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H Feist

Publications and source records attributed to H Feist.

At least 37 records · Page 2Linked to original sources
PubMed1992

Syntheses of branched-chain sugars with push-pull functionality.

The reaction of methyl 4,6-O-benzylidene-3(2)-deoxy-alpha-D-erythro- hexopyranosid-2(3)-ulose with carbon disulfide, alkyl iodide, and sodium hydride gave methyl 4,6-O-benzylidene-3(2)-[bis(alkylthio)methylene]-3(2)-deoxy-alpha-D- erythro-hexopyranosid-2(3)-uloses. Methyl 4,6-O-benzylidene-2-[bis(methylthio)-methylene]-2-deoxy-alpha-D- erythro-hexopyranosid-3-ulose (5) reacted with aromatic amines to give, in a rearrangement process, N-aryl-2-aryliminomethyl-4,6-O-benzylidene-2-deoxy- alpha-D-erythro-hex-1-enopy-ranosylamin-3-uloses. The reaction of 5 with hydrazine hydrate afforded 5-methylthio-(methyl 4,6-O-benzylidene-2,3-dideoxy-alpha-D-erythro-hexopyranosido)[3,2- c]pyrazole.

Carbohydrate Conformation↗
PubMed1992

[Peptide inhibitors of the renin-angiotensin system. 2. Polymer-bound tri-, penta- and nonapeptide inhibitors of angiotensin converting enzyme].

Inhibitors of the angiotensin converting enzyme (ACE, EC 3.4.15.1) are important in the treatment of the high blood pressure. The therapeutically used drugs captopril, enalapril and ramipril are enzymatic stable short pseudo-peptides. They are stabilized against enzymatic degradation and therefore usefully for oral application. But for some indications e.g. post operative treatment and shock therapy well dosed infusions are needed. For this purpose we attached nona-, penta- and tripeptide inhibitors of the ACE to immunologically inert dextran polymers. The inhibitors are derived as well from the bradykinin potentiating nonapeptide BPP9 alpha (Pyr-Trp-Pro-Arg-Pro-Gln-Ile-Pro-Pro) and the bradykinin potentiating pentapeptide BPP5 alpha (Pyr-Lys-Trp-Ala-Pro), both originally isolated from snake venoms, as from acylated tripeptides with the structure Acyl-AA1-Arg-Pro. We estimated the influence on the biological activity of two different linkers to the dextran polymers. The coupling to the polymer was achieved on the one hand via the aldehyd moiety (DAD-AK) and on the other hand by the carboxyl residue (KMD). In the case of DAD-AK-polymers the condensation of the peptides was performed by the N-hydroxysuccinimide ester of the polymer. Because of the instability of the KMD-OSU in this case water soluble carbodiimides are used. The polymer bound peptides inhibit the isolated ACE, but in the most cases with a reduced activity. Only the tripeptide DPhe-Arg-Pro has a enhanced activity in the polymer bound state. The polymer bound inhibitors show a prolongated action on normotensive rats by intravenous application.(ABSTRACT TRUNCATED AT 250 WORDS)

Amino Acid Sequence↗
PubMed1992

[Results of experimental immunization of calves with different Pasteurella antigens].

Calves immunised with different Pasteurella antigens (inactivated whole cells, sodium chloride extract) where challenged two weeks after the second immunization with the homologous strain. The intracutaneous application of whole cells of P. haemolytica A1 and P. multocida A was effective. The incidence of pneumonia was reduced and the pneumonic lesions were less severe. The sodium chloride extract was not effective.

Animals↗
PubMed1991

Sequential therapy with i.v. and oral ofloxacin in lower respiratory tract infections: a comparative study.

