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Biomedical subjects

H Degreef

Publications and source records attributed to H Degreef.

At least 163 records · Page 9Linked to original sources
PubMed1978

Yersinia enterocolitica as a cause of erythema nodosum.

54 cases of erythema nodosum, seen in the Department of Dermatology at the St. Raphael University Hospital, Louvain, were reviewed for their possible aetiology. A search for Yersinia enterocolitica (Y.e.) agglutinins was performed in 21 patients of whom 8 had significant serum antibody titres. These cases are presented and discussed. Gastro-intestinal symptoms, preceding by 2 weeks the erythema nodosum, are strongly suggestive for an aetiologic link with Y.e. Our observations confirm and extend to this part of Europe, the experience of other, mainly Scandinavian, authors.

Adolescent↗
PubMed1977

Turpentine-induced hypersensitivity to peppermint oil.

After a dental operation a former laboratory technician was referred to our clinic because of swelling of his tongue, lips, and gingival mucosa. Patch testing with the ICDRG standard test battery gave positive reactions to colophony, balsam of Peru, and turpentine peroxides. Further patch testing revealed hypersensitivity to peppermint oil (an ingredient of several dental preparations) due to the sensitizing properties of three ingredients: alpha-pinene, limonene, and phellandrene. These compounds also occur in turpentine oil, a substance used in the patient's laboratory.

Aged↗
PubMed1976

Woringer-Kolopp disease. An epidermotropic variant of mycosis fungoides.

Woringer-Kolopp disease is characterized by the presence of a monomorphic, tumorous infiltrate in the epidermis. A light- and electron microscopic study, and cytophotometry, of one case were performed and the results are discussed. No explanation has been found for the epidermotropic character of this condition, although an intraepidermal origin of the tumor infiltrate seems improbable. The cytomorphologic characteristics of the tumor cells shows a striking analogy to the atypical cells in the Sezary syndrome and mycosis fungoides. These findings support the hypothesis that Woringer-Kolopp disease represents a clinical variant of mycosis fungoides and the Sezary syndrome.

Aged↗
PubMed1975

Pseudomonas putrefaciens as a cause of infection in humans.

Pseudomonas putrefaciens, a strongly H2S-producing pseudomonad, was isolated from 10 human infections over a two-year period. In one patient the organism was repeatedly isolated from a phlegmone developing in the depth of a varicose leg ulcer. This is the first report on the occurrence of Ps. putrefaciens in humans outside the USA and the first to provide the detailed account of a clinical observation where the opportunistic pathogenic role of this unfamiliar organism has been sufficiently documented. Data are presented on the bacteriological properties and on the antibiotic sensitivity of Ps. putrefaciens.

Adult↗
PubMed1975

Miconazole nitrate in the treatment of dermatomycoses.

Miconazole nitrate was used topically in 83 dermatophytic and candidal infections. Complete cure was obtained in 81% of the cases. The in vitro studies made before, during and after treatment showed no evidence of resistance to the drug. The miconazole 2% cream and powder preparations were well tolerated. Only one case of sensitization was observed.

Administration, Topical↗
PubMed1971

The Werner syndrome.

Explore the source record for details and available documents.

Diagnosis, Differential↗
PubMedDate not supplied

Itraconazole in the treatment of dermatophytoses: a comparison of two daily dosages.

Itraconazole, the first orally active triazole antifungal agent, was tested in 185 cases of acute or chronic (recurrent) dermatophytosis. The skin infections were divided into two major diagnostic groups: tinea corporis/tinea cruris (91 cases) and tinea pedis/tinea manuum (94 cases). Each patient was randomly assigned to a regimen of 50 or 100 mg of itraconazole daily. Of the cases of tinea corporis and/or tinea cruris, 94% responded to 50 mg of itraconazole daily and 96% to 100 mg daily. The effects of therapy were evident earlier when 100 mg daily was given. Of the cases of tinea pedis and/or tinea manuum, 80% responded to 50 mg of itraconazole daily and 94% to 100 mg. Again, improvement was seen sooner with the 100-mg regimen. Only five patients (2.9%) reported minor adverse reactions. Hematologic and blood-biochemical parameters were monitored before treatment and at biweekly intervals thereafter in 37 patients; no significant abnormalities were observed. Thus, either 50 or 100 mg of itraconazole daily constitutes effective treatment for dermatophytoses. Since the larger dosage induces a faster response, it should be evaluated further.

Adolescent↗
PubMedDate not supplied

Fluticasone propionate: a rare contact sensitizer.

Fluticasone propionate is the first of a new generation of fluorinated corticosteroids that have been synthesized with a view to separating local activity from undesirable side effects. In recent years, contact allergy to the newer topical corticosteroids has received increasing attention. The results of patch testing with fluticasone propionate, even in patients with a known contact allergy to corticosteroids, argue for a low sensitization and cross-sensitization potential.

Administration, Topical↗
PubMedDate not supplied

[Contact eczema in patients with leg ulcers].

Patients with leg ulcers or varicose eczema suffer much more often from contact eczema due to the local application of pharmaceutical preparations than patients suffering from other dermatological problems (even those of eczematous origin). This contact allergy may concern not only the active ingredient but also the excipient, the preservative, or even the perfume. In all cases of leg ulcers, of varicose eczema, but also of badly healed ulcers, epicutaneous tests should be carried out with all the components of the pharmaceutical preparations concerned. Moreover, the pharmaceutical industry really must perfect non-allergenic preparations.

Administration, Topical↗