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Biomedical subjects

G Wolf

Publications and source records attributed to G Wolf.

At least 613 records · Page 34Linked to original sources
PubMed1983

Concentration and subcellular localization of zinc in the hippocampal formation, cerebellum, and whole brain during the postnatal development of the rat.

Zinc was determined by means of atomic absorption techniques in the hippocampal formation, the cerebellum, the whole brain, and their subcellular fractions during the postnatal development of rats. Large quantities of zinc were found already in newborn animals. In the whole brain, the zinc amounts increased between the birth and the 15th day of age, whereas in the hippocampal formation and cerebellum the zinc concentration did not change remarkably during the postnatal maturation. The zinc content of the subcellular fractions revealed a shift to the synaptosomes and mitochondria during the postnatal development. No significant difference of zinc amounts was shown between the CA3 and hilus fasciae dentatae region and the whole hippocampal formation. Concluding from the present results there are obvious discrepancies between the quantitative and histochemical data of the zinc distribution in the rat brain.

Aging↗
PubMed1983

Recovery of salt appetite after lateral hypothalamic lesions: effects of preoperative salt drive and salt intake experiences.

This study presents further observations on the effects of preoperative salt experiences on salt appetite following lesions of the lateral hypothalamus. The results confirmed earlier findings that preoperative salt experiences can protect the rat against the usual deficit in regulatory salt intake that follows such lesions. However, the results suggested that there may be no specific feature of the preoperative salt experience that is critical for the protective effect since both salt drive experience without concomitant salt intake experience and salt intake experience without concomitant salt drive experience were effective.

Animals↗
PubMed1983

Experimental hypo/hyperthyroidism in rats and the perinatal development of the hypothalamo-neurohypophysial system in comparison with the thyroid gland state and external features.

Neurophysin was detected immunohistochemically in the hypothalamo-neurohypophysial system of Wistar rats not before fetal day 18. Formerly, neurophysin was identified on day 16 of intrauterine life using another breeding stock of Wistar rats, but the same immunohistochemical reagents. In pregnant rats, experimentally induced hypo/hyperthyroidism beginning with day 13 of gestation failed to show any evident influence on the first appearance of immunohistochemically detectable neurophysin during the fetal development. Otherwise, significant effects on fetal body growth and other external features as well as the fetal thyroid state and histochemically demonstrable thyroid peroxidase activity were shown. The influence of thiamazol on the fetal thyroid peroxidase points out a primary effect and indicates the permeability of the placenta to this antithyroid drug.

Animals↗
PubMed1983

[Mondor's disease of the female breast].

This report is based on eight patients with Mondor's syndrome. Its main clinical findings is linear retraction of breast skin probably due to thrombophlebitis or lymphangitis. The final diagnosis of Mondor's syndrome implies exclusion of breast cancer by mammography. A differential diagnosis of this entity is discussed.

Adult↗
PubMed1983

Nuclear magnetic resonance characteristics of fresh and fixed tissue: the effect of elapsed time.

The nuclear magnetic resonance relaxation times T1 and T2 of liver and spleen from freshly euthanized rats were measured over 48 hours for samples treated with normal saline, fixed with 70% ethanol, neutral buffered formalin, or 10% formalin, or left untreated. The initial values of T1 and T2 for both tissues agreed with previous determinations. For untreated tissues of both liver and spleen, T1 was stable for 6 hours and T2 was stable for 48 hours. For fixed tissues, T1 was stable for 0.5 hours, but T2 changed in 0.5 hours.

Animals↗
PubMed1983

[Glutamate as a transmitter in the CNS and its presumed significance in the pathogenesis of cerebral seizure forms--recent aspects].

Glutamate is believed to be quantitatively the most outstanding of the excitatory transmitters in the CNS. Certain conformationally related analogues, e. g. kainate, N-methyl-D-aspartate, ibotenate, and homocysteate, act as glutamate agonists. The local or systemic administration of these "excitotoxic" compounds induces epileptiform activity pointing out new and deeper insights into the epileptic process. Additionally, the glutamate transmitter hypothesis is expected to give a chance of a causal comprehension for choreatic processes as well as for the mode of action of anticonvulsant and antispastic agents.

Brain↗
PubMed1983

[Mammographic changes in the partially resected and irradiated breast].

