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Biomedical subjects

G Wiedemann

Publications and source records attributed to G Wiedemann.

At least 91 records · Page 5Linked to original sources
PubMed1984

[Comparative study of oxygen tension in arterial blood and arterialized capillary blood in relation to the oxygen content of inspired air in healthy newborn infants].

The values of oxygen tension of arterial blood were compared with those of arterialized capillary blood in 65 healthy newborns. The latter ones always had a significantly lower level than the arterial ones. A sufficient correlation between paired values could be stated only under conditions of normal room air. With increasing FiO2 (0.4, 0.6, 1.0) the capillary oxygen tension remains behind the arterial one. Giving pure oxygen the capillary tension is nearly half of the arterial value.

Capillaries↗
PubMed1983

Controlled trial of ancrod in ischemic stroke.

In a randomized, single-blind study, 30 patients with acute ischemic stroke were treated with either low-molecular weight dextran and mannitol alone (group A, mean age, 63.3 +/- 11.8 years, n = 15) or in combination with the viper venom enzyme ancrod (group B, mean age, 67.9 +/- 7.6 years, n = 15). Lowering of plasma fibrinogen levels to 100-130 mg/dL with ancrod resulted in a significant reduction of the apparent blood viscosity, ie, of 37% at a shear rate of 0.03 s-1, compared with only 7% in group A. Fibrin degradation products increased considerably from 3.1 +/- 0.4 to 154.3 +/- 31.6 mg/L on day 3, while plasminogen decreased from 98.2% +/- 2.0% to 79.8% +/- 2.9% in group B. Global coagulation and platelet function tests were not influenced by either treatment. Neurological score improved by 1.1 arbitrary units (AU) in group A and by 2.6 AU in group B. Five patients in group A and two in group B died during the first two weeks. This preliminary study indicated a slightly better outcome in the ancrod treated patients. The beneficial effect may be due to the anticoagulative and fibrinolytic activity of ancrod rather than its effect on blood viscosity.

Ancrod↗