The results of an open randomised trial comparing the efficacy of parenteral and oral ofloxacin with that of amoxycillin clavulanate are reported. Of 121 patients enrolled, 92 were clinically evaluable, of whom 59 were treated with ofloxacin and 33 with amoxycillin clavulanate. In the ofloxacin group all patients improved clinically, while in the amoxycillin clavulanate group 94% improved and 6% were clinical failures. In the ofloxacin group 95% showed satisfactory bacteriological response, while in the amoxicillin clavulanate group the bacteriological response was judged satisfactory in 82% of the patients. Seven percent of the patients had mild side effects (headache, nausea, vomiting and skin rashes). All of these side effects disappeared after treatment. We conclude that ofloxacin is a safe and effective drug in oral and parenteral forms for the treatment of lower respiratory tract infections.

Administration, Oral↗
PubMed1988

[Influence of regenerating and evaluation procedures on the supralinear behavior of LiF thermoluminescent dosimeters].

Measurements with LiF dosimeters in the absorbed dose range up to 6 Gy have shown a strong influence of the annealing and reading procedure on inset and extent of the supralinearity. With this regard three TLD readers and two annealing procedures have been investigated. The results are explained by a theoretical model which takes the formation of vacancies by hydroxyl ions into account. A slight effect of the LET is also observed. Since a straight line fit to the measured dose dependent deviations from linearity is possible, a quadratic equation for the calculation of correct absorbed dose values could be derived.

Fluorides↗
PubMed1987

[Comparison of the effectiveness of ceftazidime and cefazolin/tobramycin in patients with inflammatory diseases of the lower respiratory tract].

We compared the efficacy of ceftazidime and cefazolin in combination with tobramycin in the treatment of lower respiratory tract infections. Bacterial pathogens were isolated from sputum or bronchial secretions from 92 patients. The clinical results were identical in both groups: All patients showed an improvement of the clinical symptoms or were cured. 88% of the patients in the ceftazidime-group and 76% of the patients in the cefazolin/tobramycin-group showed an eradication of the pathogens without superinfection. This difference was not statistically significant (p = 0.095). Monotherapy with ceftazidime was clinically and bacteriologically as effective as a combination therapy with cefazolin and tobramycin.

Adult↗
PubMed1986

[The heptose region of lipopolysaccharides of Pasteurella multocida].

The heptose region of the lipopolysaccharides (LPS) of Pasteurella multocida consists of the trisaccharide L Hep 1----2 L Hep 1----3 L Hep or L Hep 1----3 L Hep 1----2 L Hep. This trisaccharide and the oligosaccharide consisting of 3 moles heptose and 1 mole glucose were isolated from the LPS of the strain D 33. The data suggest that the LPS biosynthesis of P. multocida is different from that of Salmonella spp.

Chemical Phenomena↗
PubMed1986

The effects of almitrine at rest and on exercise in COPD patients.

Almitrine has significantly improved blood gases in patients with COPD without changing the pulmonary function either at rest or on exercise. Proceeding from these preliminary results we are about to start a long term study in our country. In the course of this we hope to clear up various problems, first of all the distinction between responders and non-responders should be made in order to clarify the indications for almitrine. If it would be possible to prove this effect in long term therapy, the benefits for the patients must be the same as for long term oxygen therapy.

Aged↗
PubMed1986

[Radiotherapy of seminoma: small-volume irradiation at the stage pT1N0M0--prophylactic irradiation of the mediastinum].

122 patients suffering from seminoma were irradiated between 1971 and 1981 at the Radiotherapy Department of the University of Munich. 113 patients were available for retrospective analysis. The ten year actuarial survival for all patients was 93%. The survival rate in stage pT1N0M0 (UICC classification) was 100%, in stage pT2-4-xN0M0 97%, in stage pT1-4-xN1-3M0 93%, and in stage pT1-xN4M0/pT1-xN1-4M1 69%. Using a stage adapted target volume, the exclusive irradiation of the paraaortic nodes in the stage pT1N0M0 led to a cure-rate of 100%. Because of this result, and due to the improved tolerance and lower exposure to the remaining testis we recommend this method. The effectiveness of radiotherapy, also in advanced seminomas, the benefit of prophylactic mediastinal irradiation and the therapeutic modalities for treatment of extragonadal seminomas are discussed.