Thirtyseven patients with breast cancer stage T1 have been treated by tumorectomy or quadrantectomy and radiation therapy. Mammographic changes as skin thickening and parenchyme reaction were described and put in correlation between the end of treatment and mammography controls. Differential diagnostic problems are discussed.

Adult↗
PubMed1983

[Thyroiditis from the surgical viewpoint].

1296 Patients were treated for thyroid disorders in the Surgical Clinic of the University of Graz between 1975 and 1981. In 3.5% thyroiditis was diagnosed, 75% struma lymphomatosa Hashimoto and 25% subacute thyroiditis de Quervain. 75% of all cases were classified only by histological postoperative examination. Suspected malignancy leads in most cases to operative treatment, but there are also indications because of the inflammatory lesion. We do not believe that thyroiditis should be treated surgically as thyroid carcinoma, neither provides the low incidence between carcinoma and thyroid inflammation any radicality for preventing malignant disorders.

Adult↗
PubMed1983

Effect of retinoic acid on the synthesis of glycoproteins of mouse skin tumors during progression from promoted skin through papillomas to carcinomas.

Papillomas and carcinomas were induced on the skin of mice by initiation with dimethylbenzanthracene, followed by promotion with 12-O-tetradecanoylphorbol-13-acetate. Retinoic acid was applied topically, either chronically, throughout the promotion period, or acutely, to the papillomas or carcinomas. All tumor types were verified histologically. Tumor tissue was incubated with labeled glucosamine and labeled glycoproteins released into media were fractionated on DEAE-Sephadex. For papillomas, one peak (eluted with 0.17 M NaCl) appeared and another (0.40 M) all but disappeared as a result of retinoic acid treatment. Carcinomas also showed the 0.40 M peak released by papillomas, which was also suppressed by retinoic acid. Carcinomas released a 0.26 M peak instead of the 0.17 M peak in response to the retinoid. All three peaks yielded single, symmetrical peaks on gel filtration columns. They were all resistant to mild alkaline hydrolysis. Labeling experiments revealed the presence also of mannose, galactose, and traces of fucose in all three glycoproteins. The 0.17 and 0.26 M peaks were bound by concanavalin A-Sepharose columns, the 0.40 M peak was not. Molecular weights, as determined by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, were approximately 80,000 and 105,000 (0.17 M peak), 67,000 (0.26 M peak), 70,000 and 80,000 (0.4 M peak).

Animals↗
PubMed1982

[Menghini needle biopsy (MNB). A valuable aid in the diagnosis of parotid tumors].

At the University Ear, Nose, and Throat Clinic, Graz, the Menghini needle biopsy has been used in the diagnosis of parotid tumors for the last 12 years. In this kind of biopsy a tissue cylinder is obtained, which permits an exact histologic diagnosis. The Menghini needle biopsy can be easily performed. There is only little danger of injuring the facial nerve. The examination of 175 parotid tumors at our hospital has proved that the diagnosis was correct in 85% of the cases. Since the introduction of the Menghini needle biopsy, no increase in the relapse frequency has been found.

Biopsy, Needle↗
PubMed1982

Colonoscopic diagnosis and management of rectal bleeding.

The use of the colonoscope to evaluate the cause of rectal bleeding in a series of 2200 patients has been reviewed. The most common cause of bleeding in this series was found to be neoplastic polyps, which were present in 723 patients (32 per cent). Colonic carcinoma was detected as the source of the bleeding in 425 cases (19 per cent). Although a large number of barium enema films were false negatives, the patients reviewed are a highly select group. It is still believed that barium enema studies and colonoscopy are complementary rather than competitive procedures. Their continued combined use greatly enhances diagnostic accuracy. Various other causes of colonic bleeding, including inflammatory bowel disease, arteriovenous malformations, endometriosis, ovarian carcinoma, ischemic colitis, and radiation colitis, have been discussed and their endoscopic appearance described. Of particular significance is the coexistence of internal hemorrhoids or diverticular disease and neoplastic colonic lesions. Barium enema films and sigmoidoscopy have been frequently described as the twin pillars of diagnosis in the detection of colonic pathology. Colonoscopy, as the third pillar of diagnosis, should be an integral part of the evaluation of patients with rectal bleeding.

Colitis↗