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Biomedical subjects

G Wessel

Publications and source records attributed to G Wessel.

At least 37 records · Page 2Linked to original sources
PubMed1987

The influence of selected urinary constituents on the adhesion process of Escherichia coli to human uroepithelial cells.

In the pathogenesis of infectious diseases, great importance is attached to the problem of adhesion of bacteria to cells. In 100 urine specimens from normal test persons, patients with infections of the lower urinary tract, with chronic pyelonephritis and glomerulonephritis were studied. The adhesion of strains of Escherichia coli to human uroepithelial cells depended on the concentration of single urinary factors. While increased concentrations of urea and creatinine favored the adhesion process, a statistically significant negative influence was found with regard to potassium, immunoglobulins and pH value. Considering the multifactorial effects of the urinary constituents, we found in a multivariate comparison that none of the studied physiological features alone exerts a fundamental influence upon adhesion, but in their entirety they determine the environmental conditions for the adhesion of bacteria to cells in the urine.

Adult↗
PubMed1987

[Significance of parathyroid hormone (PTH) within the scope of central nervous system disorders in hemodialysis patients].

The role of PTH as possible uraemic toxin within the scope of disturbances of the central nervous system (progressive dialysis encephalopathy, PDE) was investigated in 88 patients undergoing haemodialysis. A radioimmunoassay covering the C-terminal PTH fragment was used. Patients undergoing haemodialysis with a PDE showed the highest values with 2,015.4 +/- 457.9 pg/ml, and also in the preclinical stage of a PDE the PTH values with 1,845.7 +/- 663.1 pg/ml lay significantly above those ones of the patients undergoing haemodialysis without PDE (794.8 +/- 364.7 pg/ml). The findings speak for the importance of PTH in the development of complications of the central nervous system within the scope of the uraemia syndrome.

Adult↗
PubMed1986

Medium-term trends in the occurrence of rheumatic diseases in European countries. Results of an inquiry on statistical data.

An inquiry based on statistical data concerning rheumatic diseases in seven European countries was performed. The data reported were based on the ICD (8th revision, 1965). The time of reference was the period 1968-78. The countries concerned (Czechoslovakia, Finland, France, the GDR, Poland, Sweden and the United Kingdom) reported data on the following 'measures of frequency': rates of hospital discharge; rates of spells of sickness and incapacity for work; incidences of disability pension due to rheumatic disorders. The main results are threefold: The social importance of rheumatic diseases has been increasing in several European countries in the late 1960s and 1970s, though the situation differs from one country to another. There is sufficient evidence to assume a true increase in the occurrence of clinical symptoms among persons afflicted with 'degenerative arthropathy', i.e. osteoarthrosis and vertebrogenic pain. The increasing social importance of 'degenerative arthropathy' ought to stimulate a process of rethinking of the traditionally established priorities in rheumatological research and practice.

Absenteeism↗
PubMed1985

Myocardial bioptic findings in correlation with TL-201 imaging and hemodynamic parameters in patients with latent cardiomyopathies suspected of having myocarditis.

Sixty-eight patients (24 males, 44 females, mean age 37.2 years) belonging to NYHA classes I and II were investigated. All patients had a nondilated ventricle as well as hemodynamic criteria of "latent cardiomyopathy." In 78% of the patients, a high susceptibility to infection, frequent angina, or possible myocarditis were found. In 75.5%, the mean pulmonary artery pressure was abnormal. T1-201 scintigraphy revealed perfusion defects in 78%. Dyskinesia or hypokinesia were found in 52%. The left ventricular ejection fraction was normal in 74%. On biopsy, pathologic findings were detected in 60.9% of patients with a high frequency of hypertrophy and fibrosis (50%). In two patients, lymphocytic infiltrates were found. Immunohistologically, deposits of complement, IgG, IgM, and gammaglobulin, mainly in the sarcolemma, could be identified in 19.1% of cases. The myocardium was normal in 39.1%; insufficient material was found in 5.9% of patients. Morphologic, scintigraphic, and hemodynamic findings could not be correlated but the combination of two pathologic parameters permitted diagnosis. Biopsy was the most effective diagnostic method in myocarditis.

