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Biomedical subjects

H Adriaensen

Publications and source records attributed to H Adriaensen.

At least 37 records · Page 2Linked to original sources
PubMed1992

Safety aspects of PCA.

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Analgesia, Patient-Controlled↗
PubMed1991

Intracranial subdural hematoma after spinal anesthesia.

We describe a 68-year old male patient with late onset signs of an intracranial subdural hematoma after repetitive spinal anesthesia procedures for urethral dilatation. The proposed mechanism is that of cerebrospinal fluid efflux. The potential for the development of such complications is so important, that it must be considered in every patient.

Aged↗
PubMed1991

The effects of a single oral dose of lorazepam and alprazolam on reaction times in young healthy volunteers.

Lorazepam (Temesta) and alprazolam (Xanax) are two benzodiazepines which are widely used for their anxiolytic activity. In this study their effect on psychomotor functions was investigated. Eight young healthy volunteers participated in the experiments. Using a double-blind cross-over design, the effect of single oral doses of lorazepam (2.5 mg) and alprazolam (0.5 mg) on a choice reaction time test to visual stimuli (letter pairs presented on a computer screen), were assessed. The experimental procedure consisted of three sessions which differed from each other either by the stimulus presentation rate, or by the presence or absence of a warning signal. In all three sessions, lorazepam, when compared with placebo, significantly prolonged the reaction times (RT), while alprazolam did not. Increasing the interstimulus interval resulted in an equal increase of the reaction times in the three conditions. On the other hand, the introduction of a warning signal which preceded the presentation of the letter pairs, improved performance in the three conditions. This improvement was more pronounced after lorazepam than after placebo. This finding is interpreted as a partial recuperative effect for the impaired performance in the baseline condition after intake of lorazepam.

Administration, Oral↗
PubMed1990

Comparison of epidural sufentanil plus clonidine with sufentanil alone for postoperative pain relief.

Sufentanil 25 micrograms plus clonidine 1 microgram/kg administered epidurally was compared with epidural sufentanil 50 micrograms alone in a double-blind fashion for pain relief in 40 patients after abdominal surgery. The duration of complete pain relief was significantly longer in those who received the mixture. Oxygen saturation was reduced 10 and 20 minutes after sufentanil alone, but remained stable after sufentanil and clonidine. There were significant decreases in arterial blood pressure in the latter group that were maximum between 20 and 120 minutes after administration.

Adult↗
PubMed1990

Effects of anesthetics on the coronary circulation.

The coronary circulation holds a unique position among the different vascular beds because it perfuses the organ that generates the perfusion pressure for the entire circulation. Therefore the maintenance of an adequate perioperative coronary flow is one of the primary goals of good anesthetic management. This is especially important when coronary flow is already diminished such as is the case with arteriosclerotic disease. All anesthetics influence coronary flow to some extent. Some of them however also affect the normal physiologic responses of this system and may compromise coronary circulation and hence myocardial function. Therefore, knowledge of the coronary physiology and the effects of anesthetics on it is essential for every anesthetist dealing with patients with coronary artery disease. This article reviews the anatomy and physiology of the coronary circulatory system and resumes the present state of knowledge of the effects of the common used anesthetics on the coronary circulation.

Anesthetics↗
PubMed1990

Effects and early perioperative diagnosis of graded reductions in regional coronary perfusion.

The effects of graded reductions and total occlusion of the flow in a small branch of the coronary circulation on regional myocardial function and metabolism and routinely monitored determinants of myocardial function, such as body surface electocardiogram, pressure tracings and dP/dt, are evaluated in mongrel dogs. Normal regional myocardial function and pH remain preserved until coronary blood flow is reduced to about one half its normal initial value. Then, important and dramatic changes in systolic regional myocardial function occur together with a significant decrease in regional pH. There were no significant changes in the global determinants of myocardial function. This study proves the inadequacy of the body surface electrocardiogram and the other routinely monitored hemodynamic determinants to detect limited regional ischemia. In addition, it stresses the importance to evaluate the sensitivity of new monitoring techniques in the detection of regional myocardial malfunctioning and the importance of research on the effects of anesthetic agents on regional myocardial function.

Animals↗
PubMed1990

Perioperative intra-aortic balloon counterpulsation in cardiosurgery: a retrospective study.

