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Biomedical subjects

H Fukui

Publications and source records attributed to H Fukui.

At least 541 records · Page 30Linked to original sources
PubMed1979

A case of hypogonadotropic eunuchoidism associated with familiar periodic paralysis--induction of paralytic attacks by testosterone administration.

A case report was made of a 24-year-old man suffering from hypogonadotropic eunuchoidism associated with a hypokalemic type of familiar periodic paralysis. The attacks were observed only during the period of continual administration of the oil solution of 115.7 mg of testosterone enanthate and 20.0 mg of testosterone propionate, intramuscularly as a depot. From the findings on this patient, it was concluded that testosterone might possibly play a role in the occurrence of attacks in the case of periodic paralysis.

Adult↗
PubMed1978

Coronary vasospastic action of thromboxane A2 in isolated, working guinea pig hearts.

The effects of thromboxane A2 (TXA2) on isolated, working guinea pig heart and left ventricular papillary muscle preparations were investigated. TXA2 was generated by the enzymatic conversion of prostaglandin H2 (PGH2) with indomethacin-treated horse platelet microsomes (IPM). TXA2 caused dose-dependently a considerable decrease in the coronary flow, left ventricular systolic pressure and left ventricular dp/dt in the perfused heart, while the similar effects of PGH2 were transient and weaker than those of TXA2. These effects of TXA2 disappeared after the TXA2-generating system was left standing at 37 degree C for 3 min. When IPM in the TXA2-generating system was pretreated with a TXA2 synthetase inhibitor, L-8027, the enhanced cardiac responses induced by the mixture of IPM and PGH2 disappeared. TXA2 had no direct effect on the contractile force of the papillary muscle. These results suggest that TXA2 has a specific coronary vasopastic action without a direct inotropic effect.

Animals↗
PubMed1977

Studies of von Willebrand factor: effects of different kinds of carbohydrate oxidases, SH-inhibitors and some other chemical reagents.

The effects of several kinds of carbohydrate oxidase, SH-inhibitors and some other chemical reagents on the activities of von Willebrand factor, factor VIII procoagulant and factor VIII-related antigen were studied. Factor VIII procoagulant and von Willebrand factor activities were both inhibited by galactose oxidase, p-hydroxymercuribenzoic acid, 2,4,6-trinitrobenzensulfonic acid and sodium periodate, alpha-Mannosidase, N-ethylmaleimide and phospholipase C inactivated factor VIII procoagulant but not von Willebrand factor activity. Dithiothreitol had little effect on factor VIII procoagulant activity but reduced significantly that of von Willebrand factor. It is suggested that galactose and the thiol and epsilon-aminogroup groups of lysine may play an important role in both factor VIII procoagulant and von Willebrand factor activity. Mannose may be responsible for the factor VIII procoagulant activity but not for the von Willebrand factor activity. The Laurell rocket heights of factor VIII-related antigen rose with increasing concentration of galactose oxidase, 2,4,6-trinitrobenzenesulfonic acid or sodium periodate. Gel filtration experiments showed that factor VIII-related antigen may be dissociated into subunits by galactose oxidase but not by 2,4,6-trinitrobenzenesulfonic acid or sodium periodate.

Antigens↗
PubMed1977

[Studies of calcium phosphate glass-ceramics--development of dental materials. (Part 2) Acid resistance--(author's transl)].

It is well known that minerals of bone or tooth are essentially of CaO-P2O5 system. Glass and the crystallized product, i.e., so-called "glass-ceramics" of which chemical composition is 55 CaO . 45 P2O5 (in mole %) and have been developed for biomaterials were subjected to chemical durability test. Human enamel was also tested for the comparison of the data with them. All the specimens were ground to powders in size from 74 to 140 micrometer. A hundred milligram of the powders were immersed into 100 ml. of N/10 acetate buffer (1 mol acetic acid) solution (pH 4.1) at a constant temperature of 37 degrees C. Amount of Ca2+ and P5+ dissolved were determined by an atomic absorption method and Fiske-Subbarow method, respectively. The order of dissolution is human enamel greater than glass greater than glass-ceramics: the amount of Ca2+ (SCa) and P5+ (Sp) with soaking time (t) was expressed by the following equations, :formula: (see book). The glass and the glass-ceramics show good resistance against a weak acid.

Acids↗