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Biomedical subjects

G Zenker

Publications and source records attributed to G Zenker.

At least 19 recordsLinked to original sources

[Management of acute intrathoracic aortic dissection].

At the intensive care station of the Internal Medicine Department, University Clinic Graz, all patients admitted were promptly and carefully examined in case of suspected acute intrathoracic aortic dissection and immediately treated. In 1987 a total of 4446 patients were referred to this CCU, 893 suffered from acute thoracic pain. In 21 patients of the latter a clinical suspicion of aortic dissection was observed. In 9 patients of these, diagnosis could be established within 5 hours by echocardiography, CT and angiography. 11 patients had no dissection while one positive finding could only be determined by postmortem exam. Retrospectively, these figures for 1982 were 3908 admitted patients, 790 suffering from acute thoracic pain of which only 5 showed suspected dissection. In 3 cases dissection could be confirmed using the same diagnostic procedures, but 2 were without finding. Further 3 patients out of the total series were affected with dissection which could only be determined postmortem. Out of the 9 patients with positive diagnosis, 6 showed Typ I, 1 Typ II and 2 Typ III dissection according to DeBakey (8m, 1f, range 46-78 years). 2 patients underwent surgery immediately after diagnosis, 1 after 12 hours, while 4 cases were conservatively treated. These 7 patients have survived by controlled hypotension up to now (10 to 22 months). Two patients died 2 and 10 hours, respectively, after admission with positive diagnosis. In spite of the severity of this disease prompt and efficient diagnosis and rapid therapeutic management are the key to survival.

Aged

Semiquantitative grading of mitral regurgitation by color-coded Doppler echocardiography.

We evaluated patients with mitral regurgitation by color-coded Doppler echocardiography using a semiquantitative score system, which is useful in the clinical setting, by providing rapid discrimination between mild, moderate and severe regurgitation. The study was performed in 42 patients (19 female, 23 male) mean age 58 years, range 23-75 years with mitral regurgitation of different etiology. Color-coded Doppler measurements were compared to angiographic findings using a three point score system. In addition to such parameters as maximal jet length, area and the ratio jet area/left atrial area, we also considered the duration of regurgitant flow. The best correlation was obtained for the maximal area of the jet multiplied by the duration of regurgitant flow/cycle length (r = 0.88), determined in the apical plane where the jet was best visualized. For the parameter area of jet alone, the correlation coefficient was 0.81, for the length of the jet the value was r = 0.65 and comparison of the areas of jet and left atrium gave a coefficient of 0.77. A clear separation between mild and severe regurgitation was observed only for the parameter calculated by multiplying the area of the jet by the duration of mitral regurgitation. In only 7% of the patients with moderate and severe regurgitation could we observe an overlap. This parameter, therefore, represents a useful method for estimating in a semiquantitative manner the severity of mitral regurgitation by color-coded Doppler echocardiography.

Adult

Flow patterns of mitral regurgitation due to different etiologies: analysis by color-coded Doppler echocardiography.

We have used cross-sectional real time color-coded Doppler echocardiography to characterize the patterns of the regurgitant jet seen in mitral valvar disease of different etiologies. We studied 118 patients with mitral regurgitation due to rheumatic valve disease (n = 26), hypertrophic obstructive cardiomyopathy (n = 22), dilated cardiomyopathy (n = 35) and prolapse of the leaflets of the mitral valve (n = 35). We analyzed the origin, spatial distribution, extent and duration of the regurgitant jet. A semiquantitative grading system was used to evaluate the extent of the jet by measuring its maximal area and the duration of regurgitant flow. Typical flow patterns could be observed in hypertrophic obstructive cardiomyopathy, (in which the crescent shaped jet was elongated in midsystole and directed posteriorly) in dilated cardiomyopathy (in which oval shaped jets were observed throughout systole) and in prolapse of the leaflets (in which early or late systolic regurgitant jets occurred with an eccentric "drop-like" pattern, being directed posteriorly in patients with a prolapse of the aortic leaflet and anteriorly in those with a prolapse of the mural leaflet of the valve). A large variety of patterns was found in rheumatic disease due to the individual deformation of the leaflets. A comparison of the measured area of the jet revealed no significant differences between regurgitation caused by rheumatic valve disease and dilated cardiomyopathy. The regurgitation in 80% of these patients was of moderate to severe degree. In contrast, regurgitation due to prolapse of the leaflets or hypertrophic obstructive cardiomyopathy appeared to be of mild to moderate degree in 90% of cases.

Adult

Transesophageal two-dimensional echocardiography in young patients with cerebral ischemic events.

Using transesophageal echocardiography, cardiac structures can be imaged with high resolution. The aim of our study was to evaluate whether transesophageal echocardiography is superior in detecting mitral valve prolapse and other cardiac abnormalities compared with transthoracic echocardiography in an age-matched control group and in young patients with cerebral ischemic events (patient group). Forty patients with cerebral ischemic events (mean age 35.2 years) and 29 controls (mean age 30.4 years) were examined using both methods. Transthoracic and transesophageal echocardiography showed a significantly higher incidence of mitral valve prolapse in the patient group compared with the control group (p less than 0.001). By means of transesophageal echocardiography, it was possible to measure highly significant bulging in both the anterior and the posterior mitral leaflet in the patient group compared with the control group (p less than 0.001), and the thickness of the mitral leaflets was significantly higher in the patient group. In 9 of 20 (45%) patients with normal transthoracic echocardiograms, transesophageal echocardiography showed pathologic findings. We found transesophageal echocardiography to be a sensitive method for detecting mitral valve prolapse as well as valve changes and other cardiac abnormalities not detectable by conventional echocardiography. Our study underlines the role of mitral valve prolapse in young stroke patients as a relevant risk factor and emphasizes the importance of changed mitral valve morphology.

