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Biomedical subjects

H Adriaensen

Publications and source records attributed to H Adriaensen.

At least 55 records · Page 3Linked to original sources
PubMed1985

A long-term open, clinical and pharmacokinetic assessment of sublingual buprenorphine in patients suffering from chronic pain.

Buprenorphine was administered as sublingual tablets to 70 patients suffering from chronic pain of malignant or non-malignant origin. Daily doses ranging from 0.4 mg to 3.2 mg were administered and good analgesia was reported by the majority of patients. The most common unwanted effects were drowsiness/sleepiness, nausea and/or vomiting and sweating which appeared to be dose related but the incidence of dizziness was not related to daily dose. The incidence of all these unwanted effects except drowsiness/sleepiness decreased after the first week's treatment. No buprenorphine related changes in vital signs or laboratory values were observed and no signs of tolerance or physical dependence were seen in the short term period after discontinuation of treatment. A significant positive correlation between buprenorphine plasma concentration and daily dose was observed but there was no correlation between plasma levels and pain relief.

Administration, Oral↗
PubMed1984

Suppression of C-fibre discharges upon repeated heat stimulation may explain characteristics of concomitant pain sensations.

Nociceptors with unmyelinated axons were recorded from the superficial radial nerves of 7 volunteers. A sequence of uniform radiant heat stimuli of 18 s duration, starting from an individually adjusted adapting temperature were used to raise the skin surface temperature by 6 degrees C to a painful level (41-43 degrees C). These stimuli followed each other at 3 different interstimulus intervals of 35 s, 70 s and 105 s, occurring in a random order. The subjects were asked to track the time course of the stimulus-evoked sensation by manipulating the length of a light bar. Adaptation and stimulus temperatures were chosen to induce sensations of heat and/or pain. All nociceptors studied responded to these stimuli with a phasic response of 3-5 s duration, often followed by a low frequency tonic discharge, lasting as long as the stimulus. No discharges were seen in interstimulus periods. Discharge rates during the phasic responses were linearly related to interval duration, whereas tonic discharges were not influenced by the preceding interval. In parallel readings of pain responses were lower up to the 10th second of the stimulus after short rather than after long intervals. These results indicate that the suppression of C-fibre nociceptor discharges during repetitive stimulation may explain concomitant reductions in the magnitude of human pain sensations.

Adult↗
PubMed1984

Nociceptor discharges and sensations due to prolonged noxious mechanical stimulation--a paradox.

Forceps were used to induce controlled squeeze stimuli to small skin folds of the dorsal surface of the hand of human volunteers. Psychophysical and microneurographic experiments were performed to characterize sensations and afferent input induced by stimuli exerting a constant force during a period of 120 s. The psychophysical data showed that forces greater than 4 N exerted on forceps faces of 30 mm2 elicited pain, which had two main characteristics: (a) stronger stimuli evoked a stronger pain response, (b) pain had a tendency to increase throughout the 120-s stimulus duration. In contrast, discharges of polymodal C-fibre nociceptors showed an initial high frequency dynamic discharge followed by adaptation. It was found that the ratio of C-fibre activity to activity in myelinated SA-fibres provided a better correlate of the time course of the stimulus-induced pain sensations than C-fibre activity alone. Possible reasons for the mismatch between nociceptor input and pain sensations are discussed.

Afferent Pathways↗
PubMed1981

Some considerations on the pharmacological treatment of pain.

Drug treatment of pain is largely based on clinical experience. Some aspects of the analgesic therapy with drugs are discussed on the hand of data, selected from the scientific literature, or obtained by own experimental work done in the pain clinic of Leuven. The choice of the analgesic compound and some valuable drug combinations are reviewed. Possibilities for the evaluation of the analgesic efficacy, other as the simple but most important verbal report, are mentioned. Problems, associated with a prolonged analgesic drug therapy, are discussed. (Acta anaesth. belg., 1981, 32, 13-20).

Analgesics↗
PubMed1980

Latencies of chemically evoked discharges in human cutaneous nociceptors and of the concurrent subjective sensations.

