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Biomedical subjects

H Brynger

Publications and source records attributed to H Brynger.

158 records · Page 9Linked to original sources
PubMed1977

Graft survival and blood transfusion.

The outcome of primary kidney transplantation in 244 patients was studied with reference to pre-transplant blood transfusions. Fifty-eight patients received kidneys from living related donors with one shared HLA-haplotype, 186 patients received kidneys from cadaveric donors. Graft survival was found to be significantly poorer in non-transfused patients, especially in patients receiving kidneys from living related donors. The degree of uraemic intoxication did not seem to influence the outcome.

Adolescent↗
PubMed1977

Factors influencing the prognosis in diabetic patients accepted for renal transplantation.

Out of 27 patients with advanced diabetic nephropathy accepted for renal transplantation. 11 had cardiac symptoms and 10 others had advanced neuropathy. The former group had a poor outcome with 100% mortality within one year, seven patients dying before transplantation. Neuropathy also indicated a poor prognosis. Early transplantation, before the stage of terminal uraemia, was at no advantage in this material.

Adult↗
PubMed1977

HLA-ABC matching and outcome of primary cadaveric kidney transplantations in Gothenburg.

The influence of HLA matching was studied in 319 informative cases of primary cadaveric kidney transplantations performed in Gothenburg 1969--1976. Foreign HLA-B antigens seemed to be of more importance for graft survival than foreign HLA-A or -C antigens. The prognosis for graft survival was significantly improved for match-grades with one foreign HLA-B antigen from the period 1973--1976 compared to those from the period 1969--1972. Match-grades with two foreign HLA-B antigens had significantly reduced graft survival during the period 1973--1976.

Cadaver↗
PubMed1977

Blood transfusion and primary graft survival in male recipients.

The outcome of primary kidney transplantation in 241 male patients was studied with reference to pretransplant blood transfusions. 55 patients received kidneys from living related donors with one shared HLA-haplotype, 186 patients received kidneys from cadaveric donors. The graft survival was calculated after exclusion of graft loss due to non-immunological reasons. The graft survival was found to be significantly higher in transfused recipients, especially in patients receiving kidneys from living related donors.

Blood Transfusion↗
PubMed1977

Clinical experience with antilymphocyte-globulin in cadaveric kidney transplantation.

Two different commercially available anti-lymphocyte-globulin preparations have been used in 30 recipients of primary cadaveric kidneys. No difference in graft survival was found within three years after transplantation compared to 102 primary cadaceric kidney recipients who only received basic immunosuppression. When only patients completing an intended ALG dosage were considered, the one-year graft survival was 65% compared to 52% in patients not receiving ALG. In this series of ALG treated patients no major benefits were found compared to the basic immunosuppressive regimen used at this transplantation centre.

Antilymphocyte Serum↗
PubMed1975

Glucagon and insulin release from the allografted canine pancreas.

Six previously pancreatectomized dogs were transplanted with duct-ligated, pancreatic allografts. Glucagon and insulin levels in the venous outflow from the graft and in the systemic circulation were determined during the first 60 minutes after transplantation. Two of the dogs were subjected to L-arginine stimulation 5 days after transplantation and the glucagon levels in the venous outflow from the graft were determined. The glucagon and insulin concentrations increased rapidly after transplantation, describing a biphasic curve. In response to L-arginine stimulation, an increased glucagon release was observed.

Animals↗
PubMed1975

Function of the duct-ligated canine pancreatic allograft.

Heterotopic transplantation of a duct-ligated canine pancreas was performed in 20 previously pancreatectomized, non-related recipient dogs. A technical procedure was elaborated for this grafting. It was found that early, fatal postoperative bleeding in the recipient could be avoided when the interval between pancreatectomy and transplantation was reduced from 7 to 2-4 days. The early endocrine function was studied in 15 surviving animals by determination of blood glucose and serum insulin during fasting and during glucose load. 24 h after transplantation the blood glucose values were normal and 4-8 days after transplantation the glucose tolerance was within normal limits. The serum insulin was on a supranormal level, also during glucose load. The early endocrine capacity of the transplanted duct-ligated pancreas after transplantation was found to be satisfactory, restoring the blood glucose in the pancreatectomized recipients to normal levels.

Animals↗
PubMed1975

Behaviour of the duct-ligated canine pancreas during hypothermic albumin perfusion.

