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Biomedical subjects

H Fischer

Publications and source records attributed to H Fischer.

At least 559 records · Page 31Linked to original sources
PubMed1976

[Case of encephalitis in pregnancy].

The author reports a maternal letal case of Encephalitis in pregnancy. The first symptoms stepped calculate termin of birth. A resembling case in the publications up to this day is not described.

Adult↗
PubMed1975

[Cerebral ischemia or post traumatic thrombosis of the A. carotis occuring to a car driver (author's transl)].

A short while after leaving a public-house a 71 year old man as the driver of his car was involved in a head-on collision with another car. On admission to a hospital he was unconscious with a distinct debility for the left side of his body and showed a changing anisocoria. Angiography of the right carotid artery revealed an occlusion. It was suspected that this was the terminal state of a generalized arteriosclerotic occlusion which was considered being the reason for the accident. The autopsy-findings showed, however, a posttraumatic thrombosis (whiplash-trauma of the cervical vertebral column) of the right arteria carotis and of the right arteria vertebralis with thromboembolia in a small pontine artery with an infarct-like ischemic softening. The differentiation from an apoplexia is of importance for the differential diagnosis.

Accidents, Traffic↗
PubMed1975

Simian virus 40-related antigens in three human meningiomas with defined chromosome loss.

Two out of seven meningiomas tested in early cell cultures by indirect immunofluorescence staining showed simian virus 40 (SV40)-related tumor (T) antigen. In one tumor 90% of the cells were positive. An additional SV40-related antigen (U) was found in 10% of cells of a third tumor. These findings indicate that the meningioma cells showing a positive reaction are transformed by a papova virus that has at least partly the same antigenic properties as SV40 virus. SV40-related viral capsid (V) antigen was absent in all the meningiomas tested. No virus infectious for African green monkey kidney (AGMK) cells could be isolated. The tumors positive for T and U antigens showed the chromosome aberration typical for human meningiomas, i.e., the loss of one chromosome, G-22. The T-antigen-positive tumors showed further hypodiploidization. Experiments to rescue virus from the T-antigen-positive tumors showed further hypodiploidization. Experiments to rescue virus from the T-antigen-positive meningioma cells were performed: fusion of cells pretreated with 8-azaguanine with cells premissive for SV40 led to a low percentage (0.01-0.05%) of V-antigen-positive nuclei in heterokaryon cultures. On the basis of these results, the possibility of a correlation between the meningioma, a relatively common intracranial tumor in man, and an SV40-related papova virus must be considered. It remains to be shown whether this virus is a causative agent for human meningiomas.

Adult↗
PubMed1975

Simian virus tumor antigen: a virus-specific and preexisting cell protein.

The tumor (T) antigen of simian virus 40 (SV40)-transformed SV3T3 cells was immune precipitated with T antiserum obtained from hamsters bearing SV40-induced tumors and with rabbit antiserum to hamster cells. The resulting antigen-double antibody complexes were analyzed by sodium dodecyl sulfate polyacrylamide gel electrophoresis. Host components of SV40 T antigen with molecular weights of 70,000 and 30,000 were detected.

Antigen-Antibody Complex↗
PubMed1975

Studies on the mechanism of macrophage-mediated cytotoxicity.

MCF is a product of sensitized T lymphocytes, which is actively synthesized and secreted when lymphocytes are incubated with the appropriate target cells. The process of macrophage activation leading to cytotoxicity needs a period of 24h. Macrophage-mediated cytotoxicity is restricted to the specific target cell. B cell antibody does not seem to be involved. The reaction cannot be inhibited by rabbit antimouse immunoglobulin. However, various conditions, which may interfere with this specificity, are discussed.

Absorption↗