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Biomedical subjects

G Weiler

Publications and source records attributed to G Weiler.

At least 55 records · Page 3Linked to original sources
PubMed1987

[Hemosiderin findings in the liver, spleen and lung in newborn infants and infants].

The content and distribution of hemosiderin in the liver, spleen and lungs of stillborn children, newborns and infants were determined histologically by Perl's method (Prussian blue reaction). We describe a study of 59 deaths up to the age of 2 years. The hemosiderin content depends on age and decreases with increasing age. No relevant differences were found in cases of sudden infant death syndrome (SIDS). In the liver hemosiderin is localized preponderantly in the periphery of the lobules. The spleen shows a diffuse siderosis of the red pulp. Minimal intrapleural, septal and perivasal depositions of hemosiderin can be found in the lung tissue. The significance of these findings is discussed.

Female↗
PubMed1987

[Lipomatosis cordis as a cause of ventricular perforation in implantation of a pacemaker probe].

A case report is given on lethal perforation of the right ventricle during emergency implantation of a pacemaker probe. The forensic autopsy revealed extensive lipomatous infiltration of the right ventricle in the rupture area. Lethal complications occur occasionally in spite of the standardization of implantation techniques, especially as a result of reanimation attempts. Such cases are discussed with regard to the forensic aspects with reference to the literature. Lipomatosis cordis as "locus minoris resistentiae" has special significance for ventricular perforation.

Aged↗
PubMed1986

[New diagnostic possibilities of postmortam coronary angiography by digital subtraction angiography].

Postmortal digital subtraction angiography permits vessels filled with a contrast agent to be visualized selectively in a video film shot and the contrast agent flow to be observed directly in the coronary arteries. Compared to conventional static methods of postmortal coronary angiography, the judgment on the hemodynamic effects of stenosis and occlusion, as well as of collaterals and anastomosis, will be improved and therefore the diagnosis of acute coronary death. The diagnostic possibilities and advantages of DSA are demonstrated in two cases.

Adult↗
PubMed1986

[A rare cause of 2 unclear fatalities: undiagnosed acute and chronic amebiasis].

Two cases are reported of unexpected and unclarified death caused by an infection with Entamoeba histolytica. The first case concerned a German whose disease was not diagnosed during the asymptomatic phase (2 years' duration) or in the acute phase during the last 3 weeks before death. This is typical of the disease. In the final phase, he developed a hepatic abscess. Death occurred as a consequence of bilateral apoplexia in the adrenal glands. In the second case a Turk fell ill with gastralgia and diarrhea. Developing hepatic insufficiency with comsumptive coagulopathy, he died after 6 days. Intoxication and/or intolerance of fructose were assumed as tentative diagnoses. These two cases show clearly that even outside an endemic area, one has to reckon with the possibility of amebiasis.

Adrenal Glands↗
PubMed1986

[Comparative histologic and hormonal studies of the thyroid gland with special reference to sudden infant death (SIDS)].

In 53 cases of death - including 12 cases of sudden infant death syndrome (SIDS) - where blood samples could be taken within 18 h postmortem, the thyroxines T4, FT4, T3 and FT3 were determined (ELISA and RIA). These hormone values were compared with the corresponding histological thyroid findings in 43 cases (11 SIDS, 32 controls). Nearly identical T4 and FT4 mean values were found in both groups which were within the norms. In contrast to the average values of the control group, the T3 and FT3 concentrations of the SIDS group showed an increase of 3.7-fold and 1.9-fold. Accordingly, histological examination of the SIDS group showed highly activated and extensively released follicles whereas normal colloidal-containing follicle structures were observed in nearly all control cases. The present findings indicate that neither postmortem T4 T3 conversion nor intensified agonal hormone secretion is likely to be the only cause of the increasing T3 and FT3 values. In SIDS cases chronic or recurring chronic stress situations are supposed to be the cause for the hormonal and histological thyroid findings. Some differential diagnoses are discussed. Within 18 h after death, increased concentrations of T3 and FT3, together with simultaneous colloid release, represent a diagnosis of SIDS.

Adolescent↗
PubMed1986

[Progressive muscular dystrophy of the Duchenne type].

A case of sudden death is reported that occurred as a result of Duchenne type progressive muscular dystrophy with extreme myogenic changes. These changes consisted of extensive muscular lipomatous transformation, typical of the advanced stage of the disease. The heart showed myocardial fibrosis, the respiratory system acute tracheobronchitis with early signs of bronchopneumonia. The pattern of distribution of the changes in the musculature is discussed with regard to the sudden death as well as to the possibility that medical malpractice may have occurred.

