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Biomedical subjects

H Bleiberg

Publications and source records attributed to H Bleiberg.

At least 127 records · Page 7Linked to original sources
PubMed1982

Combination of dacarbazine and mitomycin in advanced colorectal cancer.

Twenty evaluable patients with advanced measurable colorectal cancer received 3-week courses of a combination of IV dacarbazine 300 mg/m2/day from day 1 to day 5 and IV mitomycin 2 mg/m2/day from day 1 to day 5. Fourteen of these patients had had no prior chemotherapy and received two or more courses of this two-drug regimen. None of the patients achieved complete or partial response. Severe to life-threatening myelosuppression, was encountered in patients with prior radiotherapy and or prior chemotherapy, and/or in patients with a Karnofsky score less than or equal to 70. Hematologic toxicity was mild in the other patients. Nonhematologic toxic effects were generally mild to moderate and consisted essentially in nausea and vomiting. It is concluded that in our hands the regimen selected for this trial has no significant antitumor activity in advanced colorectal cancer.

Adult↗
PubMed1982

Is lumbar epidural analgesia an alternative in patients who have incomplete colonoscopy with standard premedication?

Total colonoscopy is unsuccessful in about 10% of attempts. In three fourths of the cases, failure is due to the patient's inability to tolerate the procedure and difficulty in negotiating the sigmoid colon. Lumbar epidural analgesia has been used in a series of 29 patients referred for total colonoscopy which had been unsuccessful using intravenous analgesia. The cecum was reached in 27 of 29 examinations. Mean time required to perform total colonoscopy was 10 min and took less than 5 min in one third of the cases. Complete visceral analgesia was responsible for one case of perforation.

Adolescent↗
PubMed1982

Total parenteral nutrition-induced cholestasis mimicking large bile duct obstruction.

The authors present a case of cholestatic jaundice which developed during total parenteral nutrition. The histology of the liver mimicked the picture of large bile duct obstruction. However, there was no duct obstruction and the symptoms regressed after the caloric input was reduced. At postmortem examination, the portal inflammatory infiltrate had cleared and was replaced by fibrosis. Alterations in bile chemistry could be responsible for the similarity between the lesions induced by parenteral feeding and those classically described in large bile duct obstruction.

Biopsy↗
PubMed1980

Laparoscopy in the diagnosis of liver metastases in 80 cases of malignant melanoma.

80 patients with histologically proven malignant melanoma were submitted to laparoscopy. 44 had advanced disease and 36 were clinically locoregional (23 stage I, 13 stage IIb). Results of a liver scan and liver function tests were available before starting this procedure. In all cases, biopsies were obtained through the laparoscope using a Menghini liver biopsy needle, specimens, being taken under visual control from the macroscopically suspected area. If no lesions was seen, two needle biopsies were taken at random from the anterior and posterior areas of both lobes. The liver was invaded in 11% of the patients with advanced disease, and in 23% of those with stage IIb. All the positve laparscopies occurred with biochemistry and/or liver scan were also abnormal, and biopsies taken at random in normal-looking livers were all negatives. Benign tumors were found in 13% of the cases. Some of these were indistinguishable from metastatic melanoma on the basis of their maroscopic aspect alone.

Biopsy, Needle↗
PubMed1979

Endoscopic appearance of irradiated gastric mucosa.

Irradiation of the epigastric area for gastric cancer may induce actinic lesions of the stomach characterized on endoscopic examination by ulcerations, haemorrhagic gastritis, fragility of the mucosa, thickening and congestion of the gastric folds.

Gastric Mucosa↗
PubMed1978

The use of peritoneoscopy in the detection of liver metastases.