Adolescent↗
PubMed1985

[Vitamin A status of patients with chronic renal failure in relation to renal osteodystrophy].

In patients with chronic renal insufficiency and dialysis patients as well as in normal persons determinations of vitamin A in the serum and in the bone were performed and related to the parameters of the bone metabolism and to the histomorphometric investigation of the bone. The vitamin A serum levels were significantly increased in the two groups of patients, however, did not show any differences between the patients with an osteoidosis or the combination of osteoidosis and fibroosteoclasia. There were no correlations to calcium, phosphorus, PTH and to the alkaline phosphatase as well as to the individual histomorphometric data. The vitamin A content of the bone was low and did not show any differences to the normal persons. On the other hand, there were significant relations between the parathormone and the parameters of the regeneration and the absorption of the bones. An additional influence of vitamin A on the bone disturbance, eventually by the activation of the osteoclasts cannot be excluded.

Adult↗
PubMed1984

[The effect of low-dose heparin therapy on patients in an internal medicine intensive care unit].

It is reported on 191 patients of an intensive care unit, in whom for the purpose of the prophylaxis of thromboses and thromboembolic complications a low-dose heparinisation was carried out. For comparison served the documents of 137 patients who were admitted to the same department for homogeneous reasons but had not been treated prophylactically with anticoagulants. In no case more massive haemorrhages developed which might have compelled us to interrupt the therapy. In spite of the low-dose heparinisation 4 pulmonary embolisms as well as thromboses of the abdominal aorta, the radial artery and the coronary arteries were the result; they were confirmed autoptically . Thus the low dose heparinisation does not represent a sufficient protection against the thromboembolic complications for patients with internal diseases who are confined to bed. The demand is made to establish the individual need of heparin and to adjust the heparin dose according to this.

Aged↗
PubMed1984

[Comparative studies on the bioavailability of various drug forms of phenylbutazone and clofezone (Perclusone)].

The bioavailability (BA) of phenylbutazone and clofezone preparations had been determined in patients suffering from rheumatic diseases. Clofezone is a compound preparation of phenylbutazone and clofexamide, with which the phenylbutazone portion amounts to 49%. In spite of an equivalent dosage (0.4 g phenylbutazone or 0.8 g clofezone, resp.) significant differences in the phenylbutazone-serum level profile had partly been stated after the application of different kinds of the preparation of both the drugs. The oral administrations (phenylbutazone dragées, Perclusone capsules) resulted in a prompt resorption; the plateau values of the phenylbutazone concentration in serum had already been completed after 2-3 h. The resorption from suppositories was decreased. The serum level maximum with phenylbutazone suppositories occurred after 6 h, with Perclusone suppositories after 24 h only. Compared to the phenylbutazone i.v. injection, the phenylbutazone dragées proved a complete substance uptake into the systemic circulation, whereas a relative BA of 65% has been determined for Perclusone capsules. The BA of the phenylbutazone suppositories amounted to 67%, those of the Perclusone suppositories to 41%.

Administration, Oral↗
PubMed1982

[New method of isolating components of immune complexes, using the example of rheumatoid arthritis].

Immune complexes were precipitated under defined conditions using polyethleneglycol. The precipitation was subjected to the first electrophoresis under nondecomposed conditions for immune complexes. In this way IgG can essentially be separated from the immune complexes which remain in the place where they were applied. In a second electrophoresis, the broken immune complexes were fractionated into IgM and IgG bands. These were analysed for antibody activity by means of hemagglutination and immunofluorescent methods. In serum of 20 rheumatoid arthritis patients, we could detect in the IgM fraction of the immune complexes the rheumatoid factor, an antinuclear antibody, and a new unknown antibody directed against cell plasma membranes of human muscle cells and endothelial cells. The importance of this new antibody in the pathogenesis was discussed.

Antigen-Antibody Complex↗