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Biomedical subjects

H Bouissou

Publications and source records attributed to H Bouissou.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Resistance of the ocular conjunctival tissues to nalidixic acid in rabbits (author's transl)].

Microscopic examination of the articular cartilage of adult and young rabbits after daily intraperitoneal injections of 0.50 g/kg of nalidixic acid for four weeks demonstrated the presence of characteristic lesions due to nalidixic acid in the young animals only. No modification of the texture of the cornea or sclera was noted after microscopic examination of either young or adult animals, and no alterations were present in the juxtascleral cartilage.

Animals↗
PubMed1979

Fine structural evidence of increased endothelial permeability in chronic lathyrism.

The endothelium of the thoracic aorta of Wistar rats intoxicated with Beta-Aminopropionitrile (BAPN) for 9 weeks was studied. The animals were sacrificed at intervals, from the first to the 9th week of the treatment and 1, 2 and 3 months after the end of the treatment. Changes in the endothelial cells were studied by electron microscopy after staining with uranyl acetate and lead citrate, after impregnation with lanthanum. BAPN increased endothelial permeability, pinocytosis was more active in treated rats than controls, the intercellular junctions widened and cytoplasmic lesions with cell necrosis occurred. These intimal changes were comparable to those observed in man during ageing and in arteriosclerosis.

Animals↗
PubMed1979

Cutaneous cholesterol and plasma lipoproteins in young subjects.

The present report concerns the biochemical and anatomo-pathological study of the skin and the plasma lipoprotein fractions in a young population (average age : 22 +/- 1.5 years). The levels of cutaneous cholesterol and the ratio HDL cholesterol/total cholesterol are closely linked even through the histological structure of the skin is still normal; the level of cutaneous cholesterol giving a good indication of the degree of vascular ageing. The observations confirm the usefulness of measuring these two parameters in the detection of early atherosclerosis.

Adult↗
PubMed1978

Chronic lathyrism and atheromatosis in the rat. Study of the V.L.D.L. and plasma and arterial wall lipids.

Temporary chronic administration of Beta-amino-propionitrile (B.A.P.N.) produced morphological and biochemical changes of the aortic wall of rat as well as abnormalities of the plasma lipid levels. A hyperlipidic diet resulted in the blood plasma lipid abnormalities as B.A.P.N. intoxication. Nine weeks of B.A.P.N. followed by 42 weeks of a hyperlipidic diet increased the aortic cholesterol level and induced an atheroma. The diet alone produced only an endothelial lipid overload. The structure of arterial wall played the decisive role in atherogenesis.

Aminopropionitrile↗
PubMed1978

[Cartilaginous tissue and nalidixic acid].

1. Medication with nalidixic acid never produced articular lesions in adult animals. 2. In the species of immature animals, if sensitive to nalidixic acid, the articular lesions were macroscopically and microscopically identical. 3. The lesions regressed spontaneously as the basal germinative layer was never affected.

Age Factors↗
PubMed1978

Hypothesis on microangiopathy of cutaneous capillaries.

Microangiopathy is a more or less pronounced PAS deposit-located exterior to the endothelial cells of the lymphatics and the basal membrane of the capillaries. This lesion, found in various normal and pathological states, has generated numerous pathogenic hypotheses. The presence of microangiopathy in 5 groups of 50 subjects representing five different clinical conditions, subjects over 60 years old or less than 40, diabetics, latent diabetics or patients with severe coronary heart disease, together with microscopic and/or ultrastructural lesions of the connective tissue (fibroblasts, collagen and elastic fibers, ground substance) has enabled us to propose a pathogenic hypothesis applicable to any microangiopathy. The initial change, hereditary or acquired, would be fibroblastic or interstitial. It would be characterized by the accumulation of glycoproteins, proteoglyacans and soluble collagen in the interstitium. Incomplete drainage of these macromolecules would occur around the blood and lymphatic capillaries and manifest itself by a PAS deposit, the hallmark of the microangiopathy.

Adult↗
PubMed1978

Aortic lathyrism and atheroma in the rat by prolonged hyperlipidic diet.

Constant, deep, extensive aortic atheroma can be induced in rats that are athero-resistant. Two main factors are involved in this experimentation: (1) Parietal alteration following chronic experimentation with beta-aminopropionitrile (BAPN, 8 weeks) and a metabolic factor with hyperlipid diet. Electronmicroscopic examination has shown progressive lesions in the elastic framework and modifications of cells in the media with dedifferentiation into fibromyocytes and also multiply. The changes are responsible for hyperplasia of the intima as well as its thickening and collagenization. They support observations made in man during aortic aging. (2) A metabolic factor with hyperlipidic diet. This diet given at various times during intoxication causes lip deposition in the intima and substantial penetration into the media when the lesions are developing.

Aminopropionitrile↗
PubMed1977

[A symptomatic parathyroid adenoma. Value of parathyroid hormone determination through selective catheterization of the thyroid veins].

A parathyroid adenoma is reported in a girl aged 12 years in whom hypercalcaemia was discovered by chance. Investigation of calcium metabolism suggested the diagnosis of hyperparathyroidism and studies of the urinary cyclic AMP and determination of the plasma parathyroid hormone concentration further added to the evidence. The diagnosis of parathyroid adenoma was made after determination of the parathyroid hormone concentration at various sights during selective catheterization of the tyroid veins. This was confirmed at surgery. In this patient the place of catheterization of the inferior thyroid veins in the early diagnosis of primary hyperparathyroidism is discussed.

Adenoma↗
PubMed1977

[Chronic lathyrism. Protective effect of pyridinol carbamate on connective tissue lesions in the rat (author's transl)].

The use of lathyric toxins (BAPN) in low dosage (1 g/kg/day) for a period of 8 weeks caused in the rat simultaneous changes in the skin and aortic connective tissues. In the skin. collagen tissue was dislocated and broken in fragments, the elastic tissue disappeared, the fibroblasts were vacuolized and presented evidence of injury. These lesions were comparable to those observed in human skin during ageing. The addition of pyridinol carbamate (PDC) to BAPN prevents the formation of lesions of the elastic tissue and of fibroblasts. When given after the cessation of the lathyrogen treatment PDC arrested the formation of the lesions and accelerated their regression.

Aminopropionitrile↗