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Biomedical subjects

H Brauman

Publications and source records attributed to H Brauman.

At least 37 records · Page 2Linked to original sources
PubMed1980

Synovial fluid beta 2 microglobulin and hydroxyproline fractions in rheumatoid arthritis and nonautoimmune arthropathies.

Fourteen patients with classical and definite seropositive rheumatoid arthritis (RA), 5 patients with microcrystalline arthritis, and 7 patients with osteoarthrosis were studied with respect to markers of newly synthesised collagen (synovial NDOH pro levels); markers of connective tissue resorption (synovial DOH pro and NBH levels); markers of lymphoid tissue activity (synovial and plasma beta 2m levels). Higher amounts of NDOH pro in RA synovial fluid are compatible with the hypothesis of a local connective tissue production as suggested by Uitto et al. on basis of a higher protocollagen proline hydroxylase activity in RA synovial tissue. DOH pro and NBH do not differ significantly in synovial fluid from RA or gouty patients, but the correlations between these forms of OH pro and, respectively, synovial lymphocytes and polymorphonuclear leucocytes are indicative of different processes of connective tissue remodelling in the 2 conditions. Synovial beta 2m levels are a direct function of total synovial lymphocyte counts independently of the type of arthropathy being explored. The ratio of synovial to plasma beta 2m is systematically above unity in RA patients only.

Arthritis, Rheumatoid↗
PubMed1980

Growth hormone after TRH in women with depressive illness.

Plasma growth hormone (GH) release after TRH injection was investigated in 27 unipolar and 23 bipolar depressive women, and in 39 normal female controls matched for age, sex and menopausal status. Peaks of GH secretion after TRH were observed in some depressive patients as well as in some normal controls, but there were no significant differences in GH response after TRH administration between patients and controls. The implications of these findings are discussed in reference to such factors as non-specific stress responses and abnormal neuroendocrine circadian rhythms in affectively ill patients.

Adult↗
PubMed1979

Disturbed mineral metabolism in hyperthyroidism: good correlation with tri-iodothyronine.

Mineral metabolism is frequently disturbed in hyperthyroidism. In a group of seventy-two patients with hyperthyroidism, we observed an increase in serum diffusible calcium in 50% of the cases, elevated inorganic phosphorus in 30% and elevated alkaline phosphatase in 44% of the cases. Correlations existed between the values of diffusible calcium, inorganic phosphorus, alkaline phosphatase and certain indices of thyroid function (T4, FT41, T3, FT3I), of which that with T3 was the best (P less than 0.001). Our results suggest that the magnitude of the disturbances of mineral metabolism depends on the severity of the hyperthyroidism and that it is the T3 level that constitutes the best index of that severity.

Adolescent↗
PubMed1979

Effect of rapid variation of renal function on plasma calcitonin and parathyroid hormone in man.

Plasma levels of immunoreactive calcitonin (iCT) and parathyroid hormone (iPTH) have been measured sequentially in 6 patients following successful renal transplantation (RT) and in 3 patients during the recovery phase of acute renal failure (ARF). iCT and iPTH returned to normal values within a few days when glomerular filtration improved; both hormones rose in cases of acute graft rejection. Unlike iPTH iCT did not follow closely the variations of creatinine, iCT even rising before creatinine in one graft rejection. These observations could possibly be explained by a dissociation between the renal metabolism of iCT and the glomerular filtration.

Acute Kidney Injury↗
PubMed1979

Cardiovascular effects of methyl methacrylate monomer.

Although cardiorespiratory human sensitivity to circulating methyl methacrylate monomer remains unknown, it is clear that the blood levels responsible for cardiocirculatory alterations in intact dogs are not obtained after insertion of acrylic cement in long bones in clinical practice. Circulating monomer considered as the sole causal factor for the hemodynamic changes described during orthopedic method is highly questionable.

Animals↗
PubMed1978

Parathyroid hormone-like biological activity in urine.

1. The parathyroid hormone-like biological activity of concentrated urine was measured by the increase of plasma calcium concentration after intravenous injection of the sample into chickens. 2. Urine was tested in hypoparathyroid patients, normal volunteer subjects, primary hyperparathyroid patients before and after surgery and patients with secondary hyperparathyroidism. 3. In primary and secondary hyperparathyroidism the biological activity was significantly higher than in urine from normal subjects, which was in turn significantly higher than the activity in the urine of hypoparathyroid patients. This bioactivity diminished after surgical removal of a hyperparathyroid adenoma. 4. Decreased activity after trypsinization indicated the peptidic nature of the hypercalcaemic substance.

