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Biomedical subjects

G V Morozov

Publications and source records attributed to G V Morozov.

At least 37 records · Page 2Linked to original sources
PubMed1984

[Effect of vasopressin on long-term memory (psychophysiological and clinical aspects)].

In chronic alcoholic patients with reduced ability for memorizing, lysin-vasopressin (LVP) exerts an obvious positive effect upon the involuntary long-term memory. The effect is more obvious in tests demanding a semantic processing of information rather than the automatic memorizing. Under the LVP effect, an enhancement of the alpha-rhythm synchronization occurs in the EEG. The maximal "inhibitory" effect of the LVP occurs against background of desynchronization with an initial increased level of unspecific ascending influences. The LVP rises the upper limit of the response in the form of the EEG rhythms rearrangement, i. e. it increases the lability of cerebral structures. In conditioning therapy of chronic alcoholism the LVP increases the negative reflex to ethanol formed on the basis of apomorphine. The data obtained reveal an essential acceleration and increased durability of conditioning to ethanol as the result of the LVP use.

Adult↗
PubMed1980

[Effect of apomorphine on rat brain opiate receptors].

Stereospecific binding of apomorphine to rat brain opiate receptors was shown by assaying the competition of 7,8(n)--3H--naloxone and D-ala2-tyrosyl-3,5-3H--enkephalin (5-D-leucine) for opiate receptor binding. EC-NaCl50, the concentration of apomorphine which inhibited 50% binding of the radioactive naloxone and D-ala2, D-leu5-enkephalin in the absence of NaCl were 20 and 42 microM, respectively. EC+NaCl 50, the concentration of apomorphine which inhibited 50% binding of the radioactive naloxone in the presence of 100 mM NaCl was 17 microM. From the ratio of EC+NaCl 50 to EC-NaCl the value of "sodium shift" of effective concentration can be calculated as 0.85. From the data obtained it is concluded that apomorphine, like naloxone, is a "pure" antagonist but it has much less affinity for enkephalin and opiate binding sites. The probable mechanisms of the pharmacological action of apomorphine are discussed.

Animals↗
PubMed1979

[Pathomorphosis of reactive psychoses].

Comparative clinicostatistical, epidemiological and catamnestic investigation was carried out in two groups of patients with reactive psychoses (a total of 982 subjects) recorded at medico-legal expert testimony in 1950--1960 (I group) and in 1961--1972 (II group). It was found that in the recent decade reactive psychoses are rarely transformed and course in the presence of less vitalistic affective disorders with a tendency to increasing hysterical symptoms; the relapses are not rather long and severe, and they lead to postreactive psychic changes less frequently. It is suggested that reactive psychoses are subject to essential pathomorphism which has clinical importance and optimistic prognosing.

Asthenia↗
PubMed1978

[Treatment of reactive stuporous states with L-DOPA].

The paper presents the results of L-dopa use for the treatment of patients with reactive stuporous states. The assumption concerning curability of these patients is based on the similarity of a number of their clinical and biochemical manifestations with an akynetic-rigid form of parkinsonism where L-dopa is very effective. From 25 patients with reactive psychoses 7 demonstrated recovery, 3 patients--significant improvement, 5 patients--improvement and 10 patients--absence of the effect. The drug is the most effective in the stuporous depth of psychomotor inhibition in persons with a monomorphic structure of stuporous syndromes, rather "frequent" depressive disorders and a decrease of a background level of dopamine excreation with urine. Use of L-dopa in schizophrenic stuporous states (5 patients) was ineffective.

Adult↗
PubMed1975

[Effect of the psychogenic factor on the clinical picture and course of schizophrenia].

The role of a psychic trauma depends upon the stage and course of schizophrenia. It can give a shade of reactive psychosis to the initial stage. The role of the psychogenic factor is still more apparent during the advanced stages of schizophrenia in a torpid course of the disease where it can cause exacerbation of the main symptoms, short-term excitatory hysteriform reactions, depressive or depressive-paranoid states partly reflecting the stress provoking situation. During the remission psychic trauma is usually responsible for the exacerbation of schizophrenic symptoms and the subsequent structural changes of the original defect. Thus, psychic trauma interacts with endogenous factors and influences the whole stereotype of the disease development.

Bipolar Disorder↗
PubMed1975

[Clinical patterns in the course of alcoholic psychosis].

A dynamical study of 266 patients with alcoholic psychoses during a long period, demonstrated that the traditional classification according to the syndromological principle is not adequate to the modern development of psychiatry. The achieved clinical data testify to the fact of an existence of 3 main types of alcoholic psychoses: episodic, remittent and protracted. An analysis of the clinical picture of alcoholic psychoses from the point of view of "psychiatry development" permits to claim that there is a unity of the pathogenetical mechanisms of all the psychotic conditions in a chronic alcoholic intoxication. The main pathogenetical factors conditioning the type of psychoses is the stage of alcoholism and the character of alcholic abuse.

Chronic Disease↗