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Biomedical subjects

H Ben-Aryeh

Publications and source records attributed to H Ben-Aryeh.

At least 37 records · Page 2Linked to original sources
PubMed1987

Chemical analysis of whole saliva in Sjögren's syndrome.

In some studies, but not in all, abnormally high concentrations of salivary Na+, K+, and IgA have been found in patients with Sjögren's syndrome (SS). The lack of agreement between various reports might be due to the different ways in which saliva was collected. Some analysed stimulated parotid or whole saliva, whereas others used unstimulated saliva. In this study, therefore, the rate of flow and Na+, K+, and IgA levels in unstimulated and stimulated whole saliva in normals and in rheumatoids with and without SS have been determined. The results confirmed significantly raised levels of Na+, K+, and IgA in unstimulated whole saliva in SS. In response to stimulation there was marked decrease in Na+, K+, and IgA levels, whereas normally, as shown by the other two groups, there is an increase in Na+, no change in K+, and a mild decrease in IgA. As a result, the differences between SS and normals became much less significant (K+, IgA) or were even completely obliterated (Na+). The abnormal response of SS to stimulation may be partially explained by the initially low rate of flow and by the extremely high IgA levels. Thus chemical analysis of unstimulated whole saliva is much more sensitive than analysis of stimulated whole saliva in the detection of salivary gland involvement in SS.

Citrates↗
PubMed1986

Oral side effects of head and neck irradiation: correlation between clinical manifestations and laboratory data.

Salivary flow rate and composition, oral microflora and clinical manifestations of radiation damage were studied in 32 patients treated with external irradiation to head and neck areas. Several parameters were investigated: field arrangement, amount of salivary glands irradiated, clinical manifestations such as dryness of the mouth, taste impairment, dysphagia, salivary secretion and composition, and oral yeast flora. The salivary glands have a greater sensitivity to radiation damage than the gustatory tissues. The decrease in salivary secretion is accompanied by a rise in salivary sodium concentration, and in oral yeast flora. The clinical symptomatology was correlated with the amount of salivary glands irradiated. We found that most of the parotids have to be outside of the treated volume, when the rest of the major salivary glands are irradiated, to prevent severe dryness phenomena.

Candidiasis, Oral↗
PubMed1986

The salivary flow rate and composition of whole and parotid resting and stimulated saliva in young and old healthy subjects.

Resting and stimulated whole and parotid salivary composition and flow rate were examined in 63 healthy volunteers. No significant differences were found between the young and old in secretion rates and salivary concentrations of sodium, potassium, calcium, magnesium, and total protein. The activity of amylase in the resting and stimulated parotid saliva was significantly lower in the old.

Adult↗
PubMed1985

Effect of transdermal scopolamine on salivation.

The effect of transdermal scopolamine on salivary flow and composition was analyzed in 21 healthy volunteers. The flow rate of whole saliva was significantly lowered by transdermal scopolamine. Significant positive correlations were found between the placebo rate of flow and both the quantity and percentage decreases in response to transdermal scopolamine. The magnesium concentration was significantly increased during transdermal scopolamine administration, whereas the sodium, potassium, and calcium concentrations were not consistently altered. Accordingly, the magnesium secretion rate was unaltered, whereas sodium, potassium, and calcium secretion rates were significantly lowered by transdermal scopolamine administration.

Administration, Topical↗
PubMed1985

Occlusal adjustment by photocclusion.

The use of photocclusion to evaluate the results of occlusal adjustment before, during, and after treatment is described. The authors recommend the use of photocclusion to aid in evaluating occlusal adjustment performed with articulating paper.

Adolescent↗
PubMed1985

Do cyclic AMP concentrations in saliva reflect PTH biologic activity?

The aim of this study was to investigate whether the concentration of cAMP in saliva might reflect the biologic activity of parathyroid hormone (PTH), as nephrogenous levels of cAMP reflect parathyroid function. Patients with primary hyperparathyroidism (HPT) with elevated levels of PTH, nephrogenous cAMP, and serum calcium were found to have cAMP levels not significantly different from control subjects. When the levels of these parameters were reduced following parathyroidectomy, salivary cAMP concentrations were not affected. Similarly, an oral calcium loading test (which decreased both PTH and nephrogenous cAMP in normal subjects) failed to influence salivary cAMP levels. Basal salivary cAMP concentrations were low in secondary hyperparathyroid patients due to chronic renal failure and rose almost fivefold following dialysis despite the stable plasma cAMP levels and salivary flow rate. We conclude that salivary cAMP concentrations do not appear to be influenced by changes in circulating biologically active PTH. However, salivary cAMP concentrations do change in response to certain perturbations; this suggests that they are regulated by some other modulator(s).

