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Biomedical subjects

H Barz

Publications and source records attributed to H Barz.

31 records · Page 2Linked to original sources
PubMed1979

Image processing in pathology. IX. A new morphometry system and its application on gangliocytes of the nucleus olivaris.

This paper describes a new software system for automatic image processing in pathology. The system is based on the hardware NU2/ODD/PDP8 and the thereby yielded results. The effectiveness of the system esp. its velocity has been essentially improved by a significant modification of the primary data sampling and by the new implementation of feature determination. The first application of this new system concerns age-dependent alterations of the gangliocytes in the nucleus olivaris.

Adolescent↗
PubMed1978

Image processing in pathology. V. Interpretation of feature distributions of liver cell nuclei in histological sections.

A new method is applied for calculating the volume and extinction of liver cell nuclei from area and extinction of their sections in histological slices. With a special classificator for the automatical processing of microscopical pictures 96 per cent of morphologically controlled aequatorial sections of liver cell nuclei are correctly recognized. Using a mathematical model (additive fitting of three normal distributions to the given feature distribution) ploidie classes and volume classes can be recorded more exactly.

Cell Nucleus↗
PubMed1977

[Image processing in pathology. III. Structure and use of an automatic morphometry system for recording morphometric features of nuclei (author's transl)].

UNLABELLED: An image processing system for morphological investigation of liver cell nuclei in biopsy specimens is demonstrated. The present study deals with the age dependence of normal hepatic nuclear areas. The results were compared with those of conventional methods. MATERIAL AND METHODS: The image processing system consists of a microscope, an image dissector and a computer (central processing unit, display, teletype, magnetic tape devices and line printer). 74 liver biopsies were investigated. They sshowed no signs of acute or chronic diseases. Paraffin sections of 4 micron in thickness were prepared and stained by Feulgen method. 8-10 biopsies were available for each decade from 1-8. 18,000 liver cell nuclei from all specimens were isolated and measured automatically. Using the image processing system and adequate computer programs 20 parameters of all isolated nuclei were gained (parameters of shape, size and structure of the nuclei). For sampling and processing of the information the following programs are developed: PROBE Program for investigation of optimal parameters of scanning and processing. SAMPL Program for scanning, object isolation, feature extraction and storage of data records. KORRL Program for investigation of correlations between the features of objects. LISTE Program for listing of data records. ULTRA Program for search of objects with extremal features. CODER Program for correction od data records. ADAPT Program for training of classificators. SCHAU Program for demonstration and checking of the classificator. MORPH Program for output of feature distributions and statistical parameters. Following object features were calculated and investigated: features of size: KOFL area within the object contour; KKFL minimal covex area of the object; ZKFL object area without holes; KONL length of the object contour.

Adolescent↗
PubMed1977

[The prevalence of single and synchronous multiple tumours in autopsy series and its dependence on age (author's transl)].

The present study reports the age specific prevalence rate of tumors in autopsies of the years 1958--1969, registered in the Medical Academy "Carl Gustav Carus" Dresden. The results refer to the total of all malignant tumors, to several tumor sites as well as to multiple simultaneous tumors. In many neoplasms highest prevalence occurs in presenile age (malignancies of lung, uterus, ovar, brain, and bone marrow). On the other side prevalence of carcinoma of breast, urinary bladder, kidney, prostate, and large intestine increases up to the oldest age-groups. With respect to the population the prevalence of cancer increases permanently up to the age of eighty and decreases only in the following age-groups. The age-specific prevalence of simultaneous multiple tumors referred to cases of single tumors in the post-mortem findings reveals an analogous age distribution curve. The prevalence of simultaneous cancer is discussed concerning the influence of age and duration of the malignancy.

Adolescent↗
PubMed1976

[Amyotrophic lateral sclerosis with myoclonic bodies (Lafora bodies) (author's transl)].

In the present investigation 2 sporadic cases of amyotrophic lateral sclerosis with the occurrence of myoclonic bodies (Lafora bodies) in the CNS are reported. The patients died after about 14 respectively 8 months lasting disease at the age of 41 and 43, respectively under the clinical signs of an ALS. Morphology, staining qualities, and the distribution of the myoclonic bodies in our cases correspond to the adult form of the myoclonic body disease (type Lundborg). In the literature we found further 6 cases of neurogenic muscle atrophy with the occurrence of myoclonic bodies in the CNS so that one might suppose a syntropy of these two affections. The possible pathophysiological relations of neurogenic muscle atrophy to the occurrence of myoclonic body disease in adults are briefly discussed.

Adult↗
PubMed1975

[Liver-damaging action of halothane--an animal experiment study].

After long-term exhibition to halothane (up to 96 hours), centrolobular hepatic damage (fatty degeneration, necrobiosis and necrosis) developed in rats, proportionally to the number of anesthesias and shortening of the intervals. From these results no hepatotoxic effect of halothane can be derived, since the alterations might be caused by hypoxia alone.

Animals↗
PubMed1975

[Pathological findings in subacute necrotizing encephalomyelopathy (Leigh's disease) (author's transl)].

About 8-years old boy with a brief clinical history and postmortem findings of a subactue encephalomyelopathy (Leigh-Syndrom) is reported. Pathohistological features were found to be of microcyst formation, vascular proliferation, proliferation of astrocytes, fibrillary gliosis, partial destruction of the myelin sheaths, relative preservation of the cell bodies of neurons. The lesions were symmetrical and involved the tegmentum mesencephali, the lamine quadrigemina, the substantia nigra, the tegmentum pontis, the tegmentum of the medulla oblongata, the basal protion of nucl. lentiformis, the ansa lenticularis, the thalamus, the hypothalamus and the gray matter of the spinal cord. Moderate changes were in the cerebellum. There was no marked histological changes in the cerebral cortex and white matter of the cerebrum, the mammillary bodies, the nervi and tracti optici and the peripheral nerves.

Autopsy↗
PubMedDate not supplied

[Symptomatic Langerhans-cell-histiocytosis of the cervical spine in a child: case report].

We report on a six year old female presented with a painful torticollis and a hemidysaesthesia caused by destruction of the third cervical vertebra and a paravertebral soft-tissue mass. At diagnostic routine finally a biopsy gives the diagnosis of Langerhans cell histiocytosis. In a second open approach the destructed vertebral body was replaced by a precisely adjusted autologous bone interponate and the patient was maintained in halo vest immobilisation. The outcome is described and an overview of the current literature is given.

Biopsy↗
PubMedDate not supplied

[Image processing in pathology. IV. Age dependent changes of morphometric features of liver cell nuclei in biopsies].

PROBLEM: Several authors reported age dependent changes of single morphometric parameters on liver cell nuclei. In this study a recently developed automatic morphometry system was applied to recording of many liver cell nuclei parameters in histologic sections of liver biopsies simultaneously. The relations of the automatically generated parameters according to the age of the individuals are to be demonstrated.

Adolescent↗