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Biomedical subjects

H Bittard

Publications and source records attributed to H Bittard.

At least 55 records · Page 3Linked to original sources
PubMed1991

Alterations in polymeric immunoglobulin receptor expression and secretory component levels in bladder carcinoma.

To assess the capacity of transitional cells to synthesize the release polymeric immunoglobulin receptor (pIg-R) in bladder carcinoma, we studied the localization of pIg-R in normal and tumor tissues and measured the levels of secretory component (SC) either in the free form or bound to Ig (S-IgA, S-IgM) in the serum and urine of 56 patients with transitional-cell carcinoma (TCC) of the bladder. In the normal bladder mucosa, pIg-R was localized in the cytoplasm and plasma membranes of the superficial cells and on all epithelial cell membranes. In TCC cases, 65% of those studied expressed pIg-R. A marked heterogeneity in pIg-R staining was observed in some tumors. Although a better expression of pIg-R in tumors with a well-preserved epithelial architecture was observed, no correlation was found between pIg-R expression and the grade or stage of the tumors in the patients under study. Three groups were established: (1) in TCC with no complications, serum levels of free SC and S-IgA were significantly increased; (2) in TCC with urinary infections (UI), serum levels of free SC and S-IgA were significantly higher than control values but lay within the same range observed in TCC with no complications and rates of urinary excretion of SC were significantly higher than those in normal subjects; (3) in TCC without UI but with hepatic disorders [high gamma-glutamyl transferase (GGT) activity], there was a correlation between serum S-IgA levels and GGT activity (r = 0.5, P less than 0.005) and serum SC levels were significantly higher than those observed in the other groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Biomarkers, Tumor↗
PubMed1991

Decrease in renal vascular resistance in University of Wisconsin solution preserved kidney transplants.

Renal vascular resistance was compared in 2 groups of renal grafts: group 1-16 kidneys perfused with University of Wisconsin solution and group 2-16 kidneys perfused with Euro-Collins solution. Both groups had comparable donors and recipient criteria. Renal blood flow was measured by a miniaturized pulsed Doppler probe fixed on the graft renal artery. Renal vascular resistance was calculated either according to the formula: renal vascular resistance (mm. Hg/ml. per second) = systemic arterial pressure (P)/renal blood flow or through the renal vascular resistive index (RVRI): RVRI = systolic flow velocity - diastolic flow velocity/systolic flow velocity = (S-D)/S. Renal vascular resistance estimation seems to be more contributory than renal blood flow in assessment of renal graft reperfusion disorders. Our results show that University of Wisconsin solution seems to preserve intrarenal arterial caliber better with a decrease in intrarenal vascular resistance, thus, allowing for a higher arterial graft perfusion flow.

Adenosine↗
PubMed1990

[pTa bladder tumors. II--Is it possible to predict ulterior infiltration?].

Among 534 patients with pTa bladder cancers, followed between 1 month and 17 years, 12% presented progression of their tumor (greater than or equal to pT1). We found three factors which could predict their progression: grade greater than or equal to G2, Mitotic index greater than or equal to 10, and 2 "non infiltrative" recurrences before 30 months.

Aged↗
PubMed1990

[Evaluation of the results of the treatment of male urethral stricture with a follow-up of more than 5 years].

149 cases of urethral stricture were treated in the Urology Department from 1971 to 1984. All of these patients have therefore been treated with a minimal follow-up of 5 years. There were 87 cases of post-traumatic stricture, 53 of whom were lost to follow-up during the survey, 8 died and 26 patients were able to be reviewed. The remaining 62 cases consisted of post-infectious strictures, with 37 patients lost to follow-up during the survey, 1 patient who died and 24 patients who were reviewed. The patients reviewed were assessed according to the criteria of the SFU (French Urology Society) survey. Direct vision internal urethrotomy was performed in 33 cases with 18 very good or good results (54%), segmental resection was performed in 10 cases with 7 very good or good results, urethroplasty was performed in 4 cases with 2 good results and 2 urethral dilatations were performed with 2 good results. The failures were essentially treated by more complex surgery (urethroplasty).

Bacterial Infections↗
PubMed1988

[Preliminary results of prophylactic adjuvant chemotherapy with CISCA in bladder tumors].

Over a period of 7 years, 14 patients with cancer of the bladder received postoperative curative adjunct chemotherapy with the CISCA protocol. Follow-up ranges from 5 to 84 months. Eleven patients had complete remission, 1 had a recurrence and 2 died. The results encourage us to administer systemic adjunct chemotherapy, whenever there are histologically-proven neoplastic emboli to the lymphatics.

Aged↗
PubMed1988

[Advantages of multifactorial analysis of correlations (Benzekri's method) in practice and in clinical research. A simplified example of its application to bladder tumors].

New methodology for the study of treatments of bladder tumors: Multifactorial correlation study according to Benzekri's method. Bladder tumors are characterized by a varying potential for progression which cannot be predicted and which is not taken into consideration in the traditional classification and in the studies concerning efficacy of treatments. The authors propose the attribution of a malignancy coefficient to each bladder tumor. This coefficient is calculated by means of a mathematical method based on statistical correlations (Benzekri method) between 10 prognostic factors, defined prior to any treatment. This coefficient is invariable for each tumor and its correlation with the survival curves has demonstrated its reliability. On the basis of this method, the authors have classified 539 bladder tumors (superficial or invasive) into groups according to their malignancy coefficient. In this way, the ideal treatment for each group can be proposed.

Humans↗