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Biomedical subjects

H Abe

Publications and source records attributed to H Abe.

At least 1,459 records · Page 81Linked to original sources
PubMed1983

[Evaluation of radiation immunochemotherapy in the treatment of malignant glioma. Combined use of ACNU, VCR and PS-K].

In a follow up study of 38 patients with supratentrial malignant glioma verified histologically during the 3 years from 1979 to 1982, the same therapeutic method which was the postoperative synchronized radiation-immunochemotherapy was applied. And we investigated the relationships between the survival rate and the histological malignancy, the operative area, and age of admission. Total dose of 5000 to 6000 rad radiation was given after surgery. 0.02 mg/kg of VCR was administered intravenously on the first and the 29th day of radiation, and 2 mg/kg of ACNU was administered intravenously 24 hours after VCR administration. After synchronized radiotherapy, 2 mg/kg of ACNU was given every 6 weeks and 3 g of PS-K was given orally every day. Dose of PS-K was increased especially during the radiation and for 2 weeks after ACNU administration. This radioimmunochemotherapy was applied to 38 patients with malignant glioma, 25 cases of glioblastoma multiforme, 12 cases of malignant astrocytoma, one cases of malignant ependymoma, one case of malignant oligodendroglioma. A complete clinical course of all patients was observed. 18 of 38 cases are surviving. The survival rate of malignant gliomas was 71.2% for one year, 47.6% for 2 years, 34.8% for 3 years. The survival rate of glioblastoma was 56.3% for one year, 36.9% for 2 years, 12.3% for 3 years. The survival rate of the patients receiving macroscopically total removal was higher than that of the patients receiving subtotal removal. The survival rate of the younger patients (under 49 years old) was higher than that of the older patients (over 50 years old). Side effect of this therapy was myelosupression in 75.8%.

Adjuvants, Immunologic↗
PubMed1983

Influence of chronic renal failure on protein synthesis in rat liver and muscle.

Protein-synthetic activity in the liver and muscle of rats with chronic renal failure (CRF) of 2 weeks' duration was studied by examining RNA/DNA ratios and polysome profiles and in vitro protein synthetic activity of isolated polysomes. CRF was found to cause differential effects on protein synthesis in the liver and muscle. In the liver, CRF caused impairment of protein synthesis only in the fed condition; CRF rats maintained the same "basal" protein synthetic activity as the sham-operated control rats upon 18 hours' starvation. In the muscle, the effect of CRF was manifested only in the starved condition; CRF caused extensive disaggregation of polysomes when animals were starved. It is proposed that the muscle serves as a "reserve" protein when animals sustain a protein-catabolic state such as CRF.

Animals↗
PubMed1983

[Facial nerve reconstruction--after the operation of C-P angle tumor].

Nineteen patients who undergo facial nerve reconstruction after the operation of cerebellopontine angle tumor from 1964 to 1981 were investigated. Eighteen cases were of acoustic neurinoma, and one was of low grade astrocytoma. Spinal accessory-facial nerve anastomosis was performed in thirteen cases. Cross facial nerve graft was done in three cases. Hypoglossal-facial nerve anastomosis, phrenico-facial nerve anastomosis, and intracranial direct anastomosis were done in one case each. In spinal accessory-facial nerve anastomosis cases, good result was obtained only in 30%, but using microsurgical technique since 1972, its rate went up to 50%. In cross facial nerve anastomosis cases in which two sural nerve grafts were used and the zygomatic and the buccal branches of the right and left connected each other, only one of three revealed good result. The cases of hypoglossal and intracranial direct facial anstomosis resulted in good recovery. As our conclusion, it is difficult to obtain the powerful reinnervation by means of the spinal accessory facial nerve anatomosis and the cross facial nerve graft. Therefore, the best method to be chosen in facial nerve reconstruction seems intracranial direct anastomosis. If the method is impossible, hypoglossal-facial nerve anastomosis should be chosen as the second best. The cross facial nerve graft seems to be leaving much room for technical improvement.

Accessory Nerve↗
PubMed1983

[Surgical management of arteriovenous malformations in the posterior fossa].

The authors reported 3 cases of dural arterio-venous malformation (AVM) in the posterior fossa and discussed mainly on surgical treatment. Case 1: 53-year-old man was admitted to our clinic with complaints of amnesia, visual impairment, dysarthria and gait disturbance. Neurological examination on admission disclosed slight disturbance of consciousness, bilateral papilledema, horizontal nystagmus, dysarthria and ataxic gait. Contrast CT showed a presence of vermiform irregular high density with enlarged ventricle, indicating phlebectasia in the brainstem and the cerebellum. Angiograms revealed a presence of dural AVM at the straight sinus fed by branches of external carotid artery and vertebrobasilar circulation with appearance of phlebectasia due to increase in straight sinus pressure on later phase. Dural sinus isolation for the affected sinus was performed under large occipital craniotomy which was initially reported by Hugosson and Bergström. Case 2: 55-year-old man was admitted to our hospital with complaint of gait disturbance. Neurological examination at the time of admission disclosed signs of raised intracranial pressure and caudal cranial nerves disturbance. Bruit synchronized with radial pulse was audible over the left occipital region. Angiograms showed a presence of dural AVM at the left transverse and sigmoid sinus with many feeding arteries and abnormal venous returns. Isolation of the involved sinuses was performed as same as in case 1. Case 3: 39-year-old woman was admitted to our clinic with complaints of protrusion of eyes and uncomfortable machinery noise over the right retromastoid region.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

Hereditary multisystemic degeneration with unusual combination of cerebellipetal, dentato-rubral, and nigro-subthalamo-pallidal degenerations.

