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Biomedical subjects

G Wessel

Publications and source records attributed to G Wessel.

At least 73 records · Page 4Linked to original sources
PubMed1979

[Joint involvement].

Explore the source record for details and available documents.

Arthritis, Rheumatoid↗
PubMed1978

[Results after fracture of the os calcis (author's transl)].

A double study over a period of 40 years was undertaken--from 1935 to 1954 in Berlin and from 1955 to 1976 in Salzgitter--including a total of 393 fractures of the os calcis. The results of different types of treatment are presented. It is the type and severity of the fractures, not the way of treatment which determines the outcome. 161 patients have been followed clinically and radiologically at least 5 years after fracture of the os calcis. Third degree fractures were objectively and subjectively less favourable regardless of therapy. Active surgical treatment should be post-poned and consist in fusion of the subtalar joint.

Adolescent↗
PubMed1977

[Intra-articular therapy of chronic arthritides].

The intraarticular therapy with the aim of the direct influence on the pathologically changed synovial membrane increasingly gains significance. On the basis of own results as well as literary data the present possibilities of the local treatment of chronic arthritides are described. After discussion of the advantages and disadvantages of the individual usable preparations a scheme of therapy elaborated for the use of local therapeutics in chronic synovialitis is described. Exact indications for the use of the intraarticular as well as operative methods for therapy of chronic synovialitis must still be established.

Adrenal Cortex Hormones↗
PubMed1977

[Laboratory diagnosis in rheumatology].

The laboratory diagnostics essentially contributed to the pathogenetic clarification of rheumatological problems and gives multifarious support to the rheumatologist in differential and activity diagnostics and thus also decisively contributes to early diagnostics and therapy. When the acute-phase-reactions serve for the differentiation of inflammatory-rheumatic diseases and degenerative diseases and for the establishment of the degree of activity, so the ASR further the diagnostic ascertainment of a rheumatic fever, the agglutination tests for proving the rheumatoid factor further the differential diagnosis of the rheumatoid arthritis, the LE-phenomenon and the ANF further the differential diagnosis of the LEV, the proof of cardiac auto-antibodies essentially furthers the diagnostics of carditis, the increase of uric acid the early recognition of gout, the synovial diagnostics at length became necessary for the clarification of clinically unclear mon- or oligoarthritides and the determination of the local activity for the observation and judgment of the course. Notwithstanding the primate of the clinic without an effective laboratory diagnostics a modern rheumatology can no more be performed nowadays.

Antibodies, Antinuclear↗
PubMed1977

Chemical synovectomy with Varicocid in rheumatoid arthritis--further results.

Varicoid was administered to 170 patients with rheumatoid arthritis, to 11 patients with a diagnostically uncertain monarthritis, to 12 patients with exudative gonarthrosis and also to 4 patients with lupus erythematodes visceralis. A total of 262 joints were treated. The short-term results, which were evaluated 4 weeks after the administration of Varicocid, revealed improvement is 95% of the patients. After 12 months, 46% of the patients were found to be free from symptoms within the area of the treated joint, and 33% of the patients showed a considerable improvement. An objectively evident improvement was found in 35 out of 40 patients with rheumatoid arthritis followed up over a period of 3 years. Comparable results after treatment with Varicocid were also obtained in patients suffering from any one of the above-mentioned rheumatic diseases. A new inflammation activity/function index for the evaluation of the local joint therapy has been used. The first investigations both of function and of morphology of the synovial membrane treated with Varicocid are reported. In our opinion, chemical synovectomy with Varicocid fills a gap in the therapy of the rheumatoid arthritis. The essential value of this type of therapy is the absence of toxicity, a temporary increase in local reactions only, and also a continuous improvement, especially in early cases.

Arthritis↗
PubMed1976

[Contribution to the clinical picture of Wegener's granulomatosis].

On the basis of 5 casuistics of Wegener's granulomatosis the author deals with the difficulties of the diagnosis and differential diagnosis, whereby above all is referred to the preculiarities of the cases and the malinterpretation of the diagnoses on admission to the hospital.

Adult↗
PubMed1975

[Heridity of progressive chronic polyarthritis - study of the course].

In an analytic epidemiological study 30 relations of patients with progressive chronic polyarthritis with positive rheumatoid factor and 127 relations with negative rheumatoid factor were after-examined concerning their clinical and serological behaviour 6 years after the primary recognition with the aim of an evidence concerning the hypothesis of an hereditary causal factor in progressive chronic polyarthritis. It was revealed that only in 14 of 30 persons with positive primary rheumatoid factor the rheumatoid factor could further be proved, on the other hand 14 relations who had at first a negative rheumatoid factor now, however, reacted with a positive rheumatoid factor. It could be confirmed, that the seropositive forms of the progressive chronic polyarthritis have a stronger hereditary trend to the formation of the rheumatoid factor than the seronegativeones and that after the 50th year of life there exists a significant persistence of the seropositivity. In the group of relations who were seropositive 6 years ago developed a definitive and probable progressive chronic polyarthritis each as well as a further probable progressive chronic polyarthritis in the group of relations who became seropositive only in the period of observation. On account of the changing seropositivity and the only rare appearance of a progressive chronic polyarthritis on the basis of this investigation of hypothesis of the rheumatoid factor as first (premorbid) symptom of a progressive chronic polyarthritis is to be refused.

Adult↗
PubMed1975

[The clinical value of the hydroxyproline excretion in 24 hour urine compared to other laboratory diagnostic parameters in ankylopoietic spondylarthritis].

Hydroxyproline provable in the urine of man is regarded as indicator of the collagen metabolism. In 40 patients with ankylopoietic spondylarthritis the excretion of hydroxyproline in the 24-hour-urine was determined with the help of Stegemann's method. With 27.5 mg for the total hydroxyproline and 2.6 mg for the free hydroxyproline in the group of patients statistically significantly higher values were established than in a comparative group of 52 persons (20.1 or 0.6 mg, respectively). In patients with higher activity of the process (anamnestically, clinically) the excretions were larger than in patients with lower activity. That in this reflects also the temporary factor is to be concluded from the higher excretion rate in patients with a shorter duration of the disease and a low rate with a longer course. In comparison to the insignificant diagnostic relevancy of other acute-phase-reactions (BSR, CRP, number of leukozytes, blood protein fractions) from this results the conclusion that the determination of hydroxyproline may be used for the diagnostics of activity and also for the early diagnostics. By the temporary and technical-material expenditure, however, its use is limited in the routine practice.

Adult↗