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Biomedical subjects

H Becker

Publications and source records attributed to H Becker.

At least 505 records · Page 28Linked to original sources
PubMed1982

[A new microglossary for biopsy pathology].

The documentation of surgical biopsy reports involves the ordering, processing and retrieval of their informative content. Large amounts of data require computerization, which in turn demands a hierarchical code for optimal exploitation. The best coded nomenclature at present is the Systematized Nomenclature of Medicine (SNOMED), which was developed from the Systematized Nomenclature of Pathology (1965) after a 10-year trial and systematic evaluation. This system is based on the principle of facet classification and was conceived especially for computerized data processing. A microglossary is a strict subset of diagnostic terms for one particular field, which has been chosen from the entire set of medical terms available. The microglossary for computerized processing of biopsy data, which is currently being developed at the Department of Pathology of Graz University, is presented in this paper.

Austria↗
PubMed1982

[Fetal alcohol syndrome and malignant tumors].

This paper presents the case report of a 2 year-old boy in whom a grade II fetal alcohol syndrome was diagnosed at 17 months. At 21 months, an embryonal rhabdomyosarcoma of the urinary bladder trigone was found, and the tumour excised. Polychemotherapy was initiated, but bone-marrow depression and death in septicaemic shock followed. The main autopsy findings included the demonstration of tumour remnants in the urinary bladder and prostate, and a severe acute purulent pyelonephritis. This is the fifth case of fetal alcohol syndrome in conjunction with a malignant tumour to be reported in the international literature. These cases do not show any uniformity as to tumour type. No conclusion can as yet be drawn as to whether there is a pathogenetic connection between the fetal alcohol syndrome and the occurrence of malignant tumours (as is the case with the fetal hydantoin syndrome and neuroblastoma), or whether these findings are purely coincidental. Clinicians and pathologists should, however, be advised to look more closely for even minimally pronounced forms of the fetal alcohol syndrome in children with embryonic tumours.

Female↗
PubMed1982

[Hereditary quivering of the chin in a West Spanish family].

An unusual hereditary tremor which affects only the m. mentalis is reported. In four generations of a West Spanish family 20 members exhibited the symptom. It presents a quick rhythmic contractions of the m. mentalis with a frequency of 6-11/s. The amplitude varies greatly. The trembling of the chin appears at intervals from birth and may last seconds or minutes with shorter or longer asymptomatic periods. Stress or excitement can cause or intensify the symptoms. The quivering of the chin found in this West Spanish family does not differ from that described in 11 other families reported in the literature. They are all clinically identical with each other, and in the 12 families the symptom follows an autosomal dominant mode of inheritance. The penetrance is slightly reduced, and both sexes are equally affected. It is not serious, but for the patients it is a rather tedious anomaly which is hardly ever reported to a physician.

Adult↗
PubMed1982

[Anterior resection of the rectum: comparison of the conservative suture technique and machine anastomosis (author's transl)].

Of a total of 3850 operations on the colon and rectum (1964--1980) 52 hand-made anastomoses after anterior rectum resection were performed from September 1979 to August 1980 (resection quota 47%) without intestinal fistula. These were compared with 52 anastomoses by machine (EEA). There was no extension of surgical indication by use of the machine. Complications like anastomotic insufficiency occurred in a similar range (hand: 4, machine: 3), but were easier to manage after machine suture. The number of other complications was comparable. Use of the machine gives advantages to the experienced surgeon, but it should only be used by those who are able to master the complex technique.

Aged↗
PubMed1982

Luteal phase following oocyte aspiration, in vitro fertilization, and embryo transfer in clomid/HCG-stimulated cycles.

Using basal body temperature and repeated radioimmunological plasma progesterone estimations we monitored the luteal phase in seven patients after the administration of Clomid/hCG, oocyte recovery, in vitro fertilization and embryo transfer. In six of these women, the transferred embryos did not implant, and they bled 13--16 days after oocyte recovery. Neither the basal body temperature charts nor the plasma progesterone levels provided any indication of a luteal phase defect, being indistinguishable from those obtained in a control group of healthy women during the natural cycle. In the seventh woman, transfer of an eight-cell stage embryo resulted in implantation and a pregnancy which, to date (37th week) is developing normally.

Body Temperature↗
PubMed1982

Comparison of steroid concentrations in venous and arterial blood across the human testis. Unconjugated 5 alpha-androstane-3 beta, 17 beta-diol: an important androgen metabolite of the human testicular-epididymal unit.

