Search PubMed⌕ Search

Biomedical subjects

H Fujii

Publications and source records attributed to H Fujii.

At least 1,135 records · Page 63Linked to original sources
PubMed1983

[Late results of coronary heart surgery. Late graft patency in coronary bypass procedure].

The graft patency was evaluated by a contrast enhanced computed tomography (CT) and/or digital subtraction angiography (DSA) in the follow up of aorto-coronary bypass surgery. One hundred and eighty-four patients included in this study received a total of 331 grafts. The Elipse S/200 Scanner for CT and Siemens Angiotron system for DSA were used for this study. Early in the study, selective coronary angiography were performed and the results were interpreted in 331 grafts and 86 grafts to evaluate the diagnostic reliability of CT and DSA for graft patency, respectively. While the CT scans correlated with angiographic assessment of graft patency showed 98% of sensitivity, 100% of specificity, and 98% of predicted accuracy, the DSA showed 95% of sensitivity, 100% of specificity and 95% of predicted accuracy, respectively. The patency rate in the early postoperative period was 94%, and the cumulative patency rate during follow up of 5 years was 93%, respectively. In summary, CT and DSA can provide useful information regarding graft patency in the long term follow up of aorto-coronary bypass surgery.

Adult↗
PubMed1983

Estrogen receptor in the "non-lymphocytes" in the thymus of the ovariectomized rat.

Estrogen binding components have been characterized in cytosols from lymphocyte fractions and non-lymphocyte fractions of the thymus and mesenteric lymph node of ovariectomized rats. The cytosol from the non-lymphocyte fraction of the thymus contained high affinity-specific binding estrogen receptor (equilibrium dissociation constant .=. 3 X 10(-10) M, number of binding sites .=. 10 fmol/mg protein) with a sedimentation coefficient of 8 S. The receptor showed specific binding for estradiol-17 beta, estrone and estriol, but not for corticosterone, progesterone or testosterone. Only lower estrogen binding was observed in the cytosols from the lymphocyte fraction of both tissues and the non-lymphocyte fraction of the lymph node. Morphological changes of the thymus in ovariectomized rats after administration of estradiol benzoate were also observed. Clustered vacuoles with incomplete microvilli in the epithelial cells increased in number and in size after estrogen treatment. These findings suggest that the effect of estrogen on the thymus is mediated via the cytoplasmic estrogen receptor in the non-lymphocytes, probably thymic epithelial cells.

Animals↗
PubMed1983

Craniopharyngioma--analysis of surgical procedure.

Twenty cases of craniopharyngiomas treated surgically between 1972 and 1979 have been studed neuro-ophthalmologically. The visual fields demonstrated asymetrical bitemporal hemianopsia, occasionally homonymous hemianopsia and central scotomas. The visual function was followed up for a period of one to 8 years after the operation. Improvement and retention of the visual function were observed in 88% of cases with subtotal resection and irradiation, 45% of cases with partial resection and irradiation, and 0% of totally resected cases. Histopathologically, the dense adhesion and tumor invasion in the optic chiasm were observed in autopsy cases. From the viewpoint of operative results and autopsy findings, the subtotal excision with irradiation is advocated for the treatment of craniopharyngiomas, particularly in the adult cases.

Adolescent↗
PubMed1983

Effect of ovarian steroids on uptake of radioactive amino acids by brain tissues.

Effects of two major ovarian hormones, estrogen (E) and progesterone (P), on the uptake of amino acids by the brain nuclei of ovariectomized mice were examined. They were divided into four groups: (1) oil controls, (2) P-treated, (3) estradiol benzoate (E2B)-treated, and (4) E2B-primed P-treated mice. Two hr after the last hormonal treatment they were given a single s.c. injection of a mixture of 3H-leucine and 3H-methionine, and then sacrificed 2 hr later. Intensity of the uptake of radioactivity was measured on autoradiograms of the stained tissue sections. Group 1 showed a relatively high uptake of radioactivity by the SO, PV and SPH, compared with that by the remaining brain cells. Group 2 had a slight enhancement of the uptake by the VM, SPH and CC, compared with that in group 1. Group 3 showed a significant enhancement of the uptake by most of the preoptico-hypothalamic nuclei except for the VM, DM and PM, compared with that in group 1. Group 4 had slightly enhanced uptake by the POM, POL, SCH, SO, PV, VM, ARC, SPH and CC, compared with that in group 1. E-priming affected the uptake; it enhanced the uptake by the VM and SPH, and inhibited it by the PVA, AH, LH and CC. Uptake by the PM and EC remained unchanged in all groups. The present results suggest that two major steroids, E and P, influence protein synthesis in most of the brain regions including the preoptic and hypothalamic areas.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acids↗
PubMed1983

Progestin receptors in ovaries of 4-day cycling rats. An autoradiographic study.

Using an autoradiographic technique we investigated in vitro the localization of cell constituents with concentrations of a radioactive synthetic progestin (P), 3H-R5020 (17 alpha, 21-dimethyl-19-nor-pregna-4, 9-diene-3, 20-dione) and its metabolites in the ovaries of 4-day cycling adult rats. After incubation of the ovarian tissue sections with radioactive R5020 in the presence or absence of various non-radioactive steroids, specific labeling was found in the tissue sections in each phase of the estrous cycle. The intensity of labeling in the ovary during the estrous cycle was highest in proestrus, followed by that in diestrus, metestrus and estrus. The intensity of labeling in cell constituents was as follows: granulosa cells greater than luteal cells greater than thecal cells greater than stromal cells. These results indicate that the rat ovaries contain cell constituents that specifically bind P and that the intensity of binding fluctuates during the estrous cycle.

Affinity Labels↗
PubMed1983

[A case of solitary myeloma (BJ-lambda) showing marked morphological changes].

The case report here was documented clinically, cytologically and histologically over a period of 5 years. A 49-year-old man was admitted to our hospital in September, 1975 because of a painful lump over the sternum and a diagnosis of solitary well-differentiated plasmocytoma (BJ-lambda) was made. The tumor promptly subsided following chemotherapy. In July, 1980 as it had in June, 1979, the sternal tumor relapsed; morphologically it was a poorly differentiated plasmocytoma. It promptly subsided following the start of chemotherapy and/or radiation therapy. In February, 1981, an abdominal tumor and ascites developed, morphologically it was plasma cell sarcoma composed of giant and bizarre tumor cells of plasma cell origin as demonstrated by immunoelectron microscopy. In April, 1981, the patient died of cachexia. At autopsy, multiple tumor formations consisting of giant and bizarre myeloma cells were found in the abdominal cavity, liver, retroperitoneum, diaphragm, left adrenal gland, mediastinum and lymph nodes. There was no infiltration of myeloma cells into bones other than the sternum.

Abdominal Neoplasms↗