Adult↗
PubMed1986

[Putrefaction-induced changes in the concentration and temporal detectibility of carbon monoxide in cadaveric blood samples].

Eighty-five blood samples with COHb concentrations of 40% and 70% were allowed to putrefy in order to measure the time-dependent changes in COHb values. The samples not hermetically closed had been stored at 6 degrees C and 20 degrees C. GC and photometric methods were applied. Two graphs show that after 15 days (40% COHb) and after 30 days (70% COHb), the COHb concentrations decreased to half at 20 degrees C. Corresponding decreases at a storage at 6 degrees C could be observed after 1 year. Further investigations excluded the formation of new CO.

Carbon Monoxide Poisoning↗
PubMed1985

[Histomorphologic lung findings in long-term artificial respiration with special reference to extreme continuous artificial respiration using pure oxygen].

The respirator lung is characterized histologically in the first exudative phase by capillary congestion, intra-alveolary edema, hyaline membranes and in most cases by concomitant inflammatory alterations. In the following irreversible phase, fibrous organization processes dominate and show a variable tendency towards pulmonary fibrosis. In 27 cases with long-term artificial respiration from 4 days to 12 weeks, mainly the proliferative alterations were investigated. In 18 cases, the histopathological findings indicated fibrosis of the alveolar septa with disseminated distribution. In 9 cases, focal fibrosis with obliterations of alveoli prevailed. The extent of pathological results in the lungs does not correlate with the duration of artificial respiration. In cases of artificial respiration with pure oxygen, there is a special toxic component, which is illustrated by a young woman with polytraumatism who was administered artificial respiration for 5 weeks with pure oxygen. She died from respiratory insufficiency with severe pulmonary fibrosis. As different pathogenetic factors may cause irreversible pulmonary fibrosis, histomorphological classification is difficult later and, moreover, forensic problems result.

Adolescent↗
PubMed1985

[Coronary muscle bridge and its relations to local coronary sclerosis, regional myocardial ischemia and coronary spasm. A morphometric study].

Morphometrical investigations on 35 coronary arteries with muscle bridges prove their local protection from atherosclerosis. The average values of the intima thickness in the artery proximally situated to the coronary muscle bridge are 406.6 microns, in the region of the bridge 66.3 microns and distal to the bridge 103.4 microns. The correspondent values of the media are not significant. Stenoses situated proximally to the coronary muscle bridges are almost completely of the eccentric kind and must be considered as potentially dynamic stenoses. The morphological and angiographical findings in cases of coronary muscle bridges, together with clinical observations, indicate a connection between coronary muscle bridges and coronary spasm, at least under pathophysiological conditions.

Adolescent↗
PubMed1984

[Detectability of poisons in paraffin-embedded organ parts].

The detectability of metals and drugs in histological organ parts embedded in paraffin was tested in 24 cases, which had been analyzed before. The liver, kidney and brain parts were separated from the paraffin by heating the paraffin up to 110 degrees C and were homogenized by means of Ultra-Turrax blendor and ultrasound. Analysis was realized using gas chromatography, atomic absorption and mass spectrometry. Only 1.5%-4% of the original quantities of metals (As, Tl, Hg) was found in the embedded organs. Drugs could not be detected except for a low percentage of phenobarbital (2 cases) and bromine (3 cases). Reliable estimations cannot be made about the concentrations in the organs before the embedding procedure.

Arsenic Poisoning↗
PubMed1984

[Histologic thyroid gland findings in the newborn infant and infant, with special reference to sudden infant death].

The morphological picture of the thyroid gland, the only endocrine organ with a follicle structure, allows a limited conclusion to be drawn with respect to the functional state in spite of any physiological variability. The thyroid of the newborn shows total colloid release and collapse of the follicles. The regular structure of the thyroid will be rebuilt within several weeks after birth. Total colloid absorption can be found in cases of stress-activated thyroids as well as in cases of death due to freezing. A histological examination was done on 88 thyroids of fetuses, newborns and infants. About 70% of the results on 27 cases of sudden infant death syndrome (SIDS) may be interpreted as a morphological correlate of a premortal chronic or recurrent stress reaction. The value of these results is discussed.

Child, Preschool↗