Adolescent

[Clinical significance and expanded diagnostic possibilities by transesophageal echocardiography].

Two-dimensional echocardiography is already a well-established diagnostic tool for evaluation of cardiac diseases. The introduction of two-dimensional transesophageal echocardiography (TEE) has widened the ultrasonic examination possibilities of the heart and great arteries. In 15% of patients where two-dimensional echocardiography gave false - negative results, TEE detected vegetations on the mitral and aortic valves. The sensitivity for detection of atrial septal defect in comparison with angiocardiography is 100%. TEE appears to be a useful noninvasive method for bedside diagnosis of acute aortic disease, particularly type III De Bakey dissections. In anaesthesiology, cardiac surgery and intensive care medicine TEE is used for simultaneous left ventricular function analysis and for detection of microair embolism. TEE is highly sensitive in the detection of mitral and aortic valvular disease, changes of the interatrial septum, left atrium and of the thoracic aorta.

Aorta, Thoracic

[Color Doppler echocardiography: expanded noninvasive cardiologic diagnosis].

Two-dimensional color Doppler flow mapping (CD) provides actual information concerning the spatial distribution of blood flow within the heart and the great vessels. CD enables the differentiation between physiological and pathological blood flow situations and provides additional information concerning turbulence, velocity and spatial relations. Thus rapid semiquantitative assessment of regurgitant lesions, detection of eccentric jets across stenotic valves and imaging of intracardiac shunts is possible. The development of CD represents an important improvement regarding noninvasive cardiology.

Color

[Basedow's disease and mitral valve prolapse].

The prevalence of mitral valve prolapse was investigated in 60 patients with Graves' disease (42 with ophthalmopathy) and in 20 patients with toxic nodular goitre. 2410 patients from the echocardiography laboratory served as controls. Standard M-mode, Doppler and two-dimensional echocardiography were performed. Mitral valve prolapse was defined as a systolic buckling greater than or equal to 3 mm. In patients with thyroid disease HLA antigens were determined. Patients with Graves' disease showed a significantly higher incidence of mitral valve prolapse (36/60, 60%) compared to the group with toxic nodular goitre (2/20, 10%) and to controls (238/2410, 9,9%) (P less than 0.0001). 16 of 36 patients had a prolapse of the anterior, in 3 of 36 the posterior leaflet was involved and 17 of 36 had both. Mean systolic buckling was 4.3 +/- 1.5 mm. 28 of 42 patients with ophthalmopathy (67%) showed a mitral valve prolapse. 20 of 60 patients (33.3%) with Graves' disease but none in the goitre group showed a thickened myxomatous valve (P less than 0.001). Thyroid function did not influence the incidence and intensity of the prolapse. The HLA phenotypes B8 were seen in 22 of 36 and DR3 in 24 of 36 patients with mitral valve prolapse. Since thyroid function was comparable in both groups an involvement of the mitral valve in an autoimmune process affecting several organs can be considered probable.

Adult

[Bronchospasmolytic effectiveness of controlled drug combinations].

Two groups of 10 patients each with a chronic obstructive pulmonary disease were the subjects of a comparative study of the effectiveness of 240 mg theophyllinethylendiamine (Euphyllin) and a combined medication consisting of 25 mg theophyllin, 85 mg etophyllin, 30 mg papaverine and 0.1 mg atropine methylnitrate (Perphyllon). Oscillatory resistance (measured with the Siregnost FD 5) and the circulatory parameters pulse and blood pressure were studied. A statistically significant bronchospasmolytic effect was found for both substances administered parenterally. It was shown, however, that the combined medication worked faster, longer and 4 to 5 times more effectively than theophyllinethylendiamine. The possible causes of the differences are discussed. Clinically, the cardiovascular side effects of the combined medication are to be classified as slight. The tested medication has a favorable therapeutic spectrum as a result of the low dosage of the individual substances.

Airway Resistance

BTPS correction with dynamic spirometers.

In order to determine the requirements for a proper temperature correction of expired volumes, the temperature of the expired air in the bellows of a dynamic spirometer (Vitalograph) was measured in 10 and 5 subjects at 24 and 12.2 degrees C ambient temperature, respectively. During the short period of forced expiration there was a significant temperature decrease, which showed a linear relationship to the ambient temperature. Temperature differences up to 12-15% occurred within seconds; consequently, the values obtained in bellows-type spirometers for FEV1 and FVC have to be corrected to BTPS at room temperature. There was no correlation between the degree of temperature decrease and the magnitude of expiratory volume. For routine clinical work it suffices to use the room temperature as the variable.

Adult

[The effect of pirenzepine on lipase levels after endoscopic retrograde cholangio-pancreaticography].

In a random examination including 40 patients with previous endoscopic retrograde cholangio- pancreaticography (ERCP) the influence of pirenzepine on the lipase elevation through filling of the pancreatic duct with a contrast medium was studied. The result of this study is that, compared with a control group, pirenzepine reduces significantly ERCP-caused hyperlipasemias. Therefore we can recommend the prophylactic application of pirenzepine before ERCP.

Cholangiopancreatography, Endoscopic Retrograde