Percutaneous recordings from single nociceptive A delta- and C-fibers have been performed from the superficial radial nerves of conscious human subjects. Nociceptors were tested with a chemical irritant substance, which induced a burning sensation when applied to the intact skin. A comparison of the onset of spike discharges in nociceptors and the onset of the subjective burning sensation indicated that under the conditions of our experiments summation of input from nociceptors is needed in order to induce pain sensations. In particular, our results indicate spatial summation.

Adult↗
PubMed1980

The treatment of cancerpain with analgesic drugs.

The use of analgesic drugs is only one part of a multidisciplinary approach which offers also other possible palliative procedures for pain therapy. Pain complaints are placed against the background of terminal illness. The use of analgesic drugs and their combinations is discussed, with a short reference to their mechanism of action. The way of adminstration may have some impact on the efficacy of the analgesic regimen. Side effects and concomitant medication are reviewed.

Amphetamines↗
PubMed1978

The influence of staff and personnel on the safety of the patient during anesthesia.

The safety of the patient under anesthesia is directly correlated to the quality of the service delivered by the anesthetic department. A good organised work, supposes a staff, which accords to numerical and qualitative requirements. The number of personal required is a function of working conditions. The quality required for the persons who administer anesthesia, depends upon the intrinsic danger of the procedure. As the nature of anesthesia is still linked with the acute control of vital functions of the patient, the qualifications of the person who administer the narcosis should be of the highest level.

Anesthesia↗
PubMed1976

Medical treatment of intermittent claudication: a comparative double-blind study of suloctidil, dihydroergotoxine and placebo.

Forty-five patients suffering from intermittent claudication were admitted to a double-blind non-crossover study. Three groups were constituted at random and treated for 2 months with either 100 mg suloctidil t.i.d. or 1.5 mg dihydroergotoxine methylate t.i.d. or placebo. From the results of measurements of pain-free walking distance and venous occlusion plethysmography recordings, suloctidil was shown to be active and significantly superior to dehydroergotoxine and placebo: in the two latter groups a decrease in calf blood perfusion after 2 months was also noted. The physician's overall assessment of response to treatment showed that suloctidil and dihydroergotoxine were significantly superior to placebo, and that suloctidil was significantly better than dihydroergotoxine.

Aged↗
PubMed1976

Double blind comparison of fentanyl and sulfentanil in anesthesia.

In a double-blind experiment fentanyl and sulfentanil were compared using three different anesthesia schedules. Only interventions of long duration were selected. In all three systems induction was carried out with 0.5 mg fentanyl or 0.05 mg sulfentanil, followed by etomidate and a muscle relaxant. Anesthesia was maintained with nitrous oxide and with repeated standard injection of the narcotic. In a first group reinjections always consisted of 0.1 mg of fentanyl or 0.01 mg of sulfentanil. In a second series reinjections were done with 0.5 mg of fentanyl or 0.05 mg of sulfentanil. In the third group the same reinjection schedule as in the first group was followed, but immediately after induction an injection of 1.25 mg of droperidol was administered. Both substances were compared as to their analgesic potency and their potential influences on hemodynamics. Special attention was also paid to postoperative ventilation and vigilance.

Adolescent↗
PubMed1976

Clinical use of buprenorphine in chronic administration.

Buprenorphine was used as an analgesic medication for patients at the pain clinic. Clinical observations on its long term administration for intractable pain are reported. A good analgesic activity was noted in most of the patients. Nausea and vomiting was the mean reason for cancellation of the therapy.

Administration, Oral↗
PubMed1976

Mistabron in the intensive care unit.

Mistabron is the trade-name of a new mucolytic agent, that has certain advantages over older mucolytic agents. This drug has been used to a great extent in patients with tracheobronchial secretions in the department of intensive care medicine. Its application makes expectoration easier while its preventive administration diminishes greatly the incidence of lung complications.

Humans↗
PubMed1975

Prazosin in the treatment of hypertension.

In two double-blind, randomized cross-over comparison studies undertaken in elderly subjects, a new quinazoline derivative, prazosin, has been shown to be a safe and effective antihypertensive agent to which there is a progressive response over four- to six-week periods of oral administration at fixed dose-levels.

Administration, Oral↗