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Biomedical subjects

H Deicher

Publications and source records attributed to H Deicher.

At least 181 records · Page 10Linked to original sources
PubMed1975

Detection of antibody to hepatitis Bs-antigen in patients with acute and chronic hepatitis as measured by a modified procedure of the radioimmunoassay Ausria I 125.

A simple modification of the radioimmunoassay Ausria I 125 was employed for detecting anti-HBs using the inhibition of a constant amount of HBs Ag. Anti-HBs was demonstrated in up to 82% of follow-up patients recovering from viral hepatitis B and in 79% of hemophilia patients. The antibody was found in 3.4% of healthy blood donors and in 10% of family contacts of patients with acute HBs Ag-positive viral hepatitis. The frequency of anti-HBs in 44 patients with HBs Ag-negative chronic aggressive hepatitis or cryptogenic liver cirrhosis (23%) did not differ significantly as compared with the occurrence of anti-HBs in 58 patients with chronic rheumatoid arthritis (16%). These findings give further support to the suggestion that the hepatitis B virus does not contribute to the aetiology of HBs Ag-negative chronic active hepatitis.

Acute Disease↗
PubMed1975

Anti-HBsAg assay using the Ausria system with standard antigen dilutions.

A simple modification of the radioimmunoassay Ausria I and Ausria II was employed for detecting anti-HGsAg using the inhibition of a constant amount of HBsAg. The highest incidence of anti-HGsAg was demonstrated in follow-up patients recovering from viral hepatitis B (82%) and in hemophilia patients (79%). Lower frequencies were observed in patients with chronic aggressive hepatitis or liver cirrhosis (23%), patients with chronic rheumatoid arthritis (16%), family contacts of patients with viral hepatitis B (10%) and blood donors (3.4%). No difference in sensitivity for the presence of anti-HBsAg was found between the Ausria I and the Ausria II test.

Antibodies↗
PubMed1975

[Elimination of rhesus (D)-incompatible erythrocytes by (Fab')2 G-anti-D (author's transl)].

The effectiveness of (Fab')2 G-Anti-D regarding elimination of D-incompatible fetal erythrocytes, and suppression of the formation of specific antibody, was investigated in 16 probands. Using 51Cr labelled D-incompatible fetal erythrocytes and simultaneous HbF-cell counting, fast elimination of incompatible red cells, and selective accumulation in the spleen, were observed after injection of small doses of (Fab')2 G-Anti-D. None of the probands showed active formation of anti-D after 3-12 months. The doses of the (Fab')2 G-Anti-D preparation used were similar to those employed in routine use of IgG-Anti-D. The results emphasize the importance of fast immunelimination of potentially antigenic red cells and thus point to a peripheral mechanism of anti-D prophylaxis by specific anti-D.

ABO Blood-Group System↗