[The pigments of Lineus ruber (O. F. Müller) (Heteronemerta Lineidae)].
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Biomedical subjects
Publications and source records attributed to G Vernet.
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Melatonin, a well-known pineal substance implicated in conveying photoperiodic information in vertebrates, appears to be present as well in the eyes and brain of the nemertine worm: Lineus lacteus. The nyctohemeral rhythm was studied, too. The identification of melatonin in this new invertebrate species corroborates our hypothesis that it may be an evolutionarily conserved molecule, principally involved in the temporal transduction of photoperiodic information in all living organisms.
Metapramine (Timaxel) is a tricyclic antidepressant drug devoid of anticholinergic properties. As other psychotropic drugs, it may induce hyperthermia and several case-reports have been published. Agranulocytosis is an exceptional side-effect of this drug. Even if several cases have been reported to Pharmacovigilance structures in France, as far as we know there is no publication of this unwanted effect. The authors reported the case of an old woman who has presented two episodes of fever and asthenia. Blood formula was both times characterized by agranulocytosis without anemia nor thrombocytopenia. The accidental rechallenge of metapramine permitted to conclude to a causal relationship between these hematological events and metapramine intake.
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