Biomedical subjects
Publications and source records attributed to H Eckert.
Rabbits developed after feeding with cholesterol and sunflower oil atheromatous changes. Pulmonary arteries exhibit in contrast to the aorta 1/5 of the intensity of atheromatous lesions. Atheroma were only seen in large and medium-sized pulmonary arteries with a twofold intensity in upper lobes in contrast to the lower lobes.
A short review of the different methods for light microscopic demonstration of phospholipids in the lung tissue is given. As shown in own experiments, the phosphomolybdic-acid-stannous-chloride reaction (Landing et al., 1952) appears as a successful method for rapid demonstration of phospholipids.
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Male rats showed 6 and 8 weeks after aerosol application of mineral oil and interstitial pneumonia, histiocytic foreign body reaction with foam cells and a focal emphysema. Relations to the correspondent human disease are shortly discussed.
Guinea pigs and mice, receiving subcutan injections of human Kveim antigen with and without previously application of BCG-vaccine, showed only in few cases histological pictures, bearing a great resemblance to the positive human Kveim-reaction.
The morphological changes were investigated by male rats after aerosol application of mineral oil above a period of three weeks. Beginning in the second week, there was a permanent increase of macrophages and foam cells in the alveolar septa and alveolar lumina in closed relation to the deposited mineral oil, visible by dark field illumination. The macrophages and foam cells showed a high activity of non-specific esterasis and acid phosphatasis whereas the activity of adenosine triphosphatasis clear decreased. In the third week the formation of focal granulomas started predominantly existing of histiocytes and only few foam cells.
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