Search PubMed⌕ Search

Biomedical subjects

G Volden

Publications and source records attributed to G Volden.

At least 109 records · Page 6Linked to original sources
PubMed1979

Photosensitivity and cutaneous acid hydrolases in porphyria cutanea tarda.

In the present study the participation of lysosomal enzymes in the primary photosensitizing process in the skin of porphyric patients were investigated. Cutaneous photosensitivity reactions were produced in patients with porphyria cutanea tarda by irradiation with near UV light and also to a lesser degree with visible light. The reactions occurred almost exclusively in patients with urinary uroporphyrin excretion exceeding 900 nmol/24 h and preceeded any noticeable increase of lysosomal enzyme activity by several hours. These results indicate that lysosomal enzymes are not primarily involved in the photosensitizing reaction in porphyric patients but that they participate in the cutaneous inflammatory process in porphyric skin at a later stage.

Acid Phosphatase↗
PubMed1979

Mycosis fungoides plaque stage treated with topical nitrogen mustard with and without attempts at tolerance induction: report from the Scandinavian mycosis fungoides study group.

The Scandinavian Mycosis Fungoides Study Group has treated 21 patients with mycosis fungoides in plaque stages with topical, whole-body application of nitrogen mustard, 20 mg in 40 ml water per square metre. Ten patients were treated after previous attempts at intravenous tolerance induction ad modum van Scott & Kalmanson and eleven without. Complete remission was initially achieved in 10 patients and partial remission in 9 patients. Contact dermatitis to nitrogen mustard developed in 2/10 after tolerance induction and in 1/11 without tolerance induction. It is concluded that topical, whole-body application of nitrogen mustard gives high remission rates. In this series, however, many relapses occurred, due to inadequacy of the maintenance treatment. Tolerance induction has not been found of any value.

Administration, Topical↗
PubMed1979

Epipodophyllotoxin (VP-16-213) in mycosis fungoides: A report from the Scandinavian mycosis fungoides study group.

Epipodophyllotoxin (VP-16-213) was administered to 9 patients with mycosis fungoides in various stages, most of them in the advanced tumour stage. In 4 of the patients VP-16 was combined with cyclophosphamide. VP-16 alone or in combination with cyclophosphamide was capable of inducing remission initially in all cases, complete in 2, partial in 3 and improvement to a lesser degree in the remaining 5 patients, but it was unable to maintain the remission. The induced remission has to be upheld by other agents, possibly added to VP-16.

Adult↗
PubMed1979

Occurrence of immunoglobulins and complement in the skin of patients undergoing topical treatment of mycosis fungoides.

Deposits of immunoglobulins (IgG, IgA and IgM) and complement were occasionally found in lesional skin of mycosis fungoides patients. However, after complete remission of the skin lesions, deposits of immunoglobulins and complement were found, corresponding to previous infiltrates or tumours, in about half of the patients. These deposits appeared as globular bodies in the upper part of the dermis closely connected with the basement membrane.

Complement System Proteins↗
PubMed1978

Acid hydrolases in blister fluid. 4. Influence of ultraviolet radiation.

Large, dose-related increases have been demonstrated in the activity of lysosomal hydrolases in the fluid of experimental suction blisters raised on skin previously irradiated with UVR-B. These increases appear after a latent period of 11--18 h, and the pattern of changes shows an extremely good correlation with the hydrolase profile of epidermis. These observations offer strong support for the concept that lysosomes participated in the sequence of events following UV irradiation, but seem to rule out the lysosome as the initial target for UVR.

Adolescent↗
PubMed1978

Acid hydrolases in blister fluid. I. Characterization and quantification of acid phosphatase.

Acid phosphatase has been characterized and quantified in human suction blister fluid, interstitial fluid and serum. The acid phosphatases of suction blister fluid and serum showed differences in their pH activity curves, Michaelis-Menton constants, heat stabilities and sensitivities to inhibition by tartrate and fluoride. The behaviour of the interstitial fluid enzyme was intermediate between these two. The levels of activity in blister fluid and serum were very similar, both being more than twice that of interstitial fluid. These results suggest that the acid phosphatase activity in suction blister fluid is derived largely from the overlying epidermis rather than from serum.

Acid Phosphatase↗
PubMed1978

Acid hydrolases in blister fluid. II. Characterization and quantification of glycoside hydrolases.

Seven glycoside hydrolases have been investigated in suction blister fluid, interstitial fluid and in serum. Six of these have been characterized; no differences could be demonstrated between the corresponding enzymes from the various sources. The remaining enzyme (beta-glucosidase) was not found. Quantitative data suggest that 2 enzymes (beta-acetylglucosaminidase and beta-glucuronidase) diffuse freely from the epidermis into blister fluid, whereas 4 (alpha-glucosidase, alpha- and beta-galactosidase and alpha-mannosidase) are almost entirely retained in the roof of the bulla.

Blister↗
PubMed1978

Remissions of mycosis fungoides induced by nitrogen mustard (HN2). Topical treatment and hydration of tumours and plaques with HN2. Topical desensitization to HN2. A clinical and histopathological controlled study.

In this study 12 patients with mycosis fungoides were treated with whole body topical application of HN2. In addition 4 of these patients had gauzes moistened with the same HN2 solution placed upon plaques and tumours. 4 patients developed in allergic contact dermatitis, and this complication was overcome by percutaneous desensitizing in 3 of them. After starting hydration of plaques and tumours with HN2, the average time to obtain complete clinical remission was shorted from 4.4 to 2.5 months. A little later at the optimal histologic response, there was no or almost no cellular infiltration in 5 cases, while in 6 cases there was only a slight, unspecific, lymphocytic infiltrate in the dermis.

Administration, Topical↗
PubMed1977

[Mycosis fungoides].

Explore the source record for details and available documents.

Administration, Topical↗
PubMed1977

Absence of arylsulphatases A and B in suction blister fluid interstitial fluid and serum.

Suction blisters were raised on human skin. The blister fluid was collected for enzymic assay and the epidermis over the bullae was removed before further suction of interstitial fluid. Preliminary work indicated the presence of arylsulphatases A and B in epidermis, and the same assay procedure with 4-methylumbelliferyl sulphate as substrate was used. There appeared to be no enzymatic activity in blister fluid, interstitial fluid and serum.

Arylsulfatases↗