The behaviour of eight duct-ligated canine pancreata was studied during 23 hours of continuous, hypothermic perfusion, with an albumin electrolyte solution. The organs developed a considerable oedema during perfusion. This did not seem to influence on the vascular resistance of the organs. A continuous insulin release, a moderate increase in LDH concentration and only small changes in the electrolyte concentrations were observed in the perfusate, indicating only a moderate degree of cellular damage.

Albumins↗
PubMed1975

Twenty-four-hour preservation of the duct-ligated canine pancreatic allograft.

Twenty previously pancreatectomized dogs received a duct-ligated pancreatic allograft; 16 of the grafts were preserved for 24 h, 9 with continuous hypothermic albumin perfusion, 7 with simple hypothermic storage; 4 glands were transplanted immediately and served as controls. The outcome of preservation was assessed by studying the early endocrine function of the glands. Excluding five early failures due to bleeding, all grafts showed endocrine activity after transplantation and the glucose values were on a normal level. An initial hyperglucemia caused by pancreatectomy disappeared within 24h. In the two groups with 24h preservation, no differences in graft function were found. In the control group, there was a hypoglucemic tendency the first days after transplantation and a prolonged hyperinsulinemia during glucose load. It could be concluded that duct-ligated, isolated canine pancreas well tolerated 24h of preservation both by continuous hypothermic albumin perfusion and by simple hypothermic storage in an extracellular type of fluid.

Animals↗
PubMed1975

Studies on the duct-ligated pancreas as allograft for islet cell function.

Twenty previously pancreatectomized dogs were heterotopically transplanted with duct-ligated allografts. Sixteen of the grafts were preserved for 24 hours, nine with continuous hypothermic albumin perfusion, seven with hypothermic storage. Five dogs died from early postoperative bleedings. Fifteen surviving dogs had a satisfying endocrine function assessed by blood glucose and serum insulin during fasting and after glucose load. In six dogs the glucagon release from the graft was investigated and significant release was evident in all dogs. A high release was found after L-arginine stimulation. The endocrine function was satisfying after 24 hour preservation both with hypothermic storage and continuous hypothermic albumin perfusion. During such perfusion the pancreas became very oedematous. This did not influence on the outcome of the transplantation. The grafts were enlarged four to eight days after transplantation. Oedema, fibrotic changes and collagen depositions in the interstitial tissue were observed in light microscopy. These changes seemed to come earlier in glands preserved for 24 hours. Islet cells were identified in all functioning grafts and seemed histopathologically and ultrastructurally unchanged. A duct-ligated pancreatic segment was allografted to one diabetic patient in a pilot experiment. There was a satisfying endocrine function for 40 days. After that the graft became necrotic due to thrombus formation.

Amylases↗
PubMed1975

Morphological studies of the duct-ligated canine pancreatic allograft in the early period after transplantation.

Eighteen previously pancreatectomized dogs were transplanted with duct-ligated pancreatic allografts. Fourteen grafts were preserved for 24 hours with either continuous hypothermic perfusion or simple hypothermic storage. Four grafts were immediately transplanted. Azathioprine was given as sole immunosuppressive treatment. Three dogs died from early post-operative bleeding. The remaining 15 animals had an adequate endocrine function. After four to eight days the gross appearance was registered and the histopathological changes of the graft were studied with light and electron microscopy. The grafts were enlarged and of a firm consistency. Light microscopically the inter-lobular septa and the interstitial tissue showed an inflammatory reaction with oedema and fibroblastic proliferation. Collagen deposition was found after five days. In spite of an inflammatory reaction of the grafts, islets of normal appearance were recognized both light and electron microscopically which corresponded to an adequate endocrine function. In the 24-hour preserved glands fibrosis seemed to appear earlier and a smaller number of islets were recognized than in the immediately transplanted glands.

Animals↗
PubMedDate not supplied

Transplantation of a duct-ligated pancreatic allograft to a diabetic patient.

A 52-year-old man with an extremely instable insulin-treated diabetes mellitus, were transplanted with a duct-ligated pancreatic segment from a brain-dead donor. The graft showed immediately a satisfying endocrine function. The blood glucose levels were normalized and no exogenous insulin was administered. After five days a clear fluid with high contents of protein and high concentration of amylase started to drain from the wound. The drainage ceased spontaneously after 30 days. On day 41 after transplantation, the function of the graft suddenly stopped. At exploration, the graft was found thrombotized but with a well preserved architecture, and the oversewn end of the graft was intact. The patient is back on insulin treatment, and he is in the same condition as before the transplantation.

Amylases↗