From January 1986 to March 1988 50 of 1366 patients (3.7%) undergoing cardiac surgery were treated with IABP support. The 50 patients ranged in age from 43 to 79 years (mean: 63.3 years). 88% of them underwent coronary artery bypass grafting, 6% of them mitral valve replacement and the other 6% a combined procedure. IABP was inserted preoperatively in 4 patients (8%) because of cardiogenic shock, and in 18 patients because of unstable angina (36%); intraoperatively as a help during weaning from cardiopulmonary bypass in 8 patients (16%); postoperatively because of hemodynamic deterioration in 20 patients (40%). The IABP was placed by femoral puncture in 39 patients (78%), by femoral cutdown in 6 patients (12%) and by transthoracic aortotomy in 5 patients (10%). All patients received daily infusions of heparin and broad spectrum antibiotics. The overall incidence of complications was 22%. There was no mortality due to IABP-related complications.

Adult↗
PubMed1989

Evaluation of a brief chronic pain management program: effects and limitations.

The short- and long-term efficacy of a multidisciplinary pain management program was evaluated in a group of 35 chronic pain patients. At posttreatment, patients reported lower pain levels, more up-time, less medication consumption, an increase in positive cognitions about pain, and more (psychologically oriented) active coping. At follow-up, treatment gains were only partly maintained. A theoretical model regarding the impact of the treatment program was discussed. Plans for future efforts to enhance transfer and maintenance of therapeutic benefits were presented.

Adaptation, Psychological↗
PubMed1989

Mechanisms of anesthesia-induced depression of myocardial function.

Anesthetics may depress myocardial function. Part of this action is due to a direct negative inotropic effect of these agents. With the increasing knowledge on the cardiac excitation-contraction process, the understanding of the different possible mechanisms, underlying the anesthetic-induced myocardial depression also increases. The present state of knowledge on these possible mechanisms is reviewed and they are discussed as to their relative importance and their clinical relevance.

Adenosine Triphosphate↗
PubMed1989

Safety of labetalol-induced controlled hypotension during middle ear microsurgery.

In order to study the influence of labetalol on the peroperative oxygenation during deliberate hypotension, 50 patients undergoing middle ear microsurgery were randomly divided in two groups of 25 patients; one group receiving labetalol to induce hypotension, the other group receiving placebo in a double blind manner. In the group receiving labetalol the arterial oxygen tension (PaO2) decreased significantly 5 minutes after the intravenous bolus injection. Within 30 minutes the PaO2 returned to the starting level. The arterial carbon dioxide tension (PaCO2) increased within 5 minutes and also returned to the initial level after 30 minutes. These changes were absent in the control group. It is concluded that, although labetalol produces a statistically significant change in PaO2 and PaCO2, this finding has only minor clinical implications and so labetalol remains a safe drug to be used for the induction of deliberate hypotension during middle ear microsurgery.

Adult↗
PubMed1989

A comparison of the anaesthetic properties of propofol and methohexitone when used as the sole induction agent for thermocoagulation of the gasserian ganglion.

Methohexitone and propofol were compared when used as the sole induction agent for thermocoagulation of the Gasserian ganglion. Sleeping and apnoea times were not significantly different for both drugs, nor were they for the same drug during repetitive inductions. However, the haemodynamic data showed a better stability when propofol was used. Amnesia may be in favour of propofol. There were no significant differences concerning pre- and post-operative side-effects in both groups.

Aged↗
PubMed1988

Painful muscle spasms complicating algodystrophy: central or peripheral disease?

A 21 year old female patient developed Südeck's atrophy of the right foot secondary to a chronic Achilles tendinitis. The condition was complicated by the occurrence of painful muscle spasms in the right leg and incontinence of urine. The spasms had characteristics of both a tonic ambulatory foot response and a spinal flexor reflex. The movements disappeared during sleep. Regional anaesthesia of the right leg made the spasms disappear both in and outside the region of anaesthesia. Backaveraging of the EEG showed the involuntary spasms to be preceded by a cortical potential similar to a readiness potential, indicating a cortical potential similar to a readiness potential, indicating a cortical component in the pathophysiology of the muscle spasms complicating Südeck's atrophy.

Adult↗
PubMed1988

Current management of traumatic chylothorax.

The development of a traumatic chylothorax is an uncommon but serious clinical entity. Two cases of traumatic chylothorax are reported. The anatomy and physiology of the thoracic duct and the etiology, diagnosis and management of traumatic chylothorax are discussed.

Adult↗
PubMed1988

Parathyroidectomy and postoperative hypocalcemia: a retrospective study.

The data of 24 patients, operated for different types of hyperparathyroidism were reviewed in order to evaluate the evolution of calcium levels during the first week following surgery. A correlation with the preoperative values of alkaline phosphatase could be demonstrated. It may be concluded that in the primary affected patients a stay in the ICU, only for hypocalcemia-related problems, is not required. In secondary hyperparathyroidism however, the more spectacular drops of calcium levels and the risk of other vital complications, justify a follow-up in the ICU for at least 48 hours.

Adolescent↗