Adolescent↗
PubMed1984

Composition of whole unstimulated saliva of human infants.

Whole unstimulated saliva of 168 infants aged 3 days to 12 months was analysed. The concentration of Ca, Mg and Cl was higher in the saliva of infants than in adults. The concentration of phosphate, IgA, amylase and pH was lower in infants; Na, K and total protein did not differ significantly. A wide range of all the concentrations was observed in the saliva of infants. No significant difference was found between the salivary composition of male versus female or of breast-fed as compared to bottle-fed infants. No difference before and after eruption of teeth was detected. Significant differences between different age groups were observed in the concentrations of Na, K, Cl, phosphate, protein, amylase and pH. No significant differences were found in Ca, Mg and IgA concentrations within the first year. A negative correlation between the age of the infants and the concentrations of Na, K, Cl and total protein was observed. A positive correlation was found for phosphate and amylase as a function of age.

Adult↗
PubMed1984

Salivary and lacrimal secretions in patients on lithium therapy.

Salivary and lacrimal secretion rates and salivary composition were examined in 22 manic-depressive patients on lithium therapy and in 21 matched, healthy controls. Serum immunoglobulins (IgG and IgA) were measured in these patients. Their oral health was examined and found to be unimpaired. Significantly lowered tear secretion was detected in the patients, while their salivary secretion rates were normal. The salivary concentrations of NA, K and IgA were significantly elevated in whole saliva. In parotid saliva, the concentrations of K and IgA were elevated, while Na was in the normal range. A significant correlation between serum and salivary lithium concentrations was found, indicating the usefulness of salivary measurements for monitoring. Informed consent of the patients was obtained after the nature of the procedures had been fully explained.

Adult↗
PubMed1984

Oral Candida in children.

One hundred forty healthy children, 3 to 12 years of age, were examined for the presence of oral Candida. Forty-five percent of the 3 to 5 1/2-year olds and 65% of the 6- to 12-year olds were found to be Candida "carriers" (p less than 0.05). No significant sex difference was found in the incidence of Candida "carriers." The salivary IgA concentration did not differ significantly in Candida "carriers" and noncarriers. A significantly higher IgA concentration was found in children 6 to 12 years old (0.02 less than p less than 0.05). The concentration of salivary electrolytes was similar in Candida-positive and Candida-negative children.

Age Factors↗
PubMed1984

Whole-saliva secretion rates in old and young healthy subjects.

Resting and stimulated whole-saliva secretion rates were compared in old and young healthy volunteers. The stimulated secretion rate was similar in both age groups, while the resting flow rate was significantly lower in the old females and males as compared with rates in the young.

Adult↗
PubMed1984

Saliva for monitoring of patients with primary affective disorders.

The salivary composition and flow rate of 78 patients with primary affective disorders and of 49 healthy volunteers were examined. The former were divided into two groups: Group 1--57 patients receiving lithium carbonate and psychoactive drugs, and Group 2--21 patients receiving psychoactive drugs only. A significant correlation between salivary and serum lithium was found in patients on chronic lithium therapy. Significantly reduced salivary flow rates and elevated potassium, calcium, magnesium and IgA concentrations were found in all the patients as compared with those of the healthy volunteers. Salivary sodium concentrations were significantly elevated in patients on lithium carbonate as compared with the levels in patients on psychoactive drugs only. These results indicate that changes in salivary gland function may occur in patients with primary affective disorders and in those receiving drug treatment. The use of saliva analysis for monitoring lithium dosage is recommended.

Female↗
PubMed1983

Salivary IgA in Sjögren patients.

Salivary flow-rate, Na, K and IgA were measured in 12 KCS patients for diagnosis of Sjögren's syndrome. 8 had elevated salivary IgA concentrations. The IgA was analysed on anti-IgA plates and on anti-secretory IgA plates. The results indicate that the elevation in salivary IgA in Sjögren patients is due to secretory IgA.

Female↗