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Biomedical subjects

H Bleiberg

Publications and source records attributed to H Bleiberg.

At least 145 records · Page 8Linked to original sources
PubMedDate not supplied

Evaluation of clinical efficacy of new medical treatments in advanced colorectal cancer. Results of a workshop organized by the EORTC GITCCG. European Organization for Research and Treatment of Cancer. Gastrointestinal Tract Cancer Cooperative Group.

During the last few years several factors have contributed to an increasing change in the medical treatment of advanced colorectal cancer. Among them are the more general acceptance of the impact of chemotherapy on quality of life and survival in first as well as in second-line treatment, the introduction of new drugs and the definition of novel endpoints which can roughly be defined as "patient benefit". For this reason the European Organization for Research and Treatment of Cancer (EORTC) Gastrointestinal Tract Cancer Cooperative Group (GITCCG) felt it was appropriate to organize a workshop with experts from different countries and national groups to discuss in depth several aspects concerning the treatment of patients with advanced colorectal cancer.

Clinical Trials as Topic↗
PubMedDate not supplied

Oral fluoropyrimidines in colorectal cancer: a door open to the future?

Since its first use 40 years ago, 5-fluorouracil (5-FU) has become an unquestionable component of colorectal cancer treatment. It is also now well established that infusional 5-FU administration, in combination with leucovorin, is associated with better tolerance and at least equal efficacy than bolus administration. However, requiring catheter and infusion pumps, infusional 5-FU administration is costly, rather inconvenient for patients and potentially associated with morbidity, initiating subsequent oral chemotherapy development. To address intravenous 5-FU related issues, oral fluoropyrimidines have been developed such as capecitabine, preferentially converted to 5-FU into tumour cells, and UFT, able of bypassing intestinal dihydropyrimidine dehydrogenase. We discuss in this article current oral fluoropyrimidines achievements in colorectal cancer management.

Administration, Oral↗
PubMedDate not supplied

Treatment of advanced colorectal cancer.

Colorectal cancer is one of the most chemotherapy-resistant human malignancies. After 30 years of intensive research, 5-fluorouracil (5-FU) remains the most frequently used drug. The expected response rate is of about 15% without any proven benefit in survival. One of the combination most investigated recently has been methyl CCNU, 5-FU, vincristine and streptozotocine (MOF-S). It has shown a response rate of 30-40% but only little benefit in survival. Although cisplatin (CDDP) is inactive as a single agent, the combination of 5-FU and cisplatin (CDDP) might still be of interest when CDDP is fractionated over 3 to 5 days and 5-FU given as a continuous infusion. Local treatment using the intra-arterial and the intraportal route gives rather high response rates, but has not shown any benefit in survival. Biochemical modulation using allopurinol, methotrexate and leucovorin has raised considerable interest, but at the present time no major benefit in survival has been disclosed.

Allopurinol↗
PubMedDate not supplied

[Adjuvant treatment in cancer of the stomach].

Surgical excision remains up to now the first potentially curative treatment for patients who are suffering from stomach cancer. The encouraging results recently obtained in the survival of these patients are to be attributed essentially to the screening for this disease. Unfortunately, in the countries of the Western World, 80 to 90% of patients with a stomach cancer still consult their physician at an advanced stage of the disease. This makes it necessary to look for new efficient adjuvant treatments to be implemented after surgery. Numerous chemotherapeutic combinations have been studied. The FAM association is the best known among all these; results of these treatments are reviewed. Other encouraging perspectives come from the association of chemotherapy and biochemical modulators, chemotherapy and radiation-therapy, IORT and other adjuvant treatments. These results are also reviewed.

Antineoplastic Combined Chemotherapy Protocols↗