Effects of pentachlorophenol on hepatic drug-metabolizing enzymes and porphyria related to contamination with chlorinated dibenzo-p-dioxins and dibenzofurans.
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Biomedical subjects
Publications and source records attributed to H Bergman.
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The effect of alcohol intake on readaptation time (RAT) after photo stress is studied. Ten healthy subjects were given 0.72 g alcohol per kg body weight to be consumed within 20 min. The tests were made during a total period of 11-12 h. The findings demonstrate that moderate blood alcohol concentrations induce definite changes in RAT. An average RAT-prolongation of 60-70% was seen during the acute phase of intoxication. RAT-prolongation ended before the blood alcohol concentration had reached zero, but did not have the same downward slope. Following a period of reduction, a new prolongation of RAT was observed. The lack of congruence between the RAT-curve and the blood alcohol curve in the acute phase of intoxication and the post-alcohol increase are discussed. It is concluded that the alcohol-induced RAT-changes probably are CNS-effects and that the equipment used constitutes a sensitive method of estimating these effects.
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Optokinetic nystagmus (OKN) is used to study the eye's ReAdaptation Time (RAT) after a brief exposure to a light flash. The effects on RAT of breathing different concentrations of O2 are examined. Significant changes in RAT have been registered, showing that inhalation of 100% O2 as compared with room air, results in a shortened RAT (i.e. improvement), while inhalation of 9% O2 leads to an increased RAT (i.e. impairment). The physiology of RAT and the possible mechanisms behind the changes caused by different O2 concentrations are discussed. The findings of this group are compared with those of other studies.
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20 male, alcohol-discordant twin pairs, aged 45 to 65 yr. were compared for field-dependent cognitive style and general intelligence by means of one-sample t and multivariate Td2-tests. The high alcohol group was more field-dependent (p less than .01) than the low alcohol group, mainly because of poorer scores on the Embedded-figures Test. When general intelligence was controlled for, the amount of embedded-figures variance accounted for by consumption of alcohol dropped considerably.
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