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Biomedical subjects

H Fujino

Publications and source records attributed to H Fujino.

At least 127 records · Page 7Linked to original sources
PubMed1983

Effects of thyrotropin-releasing hormone on catecholamine concentration in various structures of the rat brain.

In an attempt to identify the site of TRH-action in the central nervous system (CNS), we have measured catecholamine levels in discrete brain regions of rats after an intravenous administration of TRH or a long-term intraventricular administration of TRH using Alzet's osmotic minipump. An intravenous administration of 50 micrograms TRH caused a rapid increase in dopamine (DA) concentration in the septal nucleus and then returned to the basal level at 30 min after injection. The concentration of DA in the septal nucleus after the long-term TRH intraventricular administration was also significantly higher than that in the controls. These results indicate that a long-term intraventricular administration of TRH as well as a bolus intravenous injection of TRH may affect the release or metabolism of DA in the septal nucleus.

Animals↗
PubMed1982

A cerebellar ataxic rat produced by kainic acid and changes in concentration and turnover rates of catecholamines in discrete brain regions.

We made an animal model of cerebellar ataxia by injections of kainic acid into the cerebellar hemispheres on both sides of male rats. The histological and behavioral changes were observed at 4 weeks following the injections. The concentrations of catecholamines and the disappearance rates of alpha-MPT-induced catecholamines were measured in discrete regions of the brain of sham-operated and kainic acid-lesioned rats. A lowered dopamine disappearance rate was seen in the accumbens nucleus of the lesioned rats, but no change in norepinephrine. These findings suggest that the decrease in dopamine turnover in the accumbens nucleus is involved in the development of ataxic behavior.

Animals↗
PubMed1981

[A case of primary cerebral rhabdomyosarcoma (author's transl)].

A primary cerebral rhabdomyosarcoma is reported in a 51-year-old female. She noticed progressive weakness of the left leg in September 1977 and underwent craniotomy for a brain tumor in Tokyo Metropolitan Okubo General Hospital. At the operation the tumor was located on the medial aspect of the right frontal lobe, being attached to the falx. The tumor was 6.0 x 5.0 x 4.0cm in size and subtotally removed. Shortly after operation, she developed a left-sided hemiplegia and was referred to our Kanagawa Rehabilitation Center. During rehabilitation she developed disturbance in recent memory, orientation and speaking. A second operation was done in June 1978, revealing obvious recurrence. A well demarcated extramedullary gray and soft tumor, 7.0 x 5.0 x 3.5cm in size, was found in the previously operated site, being attached to the falx. It was subtotally again. Following surgery her clinical condition was temporally improved. Four months following surgery, however, she developed signs of increased intracranial pressure and died in October 1978 in spite of having chemotherapy and irradiation. Autopsy was not permitted. The tumor was diagnosed as rhabdomyosarcoma with light and electron microscopies and several investigation revealed no primary lesion in elswhere except for the cranium. The histological documentation is also presented and discussed.

Brain Neoplasms↗
PubMed1979

Primary rhabdomyosarcoma of the cerebrum. An ultrastructural study.

A case of primary cerebral rhabdomyosarcoma in a 51-year-old female is reported. The histogenesis of this tumor is discussed. The clinicopathological features of 10 previously reported similar tumors of the CNS are briefly reviewed. Histologically the tumor was polymorphic, but composed of poorly differentiated cells interpreted as rhabdomyoblasts without definite cross-striation. Electron microscopy established that the poorly differentiated cells were of rhabdomyosarcomatous nature, compatible with presumptive myoblasts and analogous to developing fetal muscle.

Brain Neoplasms↗