Animals↗
PubMed1978

Plasma and urinary levels of beta2 microglobulin in rheumatoid arthritis.

Plasma and urinary levels of beta2 microglobulin have been investigated in 21 patients suffering from rheumatoid arthritis (RA). Despite a normal renal glomerular function in all patients 50% of them had supranormal plasma beta2 microglobulin levels and 30% had a higher than normal urinary output of beta2 microglobulin generally related to the high plasma level. Plasma beta2 microglobulin levels paralleled closely the lymphocytosis and the 'joint count' both indexes of the severity of the disease. beta2 Microglobulin was normally secreted by the lymphoid tissue and it is suggested that it reflects the increase of the total mass and/or membrane turnover of the lymphoid tissue in RA. beta2 Microglobulin may be considered as a good parameter of the degree of severity of the joint and extra-articular involvement as well as a useful tool for the evaluation of drug efficacy in rheumatoid arthritis.

Adult↗
PubMed1978

Parathyroid hormone and calcium blood levels in acute renal failure. With special reference to one patient developing transient hypercalcemia.

Parathyroid hormone (PTH), creatinine, calcium and phosphate blood levels were repeatedly measured in 5 patients with acute renal failure. 1 patient developed hypercalcemia during the recovery phase of the illness. PTH was elevated in all cases before starting hemodialysis treatment and returned to normal when renal function recovered. Calcium and PTH were inversely correlated in 3 patients including the patient with transient hypercalcemia. These data show that parathyroid function in acute renal failure is closely related to changes in renal function and the hypercalcemia, when occurring, is not necessarily due to parathyroid hyperactivity.

Acute Kidney Injury↗
PubMed1978

[beta2-Microglobulin in renal transplanted patients (author's transl)].

Plasma beta2m has been measured frequently during long term follow-up of kidney transplanted outpatients. The ratio of beta2m/log creatinine was abnormally high in 15 patients of this series bearing a symptomatic hepatitis independently of any modification of immunodepressive drug administration schedule (azathioprine and corticoids). The true effect of azathioprine could not be isolated whereas corticotherapy modified clearly the beta2m/creatinine ratio : increase of dosage for rejection resulted in a fall of the ratio whereas fast reduction increased the ratio acting essentially on circulating beta2m level (12 cases). The beta2m/creatinine ratio was normal or occasionally diminished in the 22 patients having an uneventful clinical course. Six patients showed mixed effects of hepatitis and variation of corticoid dosage and 7 cases were too much intricated to permit a good analysis of the data.

Adrenal Cortex Hormones↗
PubMed1978

[beta2-Microglobulin in synovial fluid (author's transl)].

In a series of patients with rheumatoid arthritis we found higher levels of synovial beta2-microglobulin (5,2 +/- 3 mg/l) than in gouty arthritis (2,4 +/- 0,6) or osteoarthritis (1,2 +/- 0,3 mg/l). The ratio of synovial/plasma beta2-microglobulin was always superior to unity (2,3 +/- 0,7) in the R.A. patients whereas it is always inferior to unity in the other groups. The correlation between plasma or synovial beta2-microglobulin and synovial lymphocyte count was highly significant in all cases in RA patients plasma and synovial beta2-microglobulin are significantly related to the degree of joint involvement as expressed by the joint count.

Arthritis, Rheumatoid↗
PubMed1977

Metabolism of human PTH by the kidney and the liver.

Immunoreactive PTH was measured by amino terminal and carboxyl terminal specific assays in the femoral artery, the right renal vein and the suprahepatic vein of ten hyperparathyroid patients. A marked arterio venous difference for amino terminal immunoreactivity was observed in the kidney and the liver. In contrast, the arterio venous difference for carboxyl terminal immunoreactivity was small in the kidney and not significantly in the liver. It is concluded that intact PTH and possibly amino terminal fragments of the hormone are metabolized by the kidney and the liver. Considering the fact that a carboxyl terminal specific antiserum is also capable of recognizing intact hormone, the finding of a small positive arterio venous difference for carboxyl terminal immunoreactivity does not permit us to exclude the possibility that the kidney and/or the liver are capable of generating carboxyl terminal fragments.

Adenoma↗
PubMed1977

Effect in vitro of ioglycamide on blood proteins and paraproteins.

No modification of plasma or serum viscosity was observed after in vitro addition of ioglycamide in a series of 160 healthy subjects and 1 467 patients including 33 cases of IgM paraproteinemia, 20 with Waldenström's disease. The labelled contrast medium never bound to paraproteins. These results are contradictory to the statements in the literature, that plasma gel formation occurs in Waldenström's disease.

Blood Proteins↗