[Detection and treatment of xerostomy].
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Biomedical subjects
Publications and source records attributed to H Ben-Aryeh.
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Seventy-one patients complaining of mouth dryness were examined. Decreased salivary rate of flow was found in fifty-six. Twenty-two patients did not respond to stimulation and were treated with artificial saliva. The thirty-four responding patients were treated with a mouthwash containing citric acid (Saliram). Of the patients using Saliram, 91 percent were satisfied with the results, and in 16 percent of these an increase in salivation was observed and persisted after treatment was discontinued.
The flow rate and composition of whole unstimulated saliva were measured in fifteen healthy controls and in forty-eight xerostomic patients, fourteen suffering from xerostomia per se, twenty-two from xerostomia with keratoconjunctivitis sicca (KCS), and twelve from xerostomia, KCS, and rheumatoid arthritis. A significant lower salivary flow rate was found in all the xerostomic patients. Sodium, potassium, and IgA concentrations were significantly elevated in the KCS and in the RA + KCS group in comparison with the patients who had xerostomia per se and with the healthy controls. Sialochemistry is thus recommended for the diagnosis of Sjögren's syndrome in xerostomic patients.
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Salivary and serum lithium concentrations were measured simultaneously in 118 manic-depressive patients. Lithium concentration in saliva was 2.24 +/- 0.35 times higher than in serum. An equation to calculate serum lithium concentration from salivary measurements was derived: Li serum = 0.36 Li saliva + 0.13. Psychotropic drugs had no effect on the salivary:serum ratio. Eighteen patients were followed for several weeks. A significant correlation coefficient between salivary and serum lithium concentrations was found in thirteen of the eighteen patients studied.
The presence of Candida in the oral cavity of denture wearers was compared to a control group. A significantly higher percentage (88%) of Candida "carriers" was found among the denture wearers in comparison to the control group (52%). No difference between the sialochemistry of denture wearers and controls was found in oral Candida "carrier".
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Sialochemistry was undertaken to detect subclinical involvement of salivary glands in patients with rheumatoid arthritis (RA). The concentrations of salivary sodium and IgA were significantly elevated in 24 percent of the RA patients. Eighty per cent of the patients with elevated sodium and IgA concentrations had keratoconjunctivitis sicca as well. No correlation between serum and salivary IgA levels was found. The results indicate that salivary sodium and IgA levels can be used for detection of subclinical salivary gland involvement and for follow-up of RA patients.
Sialochemistry was used to detect salivary gland involvement in KCS patients. Significantly elevated IgA was found in 52% of the patients, potassium in 48% and sodium in 32%. No correlation between the grade of Schirmer's test and the extent of changes in salivary composition was observed. The results indicate that salivary IgA, K and Na concentrations can be used for detection of salivary gland involvement of KCS patients.
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Eighteen leukemic patients were examined for the presence of Candida albicans in the oral cavity. Fifteen patients were found to be Candida "carriers." Nine of the patients were put on a chlorhexidine mouth rinse regimen. Although chlorhexidine was clearly fungicidal in vitro, no decrease in Candida titer was obtained with the mouth rinse. The ineffectiveness of the drug in vivo might be due to the specific location of Candida organisms in the oral mucosa.
One-hundred and twenty persons were screened for the presence of Candida in the mouth. Salivary samples were cultured on Sabouraud's agar, on yeast extract, and on Microstix. Microstix is a new and simple method testing for Candida. The reliability of the strip for detecting clinically identified candidiasis in severely ill patients was 100 per cent. Of ninety-three clinically healthy controls, forty-five were found to be Candida carriers according to the two conventional methods (Sabouraud's agar and yeast extract), but only forty-one of them by the strip. The discrepancy might be explained by the limit of the sensitivity of the strip (5.10(2) yeast per milliliter). The strip is recommended for testing clinically suspected candidiasis and is very useful for screening.
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