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Biomedical subjects

H Degreef

Publications and source records attributed to H Degreef.

At least 109 records · Page 6Linked to original sources
PubMed1986

Light on the persistent light reaction-photosensitivity dermatitis-actinic reticuloid syndrome.

In this article are reviewed the various hypotheses concerning the etiology of the persistent light reaction and photosensitivity dermatitis, which occurs among older people and is characterized by an extreme photosensitivity that sometimes evolves into a pseudolymphoma, that is, actinic reticuloid. An etiologic agent can sometimes be demonstrated, but the precise pathogenetic mechanism is unknown. Clinical experience and experimental research indicate that the cause is most probably multifactoral: contact allergenic, photoallergenic, phototoxic, immunologic, and metabolic factors are involved, but their precise roles in the origin of the extreme photosensitivity are still unclear. Localized persistent light reactivity could result from the continued effects of the original photoallergen, but generalized photosensitivity is more difficult to account for. Among the many different hypotheses, two are of special interest: autosensitization of skin proteins with endogenous photosensitizers and cellular hypersensitivity to light, as is manifested by fibroblast cultures of actinic reticuloid patients.

Allergens↗
PubMed1986

Itraconazole, a new orally active antifungal, in the treatment of pityriasis versicolor.

Itraconazole, a new orally active triazole antifungal, has been tested in patients with pityriasis versicolor. A comparison of different dose schedules was carried out in 73 patients. A regime of 100 mg itraconazole daily for 15 days gave a 100% response rate; 200 mg daily for 5 days gave an 80% response rate. Two patients, who had received 50 mg itraconazole for 14 days, relapsed within 2 months of finishing treatment. Only two patients reported minor side-effects.

Administration, Oral↗
PubMed1986

Contact allergy to hydrocortisone and thixocortol pivalate: problems in the detection of corticosteroid sensitivity.

Several of the difficulties involved in the detection of corticosteroid allergy are illustrated by the problems encountered in a patient sensitive to a preparation containing hydrocortisone and miconazole nitrate. The importance of appropriate concentrations and vehicles for patch testing, the possible rôle of impurities, and cross-sensitivity of corticosteroid molecules are discussed.

Administration, Topical↗
PubMed1986

Immunoelectron microscopic investigation of HLA-DR-positive dendritic cells at the dermo-epidermal junction in skin disorders associated with the deposition of immune complexes.

HLA-DR-positive dendritic cells present at the dermo-epidermal junction in skin disorders associated with the deposition of immunoglobulins and/or complement factors in the skin biopsy are investigated ultrastructurally. They demonstrate long, slender cytoplasmic processes, an indented nucleus, and strikingly dilated cisternae of the endoplasmic reticulum. HLA-DR antigen is present on the plasma membrane and within some of the dilated cisternae. These findings further support our previously formulated hypothesis that these cells represent a functionally active stage of antigen-presenting cells.

Antigen-Antibody Complex↗
PubMed1986

Expression of HLA-DR and T6 antigens on keratinocytes and dendritic cells. A comparative immunohistochemical study.

The number, morphology, and distribution of cells with dendritic processes in the epidermis and dermis, as well as the expression of HLA-DR and T6 antigen on keratinocytes in 66 skin biopsy specimens have been studied. In the epidermis, OKT6+ cells with slender dendritic processes predominated in the upper layers and outnumbered OKIa1+ cells with dendritic processes, which were only fragmentarily stained and present throughout all layers. In the dermis, OKIa1+ cells with dendritic processes outnumbered OKT6+ cells with dendritic processes. Cases showing keratinocytic positivity for OKIa1 contained very few epidermal OKIa1+ cells with dendritic processes; cases showing surface staining of keratinocytes with OKT6 contained high numbers of epidermal OKT6+ cells with dendritic processes. We suggest that OKT6 and OKIa1 label distinctive subpopulations of epidermal and dermal dendritic cells and, as such provide complementary data.

Antibodies, Monoclonal↗
PubMed1985

Ia+ dendritic cells lining the dermo-epidermal junction in bullous skin disorders, associated with the deposition of immune complexes.

Skin biopsies from 34 patients, presenting with a variety of bullous skin disorders were investigated, using routine light microscopy and immunohistochemistry. In bullous skin diseases characterized by deposition of complement factors (CF) and/or immunoglobulins (Ig), a monolayer of OKIa+1, OKT-6, OKM-1 dendritic cells was found at the dermo-epidermal junction. Retrospectively, these cells were easily recognized on paraffin embedded, H & E stained material. In bullous skin disorders, showing no deposition of CF and/or Ig, this monolayer of dendritic cells was lacking. It is suggested that these OKIa+1, OKT-6, OKM-1 dendritic cells at the dermo-epidermal junction represent some type of antigen presenting cells, not corresponding to Langerhans cells, veiled cells or indeterminate cells.

Antibodies, Monoclonal↗
PubMed1985

Standardizing 8-methoxypsoralen plasma profiles by using an emulsion form.

Uniform 8-methoxypsoralen (8-MOP) absorption from the gastrointestinal tract is necessary to avoid day-to-day variations in 8-MOP plasma levels when treating patients with psoriasis by photochemotherapy. Because of its low water solubility, particle size and crystal form of the 8-MOP can significantly influence its bioavailability. The presentation form is also important, as is shown by the present study in which 8-MOP plasma levels were compared in thirty patients after oral administration in three different forms: formulation A consisted of gelatin capsules containing 8-MOP with a mean particle size of 200 mu; formulation B consisted of gelatin capsules containing 8-MOP in microcrystalline form with particle size between 20 mu and 30 mu; formulation C contained the same microcrystalline 8-MOP but in an emulsion base. Significantly higher plasma levels were found with formulations B and C than with formulation A. Furthermore, the individual differences in plasma profiles were markedly less with the emulsion base than with the capsule forms. Therefore, the clinical use of 8-MOP in emulsion form would constitute a major step in 8-MOP dose standardization and could lead to better control of subjective side effects and better therapeutic results.

Emulsions↗
PubMed1985

Patch testing with silver sulfadiazine cream.

23 patients who had used silver sulfadiazine cream were patch tested. No reactions to the active principle occurred but 2 vehicle components, cetyl alcohol and propylene glycol, were positive. No sulfonamide-sensitive subject reacted to silver sulfadiazine. There is no evidence that silver sulfadiazine has a contact sensitizing potential or that it is contra-indicated for patients with a history of sulfonamide hypersensitivity.

Cross Reactions↗
PubMed1985

Pustular reactions to hexafluorosilicate in foam rubber.

A case is reported of a foam rubber carrier with pustular lesions on the arms, wrists, thighs and trunk. Scratch and patch testing with the foam rubber components was negative. Animal testing revealed sodium hexafluorosilicate (Na2SiF6), one of the ingredients of the foam rubber, to be a pustulogen on previously damaged skin.

Adult↗