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Biomedical subjects

H Fox

Publications and source records attributed to H Fox.

At least 235 records · Page 13Linked to original sources
PubMed1972

An immunofluorescent study of the distribution of immunoglobulin-containing cells in the normal and the inflamed human gall bladder.

Immunoglobulin-containing cells are present in the normal human gall bladder but they are much less numerous in this site than in the normal intestine. IgA-containing cells predominate in the mucosa but in the muscle layer IgM cells are the more numerous. In both acute and chronic inflammation of the gall bladder there is a marked increase in the number of immunoglobulin-containing cells. In all but the most severe cases of inflammation it is those cells containing IgA which show the greatest increase in numbers, but in severe cases there is a disproportionate rise in the number of IgG- and IgM-containing cells, these latter being possibly derived from the blood. IgA cannot be demonstrated in the epithelial cells of the gall bladder and positive evidence of secretion into the bile of locally produced immunoglobulin is lacking. It is suggested that the concentration of IgA normally present in bile is such that, irrespective of local production, some is derived from the serum or the intestine.

Acute Disease↗
PubMed1972

A histological analysis of granulomatous hepatitis.

A study has been made of 33 cases of granulomatous hepatitis. Of these, 12 were eventually established as cases of sarcoidosis, nine as cases of tuberculosis, and four as examples of primary biliary cirrhosis. No clinical diagnosis was ever reached in six cases. Analysis of the histological features of these cases shows that the presence of caseation or of tubercle bacilli will only allow for the diagnosis of approximately 50% of cases of tuberculosis. Histological features which are suggestive of tuberculosis are a paucity of granulomata, a scantiness of giant cells, a relatively mild surrounding chronic inflammatory cell infiltrate, and an absence of reticulin. The granulomata are more likely to be due to sarcoidosis if they are numerous, contain many giant cells, are confined to the portal areas, and show a well marked surrounding non-specific chronic inflammatory cell infiltrate. Histological features of cases in which no clinical diagnosis was reached suggest that they are more likely to be due to sarcoidosis than to tuberculosis.

Diagnosis, Differential↗