintain immunity.

Antibody Formation↗
PubMed1980

Studies on thermal adaptation in Tetrahymena membrane lipids. Positional distribution of fatty acid in diacyl- and alkyl-acyl-phosphatidylcholines and -(2-aminoethyl)phosphonolipids from cells grown at different temperatures.

Phosphatidylcholine and 2-aminoethylphosphonolipid, major membrane phospholipids in Tetrahymena, comprise 1,2-diacyl and 1-alkyl-2-acyl moieties, whereas phosphatidylethanolamine is solely in diacyl form. The overall fatty acid composition of phosphatidylcholine and 2-aminoethylphosphonolipid fractions from 15 degrees C-grown cells mainly consisted of linoleic (C18 : 2 delta 9,12) and gamma-linolenic (C18 : 3 delta 6,9,12) acids, except for the large amount of an usual fatty acid, cilienic acid (C18 : 2 delta 6,11) in 2-aminoethylphosphonolipids. When compared with 39.5 degrees C-grown cells, the 1-position of phosphatidylcholine and 2-aminoethylphosphonolipid from 15 degrees C-grown cells undergoes a large increase in palmitoleic (C16 : 1 delta 9) and gamma-linolenic acids with a corresponding decrease of myristic (C14 : 0) and palmitic (C16 : 0) acids. At the 2-position of 15 degrees C-grown cells, linoleic and gamma-linolenic acids in phosphatidylcholine, and cilienic and linoleic acids in 2-aminoethylphosphonolipid increase with a large decrease of palmitoleic acid in both phospholipids and of gamma-linolenic acid in 2-aminoethylphosphonolipid. There was quite a similarity in fatty acid composition between 1,2-diacylphosphatidylcholine and 1,2-diacyl-(2-aminoethyl)phosphonolipid in 39.5 degrees C- and 15 degrees C-grown cells. However, a marked increase of gamma-linolenic acid at the 1-position of 1,2-diacyl-phosphatidylcholine, and of linoleic acid at the 2-position of diacyl-aminoethylphosphonolipid was observed in 15 degrees C-grown cells. The 2-position of 1-alkyl-2-acyl-phosphatidylcholine and 1-alkyl-2-acyl-(2-aminoethyl)phosphonolipid was occupied mainly by unsaturated fatty acids. In 15 degrees C-grown cells, the sum of linoleic and gamma-linolenic acids accounted for 79.9% in 1-alkyl-2-acyl-phosphatidylcholine and 87.1% in 1-alkyl-2-acyl-(2-aminoethyl)phosphonolipid. These data support the hypothesis that 2-aminoethylphosphonolipid and phosphatidylcholine would play an important role as acceptors of polyunsaturated fatty acids (C18 : 2 delta 6,11, C18 : 2 delta 9,12 and C18: 3 delta 6,9,12) for temperature acclimation. Furthermore, changes in the ratio of diacyl- to alkyl-acylphosphatidylcholine may also be involved in thermal adaptation by regulating the number of fatty acid acceptor.

Animals↗
PubMed1980

[A case of thyroid storm associated with diabetic ketoacidosis (author's transl)].

A 31-year-old female was well until few years ago when she was diagnosed as having Graves' disease. Methimazole (MMI) and Lugol's solution were prescribed. But 7 months later, she stopped taking them arbitrarily. Three months later, thirst and general fatigue appeared. Therefore insulin (60u/day) and MMI (30 mg/day) were administered and continued for 40 days. However no remarkable effect was brought about. She was then transferred to the radioisotope ward of Kumamoto Univ. Hospital and was treated with regular insulin only. Ten days later, she fell into thyroid storm associated with diabetic ketoacidosis and was transferred to our ward. We began to administer large volumes of transfusion, regular insulin, MMI, Lugol's solution, propranolol, hydrocortisone and digitalis. In 24 hours, ketoacidosis disappeared and she became alert. For hyperthyroidism, the dosage of MMI was increased to 60 approximately 45 mg/day and was continued for a month; however, her thyroid function did not normalize and agranulocytosis developed. MMI was discontinued, and she was treated with 131I. About a year later, she became euthyroid. Her diabetes mellitus was difficult to control during the hyperthyroid state but it was under good control with monocomponent lente insulin (36u/day) when the euthyroid state was resumed.

Adult↗
PubMed1980

Synthesis and immunological activity of 5,6,6a,8,9,11a-hexahydronaphth[1',2':4,5]imidazo[2,1-b]thiazoles and 5,6,6a,9,10,11a-hexahydroanaphth[2',1':4,5]imidazo[2,1-b]thiazoles.

A series of 5,6,6a,8,9,11a-hexahydroanaphth[1',2':4,5]imidazo[2,q-b]thiazoles (17 and 20) and 5,6,6a,9,10,11a-hexahydronaphth[2',1':4,5]imidazo[2,1-b]thiazoles has been synthesized with cis- and/or trans-1,2-diamino-1,2,3,4-tetrahydronaphthalenes as the key intermediates and subsequently evaluated for immunological activity (effects on antibody formation and delayed-type hypersensitivity reaction). Among the compounds tested trans-5,6,6a,8,9,11a-hexahydronaphth[1',2':4,5]imidazo[2,1-b]thiazole (trans-17a) and (+/-)-5,6,6a beta,8,9,11a alpha-hexahydro-8 beta-hydroxy-9 beta-methyl-8 alpha-phenylnaphth[1',2':4,5]imidazo[2,1-b]thiazole (20a) showed the largest immunological activity in mice with a magnitude comparable to that of levamisole and were found to be considerably less toxic than levamisole in acute toxicological study. The structures of 18a and 20a were determined by X-ray crystallography.

Adjuvants, Immunologic↗