Cobalt Radioisotopes↗
PubMed1985

[Pancreaticopleural fistula formation: a rare complication in chronic pancreatitis].

Pleural effusions are found in 3 to 17% of patients with chronic pancreatitis. The most likely underlying pathogenetic mechanism is transdiaphragmatic lymphatic transfer of pancreatic secretions to the subpleural space, whilst a rare cause is the formation of pancreatico-pleural fistulae. The measurement of amylase activity in the pleural fluid has considerable diagnostic value and in most cases the diagnosis is verified by endoscopic retrograde pancreaticography (ERP). A case report is presented and forms the basis for a discussion of pathogenesis, diagnostic problems and therapeutic management of pleural effusions in chronic pancreatitis.

Chronic Disease↗
PubMed1984

[Tinidazole in the therapy of anaerobic pulmonary infections].

The purpose of the study in 10 patients with anaerobic lung infections was to demonstrate the efficacy of therapy with Tinidazole. In 9 patients, the clinical evaluation as well as X-ray and bacteriological evidence showed positive results of therapy, while in one patient a mixed anaerobic infection with Streptococcus an., Bacteroides frag., and Clostridium sp. was still present after the end of therapy. Side effects were not observed with Tinidazole therapy.

Bacteria, Anaerobic↗
PubMed1983

A comparative study of the efficacy of ceftazidime versus cefazolin and tobramycin in patients with acute exacerbations of chronic bronchitis.

Fifty-nine adult patients have entered this study. The initial pathogens were eradicated from the infection sites and all except two of the patients who were assessed clinically in the ceftazidime group and 4 cases in the comparative group were cured or improved. No adverse reactions were connected to ceftazidime or to tobramycin and cefazolin.

Adolescent↗
PubMed1983

[The stress reaction in knee operations under continuous peridural anesthesia in comparison with neuroleptanalgesia].

30 patients undergoing knee-operations were randomized in two groups. 15 patients were operated on under neuroleptanalgesia. Piritramid was given postoperatively. The other group of patients was operated under epidural analgesia, postoperatively they were kept painfree by continuous infusion of 0.2% bupivacaine via an epidural catheter at a rate of 0.2 ml/kg.h over a period of 24 h. The aim of our study was to find out if continuous epidural anaesthesia in contrast to neurolept analgesia was able to prevent the hormoneal and metabolic response to these painful operations. Plasma glucose, insulin, C-peptidee, glucagon, cortisol, human growth hormon, and beta-hydroxybutyric acid were measured before commencing anaesthesia (point 0), after induction (point N), at the end of operation (point Op) and 1, 2, 4, 6, 12 and 24 h postoperatively (point 1, 2, 4, 6, 12 and 24). In both groups of patients an intravenous glucose tolerance test was carried out after 24 h. There were significant differences between the two groups in plasma glucose, insulin, C-peptid and cortisol, indicating that the stress response can be mitigated by continuous epidural anaesthesia. These differences however were only found in the first few postoperative hours. After a period of 24 h there were no differences at all, the metabolic alterations as indicated by the pathological glucose tolerance test, were the same in both groups, independent of the anaesthetic method used.

3-Hydroxybutyric Acid↗
PubMed1983

[Amino acid loss and protein spectrum of the peritoneal dialysate during continuous peritoneal dialysis].

The loss of amino acids and the protein spectrum in the dialysate during continuous peritoneal dialysis were evaluated in 6 patients with normal kidney function in the context of a study on psoriasis therapy. On the 10th day the protein loss was lower than on the 1st day of therapy. The total loss of amino acids was only 0.6 g/day with a dialysate volume of 6 1/24 h and was thus lower than the losses quoted in the literature for an exchange volume of 10 1/24 h. As a whole the loss of amino acids apparently plays only a subordinate role as an influencing factor on protein metabolism in continuous peritoneal dialysis.

Adult↗