The effect of transfusions and donor pretreatment on canine renal allograft survival.
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Biomedical subjects
Publications and source records attributed to H B Slot.
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A series of 305 normal subjects and 77 patients with angiographically proven stenotic or occlusive arterial disease of the lower limbs was studied with Doppler ultrasound pressure measurements and strain gauge plethysmographic arterial flow measurements. The 2 techniques were compared singly and in combination at rest and after exercise or reactive hyperemia. Pressure-flow patterns were found to correlate well with the segment(s) and extent of involvement with arterial disease, especially in patients with superficial femoral artery disease. However, it was found that calf blood flow measurements were of little assistance in predicting the level and severity of involvement over and above the information obtained by pressure measurements alone.
Arteriography is regarded as the objective method for evaluation of arterial disease and is commonly used as the reference for the assessment of the accuracy of noninvasive diagnostic methods. Because no data are available supporting its reliability, a study regarding the interobserver variability of single-plane arteriography was done. Twenty-one translumbar aortograms were read by 11 surgeons and radiologists, and the results were analyzed with a statistical method which takes into account agreement by chance. It was found that interobserver agreement concerning the profunda bifurcation was only marginally more than that provided by chance. Occlusions were well recognized by the 11 observers, but the interobserver agreement on the degree of arterial stenosis was poor.
Protracted administration of oral anticoagulant agents to patients presenting symptoms of peripheral arteriosclerosis is a treatment in widespread use in the Netherlands a Germany. However, a critical perusal of the available literature reveals a scarcity of objective data which might confirm the value of this treatment. It may be concluded from the data in the literature that protracted administration of anticoagulants may be useful only in case of stenosis of the superficial femoral artery. It is pointed out that a statistically correct study of this subject, with use of objective parameters, is urgently necessary.