By means of specific radioimmunoassays unconjugated testosterone, 5 alpha-dihydrotestosterone, 5 alpha-androstane-3 alpha, 17 beta-diol, 5 alpha-androstane-3 beta, 17 beta-diol and estradiol-17 beta as well as testosterone-glucosiduronate were estimated in the plasma of the spermatic vein and artery simultaneously with the determination in peripheral venous and arterial plasma in ten male patients undergoing orchiectomy for prostatic cancer. The following results were obtained: A positive concentration gradient was found for all steroids. The testicular "secretion" of 5 alpha-androstane-3 beta, 17 beta-diol was established for the first time. The venous-arterial transfer of the mentioned steroids within the plexus pampiniformis yielded the following figures: 5.1%; 17.4%; 6.5%; 5.4% 5.1% and 6.5%, respectively. The testicular and/or epididymal origin of the different steroids was calculated to be of the following order of magnitude (mean values): Dihydrotestosterone 28%, 5 alpha-androstane-3 alpha, 17 beta-diol 45%, 5 alpha-androstane-3 beta, 17 beta-diol about 100% estradiol-17 beta 63% and testosterone-glucosiduronate 3%.

Aged↗
PubMed1982

Left ventricular O2 requirements of pressure and volume loading in the normal canine heart and inaccuracy of pressure-derived indices of O2 demand.

The purpose of this study was to: 1) re-evaluate the left ventricular O2 requirements (MVO2) of pressure and volume-loading; and b) assess the accuracy of pressure-derived indices of left ventricular (LV) O2 demand under pressure-loading and volume-loading conditions. Using a right heart bypass preparation (heart rate 150 beats . min-1), mean arterial pressure (7.3 to 22.9 kPa) and cardiac output (0.8 to 6.0 litre . min-1) were varied independently. Adequate left ventricular O2 supply was demonstrated by normal transmural distribution of blood flow, normal myocardial lactate metabolism, and intact reactive hyperaemic responses. For equivalent increases in cardiac external work (from 2 to 4 joules . min-1) pressure-loading and volume-loading resulted in similar increases in O2 uptake (59% and 49%, respectively, P = 0.21). MVO2 was consistently greater for volume-loading than for pressure-loading at any SPTI, pressure-rate product, and triple product. The prediction of O2 demands by these indices under these loading conditions collectively was unreliable (r = 30 to 0.42). O2 requirements of the left ventricle with both pressure-loading and volume-loading were highly correlated (r = 0.82 to 0.99) with meridional wall stress. We conclude that: 1) volume-loading conditions have a greater O2 requirement than appreciated previously; 2) pressure loads and volume loads require similar O2 uptake in the normal canine heart for similar external work; 3) currently used pressure-derived indices are unreliable predictors of LV O2 demand when loading conditions are varied; and 4) O2 requirements are more uniformly related to meridional wall stress.

Animals↗
PubMed1982

Correlation of pancreatic blood flow and high-energy phosphates during experimental pancreatitis.

A dog model was used to measure the hemodynamic changes occurring during acute pancreatitis induced by intraductal injection of fresh trypsin-bile-blood mixture. Pancreatic blood flow was measured with 15-micrometer radioactive microspheres. Measurements of pancreatic adenosine triphosphate (ATP) and creatine phosphate (CP) were made under normal conditions and during acute hemorrhagic pancreatitis. Basal ATP and CP concentrations were 5.82 +/- 0.25 and 5.30 +/- 0.31 mmol/g wet tissue, respectively. Hemorrhagic pancreatitis was characterized by a severe reduction in pancreatic blood flow, followed by a 45% fall of ATP and a 70% lowering of CP. These results suggest that inadequate pancreatic tissue perfusion during acute pancreatitis results in a marked depletion of high-energy phosphate stores. We suspect this energy depletion reflects the progression of the disease from edematous to hemorrhagic pancreatitis and causes irreversible damage of pancreatic tissue.

Acute Disease↗
PubMed1982

Endogenous androgen levels in epithelium and stroma of human benign prostatic hyperplasia and normal prostate.

5 alpha-Dihydrotestosterone (DHT) and 5 alpha-androstane-3 alpha, 18 beta-diol (3 alpha-diol) were extracted from epithelium and stroma of human benign prostatic hyperplasia (BPH) and of normal prostate and quantified by RIA. The main results were: (1) concerning the BPH, DHT is mainly located in the nuclear fraction of epithelium and stroma, whereas 3 alpha-diol was completely of extranuclear origin, (2) in the nuclei derived from BPH stroma the DHT content (7.1 +/- 0.88 pmol/mg DNA, mean +/- SEM [n = 14]) was significantly higher (P less than 0.01) than in the nuclei derived from BPH epithelium (3.8 +/- 0.38 pmol/mg DNA [n = 14]). The DHT content in the nuclear fraction derived from unseparated, i.e. whole tissue, was 5.6 +/- 0.60 pmol/mg DNA [n =14], (3) the biological significance of the overwhelming DHT accumulation in the stromal nuclei for the BPH tissue is reflected by a significant correlation between the DHT values in the nuclei from stroma and whole tissue (rs = 0.710, P less than 0.01) and (4) in four normal prostates the DHT content in the nuclear fraction of epithelium (1.3 +/- 0.37 pmol/mg DNA) and stroma (2.2 +/- 0.93 pmol/mg DNA) was significantly lower (P less than 0.01, each) compared with the respective BPH fraction. These data support earlier findings which indicate that the stroma of BPH is a preferential tissue for androgen metabolism.

Adult↗