An autopsy case of a 51-year-old housewife with dominantly inherited ataxia is reported. Pathologic examination revealed an unusual combination of systemic degenerations: spinocerebellar tracts, pontine basis and middle cerebellar peduncles, dentato-rubral and nigro-subthalamo-pallidal systems, upper and lower motor neurons, ascending sensory system, and optic tracts. The inferior olive and cerebellar cortex showed only a slight change. The combination of the dentato-rubral with nigro-subthalamo-pallidal degenerations in a case with cerebellipetal systemic degeneration was particularly striking. Furthermore, combined degeneration of the ocular motor nuclei, vestibular nuclear group, perihypoglossal nuclei, fastigial nucleus, medial longitudinal fasciculus, and vestibulospinal tracts occurred. According to recent experimental results, these lesions were restricted precisely to the anatomophysiologically interrelated system for the control of eye movement. The present case is considered an example of systemic degeneration as a pathologic basis for ophthalmoplegia.

Brain Diseases↗
PubMed1983

[Functional recovery following surgical removal of traumatic epidural hematoma--factor analysis].

UNLABELLED: Factors contributing to functional recovery following evacuation of epidural hematoma were analyzed in 53 subjects. Subjects were limited to the cases with "pure" epidural hematoma. Fifty-three cases were classified into 3 groups based on presence or absence, and duration of preaggravation period (PAP) following occurrence of head trauma (Fig. 1). Level of consciousness at operation and at PAP is summarised in Fig. 2. Major neurological signs at operation are summarized in Table 1. Gradings of functional status were divided to 6 (Table 2). Gradings of 53 subjects which were judged 1 month after removal of epidural hematoma are summarized in Fig. 3. RESULTS: 1) As to outcome in relation to duration of preaggravation period (PAP) and consciousness level at operation (Fig. 4): The patients whose PAP was shorter and whose consciousness level at operation was more severe, took outcome of lower (worse) gradings. 2) As to outcome in relation to interval from the end of PAP to operation and PAP (Fig. 5): The patients whose PAP are within 3 hours, took outcome of relatively good recovery only when epidural hematoma was removed within 5.5 hours after the end of PAP. 3) As to outcome in relation to interval from the end of PAP to operation and consciousness level at operation (Fig. 6): The patients whose consciousness level at operation was better than semicoma took good recovery when epidural hematoma was evacuated within 5.5 hours after the end of PAP. This was right even in the patients who presented with decerebrate posture.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1983

[Surgical management of trigeminal neuralgia, hemifacial spasm, paroxysmal tinnitus and nystagmus by neurovascular decompression].

Trigeminal neuralgia, facial spasm, tinnitus, vertigo, and glossopharyngeal neuralgia are believed to be the symptoms complex of hyperactive dysfunction of the cranial nerve caused by vascular cross compression at the root entry (exit) zone of the appropriate nerve. Posterior cranial fossa approach for the neurovascular decompression was enhanced by Jannetta et al (1975). From their experiences of surgery, they emphasized that these symptoms were relieved by surgery. In this report, we will discuss the etiology of the disease, the neurotological examination, the angiographic findings, the operative findings and results in a series of 10 patients who have undergone neurovascular decompression. The series consisted of 4 cases with trigeminal neuralgia, 5 cases with facial spasm, and 1 case with paroxysmal tinnitus accompanied by facial spasm. The postoperative progress in these all patients was excellent and relieved of the symptoms. There was neither mortality nor any significant complication. We stress that the neurovascular decompression surgery is now well justified as the definite treatment for the trigeminal neuralgia and facial spasm, because the surgery can be performed easily and safely by the neurosurgeons. The indication of the neurovascular decompression for the acoustic nerve and glossopharyngeal nerve is still controversial. In our own case, tinnitus was paroxysmal and complicated with facial spasm, not synchronous with facial spasm, but with nystagmus. This selective synchronism between tinnitus and nystagmus is a particular feature of our clinical instance. This particular clinical experience may provide some highly significant suggestions in considering the applicability of neurovascular decompression to the acoustic nerve.

Aged↗
PubMed1983

[Fracture of the penis: report of 10 cases and a review of 231 cases in Japan].

Ten cases of fracture of the penis were experienced between 1961 and 1981 at our Department. In all cases, the penis was swollen and distorted by a subcutaneous hematoma. No hemorrhagic discharge from urethra was seen. The patient's age was between 19 and 57 years. The causes of these fracture were coitus in 3 cases, manipulation in 4 cases (including one masturbation case), inverting in 2 cases, and the last case resulted from the patient's rolling over in bed. Surgical repair was performed on all patients. The causes, diagnosis, therapy and prognosis of 231 cases of fracture of the penis reported in the Japanese literature between 1934 and 1982 are reviewed.

Adult↗
PubMed1983

[Retroperitoneal lipoma: report of a case].

A case of retroperitoneal lipoma is reported. The patient came to our hospital with the complaint of an abdominal mass. The pathological finding was benign lipoma. The diagnosis, therapy and prognosis of 51 cases of the disease collected from the Japanese literature are reviewed.

Aged↗