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Biomedical subjects

H Chmielewski

Publications and source records attributed to H Chmielewski.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Electromyographic studies of plantar-mental reflex].

The authors investigated the electromyographic response to mechanical stimulation of the palmar skin (palmo-mental reflex) and plantar skin (planto-mental reflex) in the mentalis muscle. The palmo-mental reflex was present in EMG in all 22 healthy subjects an in 51 cases of 51 cases of limited cerebral lesions. The planto-mental reflex was absent in healthy subjects, but it was found in 14 out of 31 cases of focal brain injury and in 2 out of 20 cases with diffuse lesions. The planto-mental reflex is a pathological reflex appearing mainly in severe focal cerebral lesions. No description of this reflex was found in the available literature.

Adult↗
PubMedDate not supplied

[Increased percentage of "double phenotype" form T lymphocytes in blood of patients with multiple sclerosis].

We studied the percentage of double positive (CD4+CD8+) form of T-cells in a group (total 77) multiple sclerosis (MS) patients, measured by means of monoclonal antibodies anti-CD3, CD4/FITC, CD8/RPE and flow cytometry FACScan (Becton Dickinson). In our study we have shown that the percentage of the double positive T cells is higher (p < 0.05) in the peripheral blood of patients with acute exacerbation of MS (n = 21), and in the course of chronic progressive MS (n = 27) comparing to MS remission (n = 29) and other neurological diseases (n = 25) groups. In the study we have shown that the percentage of double positive T-cells in peripheral blood depends mainly on disease activity.

Adult↗
PubMedDate not supplied

[Effect of gamma radiation on selected indicators of oxygen metabolism in erythrocytes of patients with multiple sclerosis].

The aim of the work was to study certain parameters of aerobic metabolism in the erythrocytes of multiple sclerosis patients and healthy controls after exposure of the erythrocytes to ionising radiation. The group of patients included 32 cases (17 women and 15 men) aged 19-54 years. The control group comprised 60 healthy subjects (28 women and 32 men) aged 19-56 years. The erythrocytes were exposed at +20 degrees C in contact with air during 50 minutes. The source of gamma radiation was 60 Co of 1.33 MeV energy and 10 Gy/min yield. In the erythrocytes of the patients the activity of the antioxidative enzymatic system was reduced, with decreased activity of superoxide dismutase (SOD-1) and glutathione peroxidase (GPx) and with increased level of malonyl dialdehyde (MDA) at the same time gamma radiation as an additional source of free radical generation increased the changes of these biochemical parameters which suggested a greater susceptibility of multiple sclerosis erythrocytes to oxidative stress.

Adult↗
PubMedDate not supplied

[Superoxide dismutase (SOD-1) activity in erythrocytes of patients with multiple sclerosis].

The purpose of the study was determination of the activity of superoxide dismutase (SOD-1) in the erythrocytes of multiple sclerosis patients taking into consideration certain aspects of the disease, such as its duration, clinical form and course, age and sex of the patients. The study included 34 patients (17 males and 17 females) aged 19 to 56 years. The control group comprised 64 healthy subjects (25 females and 38 males) aged 19-59 years. A significant reduction was found of SOD-1 activity in the erythrocytes of the patients which may suggest a lower enzymatic defense mechanisms against oxidative stress. No difference in the activity of SOD-1 was found between clinical forms and different courses of the disease, although the activity changed in relation to age, sex and disease duration.

Adult↗
PubMedDate not supplied

[Effect of the treatment with adrenocorticotropic hormone on the 2,3-diphosphoglycerate level in the erythrocytes of patients with multiple sclerosis].

The reported study was carried out in 20 patients with multiple sclerosis (12 women, 8 men) aged 23 to 54 years, with disease duration from 3 to 20 years. The patients were treated with the preparation ACTH-Polfa 2000 mg for one treatment course. The patients were divided into subgroups considering the age, disease duration, clinical form and clinical course of the disease. The control group comprised 22 healthy subjects (10 women and 12 men) aged from 22 to 41 years. The concentration of 2,3-diphosphoglycerate in the erythrocytes was determined by Bartlett's method twice: before and after ACTH treatment. Before the treatment the concentration of 2,3-DPG in the erythrocytes of the patients was not different from that in the controls, but after the treatment this concentration was significantly increased in all groups. It was demonstrated, furthermore, that 2,3-DPG concentration in the erythrocytes could change before ACTH treatment depending on the age of the patients and the clinical course of the disease.

2,3-Diphosphoglycerate↗
PubMedDate not supplied

[cAMP and cGMP in the cerebrospinal fluid of patients with multiple sclerosis].

The authors studied the changes in cAMP and cGMP concentrations in the cerebrospinal fluid in 38 patients with multiple sclerosis. A statistically significant fall of cAMP was observed with a simultaneous rise of cGMP in the initial stage of the disease as compared with the control group. In the later course of the disease and development of various clinical forms of multiple sclerosis the pattern of these changes was not characteristic.

Adolescent↗
PubMedDate not supplied

[Inositol in the cerebrospinal fluid, plasma and erythrocytes in spinal pain syndromes].

The studies, performed on 40 patients with brachialgia and ischialgia syndromes, showed higher CSF inositol concentrations in comparison with healthy subjects. The highest rise was observed particularly in patients in the initial stage of disease, while the rise was lower in more severe forms of the disease and in cases with root compression confirmed by radiculography. Blood plasma and erythrocyte concentrations of inositol and phosphatidylinositol were within normal range, although they significantly differed in various brachialgia and ischialgia syndromes.

Back Pain↗
PubMedDate not supplied

[Activity of various lysosomal hydrolases in peripheral blood granulocytes in patients with multiple sclerosis].

The activity of acid phosphatase, acid and neutral proteases in the serum, white blood cells and lysosomal granules and in the supernatant of the lysosomal fraction of peripheral blood granulocytes was determined in 33 patients with multiple sclerosis. The control group included 20 clinically unaffected subjects. A rise in the activity of neutral proteases in white blood cells was demonstrated at the time of multiple sclerosis exacerbations and a fall in the activity of these enzymes in lysosomal granules with its simultaneous rise in the supernatant of the lysosomal fraction of granulocytes was observed.

Acid Phosphatase↗
PubMedDate not supplied

[Suppressor cell activity in multiple sclerosis and other nervous system diseases. Preliminary report].

3H-Thymidine incorporation was assessed in concanavalin A-stimulated cultures of peripheral blood lymphocytes of healthy subjects and multiple sclerosis patients. At the same time the counts of T and B lymphocytes were determined in peripheral blood and the activity of suppressor cells was determined in vitro by the method of Shou et all. in these patients and in other neurological diseases. The studied immunological parameters showed some variability in patients with multiple sclerosis: at the time of exacerbations the activity of suppressor cells decreased and the mitogenic response to Con A was impaired. In remissions and in slowly progressive cases of multiple sclerosis the activity of suppressor cells was increased, particularly in elderly patients. The reported investigations demonstrated that disturbances in the functions of suppressor cells occur also in other neurological diseases. The role of the observed disturbances in the pathogenesis of multiple sclerosis is discussed.

Adult↗
PubMedDate not supplied

[Myeloscintigraphic findings in a case of intradural leptomeningeal cyst].

The authors report the application of myeloscintigraphy in a case of intradural leptomeningeal cyst. Only 16 such cases have been described as yet in world literature. Myeloscintigraphy was found in this case a more objective and accurate method than myelography and permitted not only the compressing mass to be recognized but it determined also the upper and lower limits of the mass which is important for surgical intervention.

Adult↗