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Biomedical subjects

H A Sande

Publications and source records attributed to H A Sande.

35 records · Page 2Linked to original sources

Carcinoma of the colon in pregnancy.

Carcinoma of the large bowel in association with pregnancy is extremely rare. A case report is presented, where the patient had a malignant tumour in the sigmoid colon with metastases in the liver. The diagnosis was made at caesarean section after acute onset of symptoms 3 weeks prior to the expected date of delivery. The case is discussed in some detail.

Adenocarcinoma↗

Alpha-fetoprotein concentration in maternal serum and abortion via VA and PGF2alpha.

Most women undergoing abortion by vacuum aspiration (VA), extraamniotic prostaglandin instillation or vaginal prostaglandin suppositories showed a significant rise in their serum alpha-fetoprotein (AFP) concentrations during the procedure. We suggest this rise is due to a fetomaternal hemorrhage during the abortion procedure. Few women undergoing VA before 9 weeks' gestation showed this rise in serum AFP. To avoid fetomaternal hemorrhage during pregnancy termination, we recommend abortion by VA in early pregnancy.

Abortion, Therapeutic↗

Treating dysmenorrhea with anti-inflammatory agents: a double-blind trial with naproxen sodium.

Thirty-two dysmenorrheic patients participated in a double-blind trial of naproxen sodium for three consecutive menstrual cycles. The women were divided into two groups: 15 women were given naproxen sodium (the sodium salt of d-2-(6-methoxy-2-naphthyl) propionic acid) and 17 women received placebo tablets. The women were prescribed two tablets (550 mg) at the first sign of menstrual pain and one tablet (275 mg) thereafter every six hours, as required. There were no significant differences between the two groups in physical characteristics, obstetric and gynecologic histories, including the character of dysmenorrhea and pretreatment pain intensity scores (p = 0.7). Following intake of the drug or placebo, the participants rated the relief provided by the medication with a six-point scoring system. When the scores for pain relief were tallied for the three treatment cycles, the naproxen sodium group averaged 13.7 +/- 0.65 standard error, while the placebo group averaged 8.8 +/- 0.95 standard error out of a possible maximum relief score of 18. The difference between the two groups was statistically significant at p = 0.0004. Few patients reported side effects.

Clinical Trials as Topic↗

Alpha-fetoprotein: a marker for threatened abortion.

The role of alpha-fetoprotein (AFP) as a marker for threatened abortion was investigated in 50 patients and compared with the roles of serum human chorionic somatomammotropin (HCS) or human placental lactogen (HPL) and human chorionic gonadotropin (HCG). Of the 50 patients admitted to the hospital with threatened abortion, 30 patients aborted and 20 gave birth to live-born babies. Twenty women aborted within seven days of admission. Eighty-two percent (82%) of the 20 had abnormal AFP values: one third were above the 97.5 percentile and two thirds were below the 2.5 percentile. The AFP values were normal in almost all cases in the group who aborted after seven days. The HCG level in serum was found to be the best indicator of threatened abortion. the AFP and HCS levels were equal indicators of threatened abortion, but were not as reliable as the HCG levels The AFP values are of more diagnostic use than the HCS values, however, because both abnormally low and high AFP levels can indicate an unfavorable course in pregnancy.

Abortion, Threatened↗

Evaluation of threatened abortion by human chorionic gonadotropin levels and ultrasonography.

To determine the prognostic value of human chorionic gonadotropin (HCG) concentrations in maternal plasma and urine, we studied 104 women with threatened abortion (cases) and 108 women with normal pregnancies and normal serum levels of HCG (controls). Of the 104 cases, 48 were also examined ultrasonically. We concluded that measurements of serum levels of HCG are of more accurate prognostic value than those of urine levels. Low serum levels of HCG indicate a poor prognosis for the pregnancy, as do steady decreases, in repeated measurements, of initially high HCG level. The combination of normal serum levels of HCG and signs of fetal life during ultrasonic examination indicates a very good prognosis for the pregnancy.

Abortion, Spontaneous↗