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Biomedical subjects

G Wolfram

Publications and source records attributed to G Wolfram.

At least 217 records · Page 12Linked to original sources
PubMed1976

[Treatment of hyperlipidaemia. A comparison of the efficacy of clofibrate and beta-pyridylcarbinol (author's transl)].

64 patients with hyperlipidaemia, 13 of them with pure hypercholesterolaemia, were assigned to one of three pre-determined treatment regimes over a period of seven months. Two different commercial preparations of clofibrate and one preparation of beta-pyridylcarbinol were each given for two months separated by placebo periods of two weeks. All three drugs were equally effective against increased cholesterol levels. The two clofibrate preparations lowered increased triglyceride levels more reliably than beta-pyridylcarbinol.

Cholesterol↗
PubMed1976

[Treatment of hyperlipemia and hyperuricemia with 2-acetamidoethyl-(4-chlorophenyl)-(3-trifluoromethylphenoxy)-acetate (halofenate), a derivative of clofibrate].

23 patients with hyperlipidemia and hyperuricemia received acetamidoethyl-(4-chlorophenyl)-(trifluoromethylphenoxy)-acetate (halofenate), a clofibrate derivative, and probenecid or probenecid and placebo over 36 weeks following a placebo period of 6 weeks. Halofenate compared with probenecid lowered elevated serum uric acid levels satisfactorily to a therapeutic level between 5 and 6 mg/100 ml. Serum triglyceride levels were not always lowered sufficiently, serum cholesterol levels were not influenced.

Cholesterol↗
PubMed1975

[The effect of cane sugar on serum lipids (author's transl)].

The relationship between the carbohydrate content of foods and the serum lipid levels are demonstrated in connection with the hypothetical relation between increased sugar consumption and myocardial infarction. The increase in serum triglyceride levels in healthy subjects after a diet rich in carbohydrates in influenced by several factors such as energy balance, absolute quantity of carbohydrate, individual response of the test person, etc. With the aid of a dietary formula trial in healthy adults, saccharose consumed in usual quantities is shown to cause no increase in triglyceride or cholesterol levels.

Adult↗
PubMed1975

[Lipoatrophic diabetes. Report of a case (author's transl)].

Lipoatrophic diabetes is characterized by: complete lack of subcutaneous fattissue (generalized lipodystrophy), insulin resistant diabetes mellitus, hepatosplenomegaly, excessive hyperthyroidism, elevated basal metabolic note without hyperthyroidism. Recently, "cystic" alterations in the bone have been described as a possible further characteristic. The case of a young woman, now aged 21, who has had generalized lipodystrophy for 17 years and overt diabetes mellitus for 6 years is reported.

Adult↗
PubMed1975

[Effects of formula diet with varying carbohydrate proportion on gut microflora in man].

The effects of conventional food and of formula diet on gut microflora were tested in six healthy persons. In comparison with conventional food, the total gut microflora concentrations slightly increased during formula diet with oligosaccharides. During the periods of formula diet rich in sucrose of maltose, total flora concentrations declined. These changes of total gut microflora were especially caused by the increase and decrease of the enterococci and enterobacteria, the bacteroides showing rather small changes. The concentrations of lactobacteria, sporeforming bacilli and yeasts decreased rapidly with formula diet and did not increase again until normal food was supplied.

Adult↗