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Biomedical subjects

H Dean

Publications and source records attributed to H Dean.

At least 37 records · Page 2Linked to original sources
PubMed1986

Metabolic response to insulin induced hypoglycaemia in lean and obese subjects.

Metabolic response to insulin induced hypoglycaemia was examined in 8 lean and 11 obese subjects. The metabolic rate increased in lean and obese subjects during the hypoglycaemia. The mean response (as the sum of all the values above basal) was not significantly different between lean and obese subjects. The mean decrease in blood glucose and the mean hormonal response (increase in cortisol, adrenaline and noradrenaline) were not different between lean subjects and obese subjects. However, the metabolic response and noradrenaline response were variable in obese subjects and some obese subjects showed a poor response. These results suggest that in some obese subjects, there may be reduced thermogenic response to insulin induced hypoglycaemia.

Adult↗
PubMed1985

Maternal and cord blood glycated albumin and total serum proteins: correlation with maternal glycemic control and birth weight.

Maternal and cord blood glycated albumin and total protein levels were measured in three groups: normal women (nondiabetic women who gave birth to infants that were normal for gestational age), test women (women who had no evidence of glucose intolerance with screening procedures and who gave birth to large for gestational age infants), and women with gestational diabetes. In all cases the cord glycated albumin and total protein levels were 20% to 30% less than the corresponding maternal levels, and no correlation could be detected between cord and maternal blood concentrations. There was no significant difference in cord and maternal glycated albumin and total protein levels among the three groups, although there was a slight upward trend detected in the test and diabetic groups. There was no significant correlation between birth weight ratio and either cord or maternal values for any of the groups except the diabetic cord samples, where a significant negative correlation between glycated albumin and total protein and birth weight ratios was found. The implications of these findings are discussed in respect to the usefulness of cord and maternal glycated albumin and total protein in retrospective screening for gestational diabetes.

Adult↗
PubMed1985

Cord blood glycosylated (glycated) hemoglobin: correlation with maternal glycosylated (glycated) hemoglobin and birth weight.

Maternal and cord blood glycosylated hemoglobin levels were measured by an affinity chromatographic method in three groups: normal women (nondiabetic women who gave birth to infants that were normal for gestational age); test women (women who had no evidence of glucose intolerance with screening procedures and who gave birth to large-for-gestational age infants); and women with gestational diabetes. In all cases the level of cord blood glycosylated hemoglobin was approximately 40% less than the corresponding maternal blood levels, and no correlation could be detected between maternal and cord blood concentrations. The reference range for glycosylated hemoglobin in the normal maternal population was similar to that for nonpregnant adults. There was no significant difference in cord and maternal glycosylated hemoglobin levels among the three groups, although a slight upward trend was detected in the diabetic group. There was a lack of correlation of cord and maternal glycosylated hemoglobin with birth weight in all three groups. The implications of these findings are discussed in respect to the usefulness of cord and maternal glycosylated hemoglobin in retrospective screening for gestational diabetes.

Adult↗
PubMed1985

Unusual QRS morphology associated with transvenous pacemakers. The pseudo RBBB pattern.

Eleven patients with implanted pervenous pacemakers were found to have unusual QRS morphology resembling right bundle branch block (RBBB) on the 12-lead electrocardiogram. In nine patients, the tip of the electrode catheter was established with certainty to be in the right ventricular apex. In eight of the nine, the standard leads showed a left bundle branch block pattern (LBBB), whereas only the precordial leads V1 and V2 resembled RBBB. In only one of the nine was the RBBB pattern also seen in the standard leads. In all nine, recording the precordial leads one intercostal space below the usual space eliminated the RBBB pattern in V1-V2 and resulted in inscription of a QS complex, whereas recording the leads one space higher than usual enhanced the height of the R wave. This is explained by the marked superior and slight anterior orientation of the main QRS complex in right ventricular pacing. It is suggested that the pattern of RBBB in V1-V2 + LBBB in lead 1 be named pseudo RBBB pattern since it does not represent left prior to right ventricular activation.

Bundle-Branch Block↗
PubMed1985

Echocardiographic findings of mitral and tricuspid valve prolapse in primary pulmonary hypertension.