Peritoneoscopy was carried out in 352 cancer patients with clinical suspicion of liver involvement in most cases. Principally because of patient discomfort, adequate liver biopsy was obtained in only 66% of 240 patients who underwent peritoneoscopy under local anesthesia while, under general anesthesia, biopsies could be taken in 90% of 112 patients. When the liver was macroscopically free of disease, the yield of positive peritoneoscopy was minimal regardless of the number of blind deep biopsies. Peritoneoscopy provided histologic demonstration of hepatic invasion in a total of 55 patients. Seven false-negative examinations out of 19 negative peritoneoscopies (36%) were identified by subsequent laparotomy or autopsy within 2 months. These preliminary data, although difficult to interpret in terms of accuracy of the method, point to the possible contributions of peritoneoscopy in detecting liver metastases.

Biopsy, Needle↗
PubMed1977

Cell cycle parameters in human colon: comparison between primary and recurrent adenocarcinomas, benign polyps and adjacent unaffected mucosa.

The duration of S phase and the labeling index were measured in adenocarcinomas, in polyps and in adjacent unaffected mucosa of a same patient. The in vitro double labeling technique was employed. The S phase duration in tumors was significantly longer than in unaffected mucosa and polyps. This agrees with previously reported data on human skin, colon and rectum and supports the suggestion that a long S phase might correlated with carcinogenesis. The labeling index in the mucosa adjacent to the tumors is higher than previously measured in normal tissue. Following colectomy however, the labeling index in unaffected mucosa and tumor was lower than prior to surgery. This suggests the disappearance of a systemic factor (in the colon?) which positively regulates the proliferative activity in the rectal and colonic musoca. The maintainance of a lengthened S phase duration in the recurrent tumor where L.I. is lowered, indicates that the proliferation rate and the S phase duration are regulated by separate control factors.

Adenocarcinoma↗
PubMed1977

Peritoneoscopy as a diagnostic supplement to liver function tests and liver scan in patients with carcinoma.

Liver function tests, liver scintigraphy and peritoneoscopy were carried out in 240 patients with carcinoma. Hepatic invasion was demonstrated by peritoneoscopy essentially when both of the other tests were positive. However, in one-third of the patients, peritoneoscopy revealed the presence of other pathologic changes which could account for the positivity of either of the other diagnostic procedures. The status of the liver, with regard to presence or absence of metastases, could be microscopically documented in 59 patients. False-negative findings of liver chemistry tests, liver scan and peritoneoscopy were seen in 27, 42 and 36 per cent, respectively, of the patients while the rate of false-positive results was 15, 10 and 3 per cent, respectively. The rate of false-negative peritoneoscopy examinations in the absence of simultaneous positivey of the two other investigations was insignificant. These data indicate that liver chemistry tests, liver scan and peritoneoscopy play a major and complementary role in the screening of patients with carcinoma.

Biopsy↗
PubMed1976

Peritoneoscopic evaluation of the effect of chemotherapeutic agents on liver metastases of breast cancer (report of 2 cases).

Two cases of breast cancer are presented in which massive liver metastases were proved by biopsies prior to treatment. Use of alternate cyclical hormonal cytotoxic combination chemotherapy (EORTC Clinical Trial, protocol, no 10741/3) was followed by a dramatic disappearance of neoplastic tissue. Peritoneoscopy associated with needle biopsy proved extremely useful to provide objective evaluation of the response to chemotherapy.

Antineoplastic Agents↗
PubMed1976

In vitro autoradiographic determination of cell kinetic parameters in adenocarcinomas and adjacent healthy mucosa of the human colon and rectum.

Using in vitro double labeling with two different doses of [3H]thymidine, we measured the S-phase duration and the labeling index in biopsy samples taken from human rectal and colonic adenocarcinomas. Samples from the adjacent healthy mucosa, taken at the same time as the tumor samples, were simultaneously subjected to the same measurements. The mean labeling index in tumors was higher than in the normal mucosa (32.5 and 17.0%, respectively). The mean S-phase value was also longer than in the normal tissue (19.4 versus 11.2 hr). These observations are discussed with reference to similar observations made in tumors of the human epidermis, especially considering the possible relationship of an increased S-phase duration with carcinogenesis. While no definitive conclusions may be reached, it seems prudent to consider an S-phase duration that is longer than normal to be a justification for attentive follow-up of the patient.

Adenocarcinoma↗