Biomedical subjects
Publications and source records attributed to G Werner.
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It is reported on a left-atrial myxoma in a 20-year-old patient with atypical symptomatology of the mitral stenosis, unspecific general symptoms and lethally finishing embolisms and on the basis of the course the problems of the differential diagnosis and of the complications are shown.
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The effects of atropine, propranolol, phentolamine, and orciprenaline on the minute-rhythmic fluctuations of the heart rate were investigated in urethane-anaesthetized mice. These drugs influenced the parameters of the minute rhythm (amplitude, length of period). However, the rhythm was not suppressed over any length of time. After blocking the vagus with atropine, the rhythm was maintained unchanged. In the other cases, the rhythm was not demonstrable only during the transition to a new level of heart rate. Immediately after the injection of each drug, the amplitude of the minute rhythm was very low for the most part but gradually increased in size again. After the injection of each drug, there existed the same correlations between the length of period of the fluctuations of heart rate and the respective mean rate (i.e., the arithmetic mean of both extreme values of a period) as after the injection of urethane alone. The same rhythms as are characteristic for the respective ranges of heart rate after the injection of urethane alone were also observed. The possible central and peripheral mechanism of origin of this minute rhythm are discussed. Since neither the blockade of the vagus nor the blockade of the sympathetic innervation could suppress the occurrence of periodic fluctuations of the heart rate for a long time, a peripheral origin of this minute rhythm may be assumed. Moreover, because there are no indications for a direct influence of urethane on the cardiac pacemaker, urethane might be supposed to produce the conditions for a pronounced appearance of the latently existing autogenic rhythm of the heart by acting on the central nervous system. Therefore, the visceral nervous system would be responsible only for the modification of the parameters (amplitude, length of period) of this rhythm.
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The typical reconstruction model of an unstimulated human platelet is presented. It shows a strict spatial order of organelles and enodmembrane systems. The surface-connected vesicle system is predominantly found in the periphery. The dense tubules constitute a continuous, interconnected system found just under the surface of the platelet. They are particularly pronounced in the vicinity of the marginal microtubules. All organelles are in contact with the dense tubular system (DTS). Granules, vesicles and plasmalemma fuse into the tubules. The platelet organelles are centrally located. Lysosomal granules are primarily shperical and all of them contain a nucleoid. This speaks in favor of a single type of storage organelle in the platelet. The dense bodies and their remnants (large, solitary vesicles) are not joined by the other endomembrane systems, as in the case of the granules. A particular pathways for the release of substances from these organelles is now morphologically plausible. Mitochondria are small, solitary granules surrounded by dense tubules. Owing to its unique position with the platelet, the DTS's role as a mediating and regulatory structure is discussed.
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This paper reports the major findings of a questionnaire sent to the 708 U. S. and Canadian institutions which were using the National Library of Medicine's search services as of November 1977. Development of the National Library of Medicine (NLM) on-line network is traced characterizes type of institution, use of NLM and non-NLM data bases, operational service patterns, staffing levels, fee-for-service policies, and perceived impact.
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From the date of injury tetraplegics with spinal cord lesions of C4 and above are faced with unparalleled social and psychological adjustment. The individual will be involved in a process of re-establishing his identity by learning to develop and adapt his only remaining resources, his mind and his ability to communicate. This patient population is absolutely dependent in all aspects of meeting basic needs during the initial stages of the injury. If we attempt to return the patient to an active role in society, the rehabilitation team must be aware of the dynamics by which the patient achieves control of both himself and his environment. He will undergo a marked regression of his physical and emotional being and will face the turmoil of realigning ego parameters. The focal point of patient, family and staff interaction is the months of rehabilitation, where the team deals with the problem of social reintegration. Family involvement is essential from the beginning and reaches a high point at discharge and home planning. The scope of the paper will be to trace the psycho-social development of the patient with cervical lesion of C4 and above through the initial, rehabilitation and discharge phases of the injury. Our aim is to develop sufficient insight to the problems facing our patient population that we may aid in their search for meaningful lives.
The clinical picture of electrolyte-losing villous tumours localized in the rectum or colon is represented by own observations and the literature. Diagnostic errors arising from disturbances of water and electrolyte balance are emphasized. In order to find out the optimal therapy, classification of the tumour according to clinical criteria is recommended.
After operative procedures of greater extent stress ulceration in the stomach or duodenum can arise, sometimes perforating the wall. Unfortunately, such perforations are not diagnosed in time. In a postoperative breakdown of the circulation, which otherwise cannot be explained, stress ulceration and perforation should be taken into consideration.