Echocardiographic findings in six patients with primary pulmonary hypertension are presented. Four of six patients had abnormal septal motion with prolapse of mitral and tricuspid valves. The other two had none of the three echocardiographic abnormalities. It is possible that hemodynamic changes in ventricular pressure gradients across the interventricular septum cause an abnormal septal motion and secondary AV valve prolapse.

Adolescent↗
PubMed1984

A new form of insulin resistance with growth retardation, fatty liver, and hypogonadotropic hypogonadism.

A 17-year-old boy presented with growth retardation, marked hepatomegaly, and sexual infantilism. Elevated fasting serum insulin levels and a blunted hypoglycemic response to exogenous insulin (up to 0.35 unit/kg) demonstrated severe insulin resistance. Neither anti-insulin nor anti-insulin receptor antibodies were present. The molecular size of his circulating insulin and its binding to IM-9 lymphocytes was normal. Despite high circulating insulin values, both erythrocytes and cultured skin fibroblasts showed normal insulin binding capacity and affinity. Tissue responsiveness was examined by measuring the insulin-induced increase in 2-deoxyglucose uptake into fibroblasts. Although the basal glucose transport rate was slightly lower than that of controls, the insulin-induced increase was normal. However, the normal increase in thymidine incorporation in response to insulin was blunted, as were the thymidine incorporation responses to epidermal growth factor and fibroblast growth factor. These studies demonstrate the possible existence of a new form of post-insulin receptor defect as a cause of insulin resistance, but underscore the difficulty that exists in defining the exact nature of the defect in these disorders.

Adolescent↗
PubMed1983

Serial two-dimensional echocardiography in infective endocarditis of the pulmonic valve.

Infective endocarditis was diagnosed in a 15-yr-old patient following closure of a patent ductus arteriosus several weeks previously. Pulmonic valve vegetations were detected by both M-mode and two-dimensional echocardiograms. The serial echocardiographic examinations revealed the emergence of a vegetation on the pulmonic valve, a marked decrease in its size subsequent to pulmonary embolism, reemergence of a vegetation upon relapse of the disease and its resolution 4 mo later. The echocardiographic findings and their correlation to the various stages of the disease are described.

Adolescent↗
PubMed1981

Concealed quadrigeminy.

Concealed quadrigeminy has been observed in a 24-year-old pregnant woman without apparent heart disease during 10-hour Holter monitoring; in a 33-year-old female with prolapse of the mitral valve during 0.5-hour continuous electrocardiographic recording, and in an 80-year-old man with anterior myocardial infarction. In all these continuous electrocardiographic recordings 391, 437, 25 consecutive interectopic intervals were correlated and the number of sinus beats in each interval fitted the formula s=4n - 1. The 2nd case showed a variant of concealed quadrigeminy. The number of sinus beats in 9 interectopic intervals fitted the formula s=4n when the first ectopic beat of the interval was interpolated and did not interfere with the propagation of the next first sinus beat.

Adult↗
PubMed1976

Some factors affecting the measurement of blood inorganic phosphorus in cattle.

Sixty cows were studied over 3 days, to determine the effect of site of sampling, handling stress and the tranquilliser xylazine hydrochloride, on blood inorganic phosphorus (P). Jugular venous and coccygeal mixed arterial and venous blood were compared. Saliva was also analysed for P. Buffered and unbuffered trichloracetic acid (TCA) were compared as deproteinising agents. Tail blood P was consistently 12% (range 7-17%) higher than that from the jugular vein (P less than 0.01). This difference decreased when jugular blood was sampled first but increased following administration of the tranquilliser. The drug significantly (P less than 0.01) increased the concentration of P in the saliva on 2 out of 3 days. The possible role of salivary P in affecting jugular P values, is discussed. The buffered TCA analyses gave consistently lower P readings than the unbuffered analyses. The magnitude of this effect was time dependent, being greater when the samples were left for 4 days (P less than 0.05) than when analysed the next day. There was a very strong correlation between plasma and whole blood P. It was concluded that the tissue of choice in phosphorus studies is tail blood (plasma or serum) treated with buffered TCA.

Animals↗