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Biomedical subjects

G Ugolotti

Publications and source records attributed to G Ugolotti.

At least 37 records · Page 2Linked to original sources
PubMed1984

Antimuscarinic compounds and gastric kinetics: a study with pirenzepine on healthy subjects.

A study has been made on the modifications that appear after acute dosage of pirenzepine in a series of eight healthy subjects of both sexes who had shown, by radioisotopic evaluation, a physiological pattern of gastric kinetics. The acute dosage of the drug was continued for three days at therapeutic doses and, a few hours after the last administration, the same study was repeated. As a test meal, a whole fried egg containing 99mTc-labelled serum albumin was used. The kinetics of the gastric content was scanned by a gamma-camera. The difference in gastric kinetics between the baseline situation and that after administration of the drug is reported and discussed.

Adult↗
PubMed1982

Antiinflammatory drugs and gastric emptying. A comparison between acetylsalicylic acid and carprofen.

Continuing their studies of gastric emptying modifications induced by nonsteroid anti-inflammatory drugs, the authors investigated the effects of 6-chloro-a-methylcarbazole-2-acetic acid (carprofen, Imadyl) versus those of acteylsalicylic acid (ASA) in an open crossover study of 10 healthy volunteers with normal gastric motility. The subjects received a standard meal labeled with 99Tc DTPA and were monitored for gastric emptying over time by scintiscanning with a gamma ray camera wired to a computer. Each subject was examined in basal conditions and after dosing with carprofen and ASA in random sequence with a 10-day washout period between tests. With the ASA treatment, all subjects showed considerable prolongation of gastric transit compared to pretreatment values, both in terms of first discharge of labeled bolus into the duodenum and of percent gastric radioactivity dissipated at 20 min. With carprofen, both parameters were influenced in the same direction to a significantly lower degree, to the point where the difference from pretreatment values was statistically improbable.

Adult↗
PubMed1981

[Selective coronary scintiscanning].

30 patients, undergoing coronary angiography for diagnostic and/or bypass surgery evaluation, have been studied also by intracoronary scintigraphy (IS). Scintigraphic and angiographic data have been compared: --21 cases had concordant results: normal in 2 patients (quite normal coronary system); pathological in 19, accounting for a damage both of the principal coronary artery branches and the arteriolar-capillary system: --6 cases had a pathological angiography with a normal IS: an indication of a normal myocardial perfusion; --in 3 cases a normal angiography was coupled with a pathological IS, pointing out a damage of the arteriolar-capillary system. On the basis of these results and of the literature, the AA. emphasize that the IS, allowing an exact evaluation of the myocardial perfusion, complete the essential morphological informations of the coronary angiography and it is specifically useful: --in the candidates to bypass coronary surgery; a viable myocardium is important both for surgery indication and results; --in bypassed patients to assess patency and the actual blood delivery (also for the low reliability of e.v. Thallium); --in patients with typical angina and positive stress test but with normal coronary angiography, to establish an organic lesion of the arteriolar-capillary system.

Adult↗
PubMed1979

[Kinetics of the biliary system (author's transl)].

A dynamic study of the hepato-biliary system was carried out by means of HIDA-99mTc and of a gamma-camera. The study was performed in basal conditions and after administration of a fatty meal. Normal subjects and patients suffering from various diseases of the biliary system were examined. The method is simple and well tolerated. Three mechanisms are invoked and discussed concerning the kinetic reactions of the gall bladder and the biliary ducts.

Biliary Tract↗
PubMed1978

[Blind pouch after choledochoduodenostomy (author's transl)].

In order to define the role of the blind pouch as causal factor of late complications after lateral choledochoduodenostomy ("sump" syndrome), the Authors have reviewed 37 patients previously operated on for common duct stones and/or benign papillary stenosis. In 19 patients, clinical and laboratory data have been associated to cholangiography, barium meal and 99mTc HIDA hepatobiliary scanning. Although we considered a few cases, the results were satisfactory. Slight symptoms noticed in some patients do not derive from "sump syndrome", as proved by the lack of correlations between clinical results and roentgenologic and radioisotopic data.

Adult↗
PubMed1978

Thyroid and obesity: survey of some function tests in a large obese population.

Tests of thyroid function in 493 obese patients were compared with thyroid function in 3076 non-obese patients. No differences in 131I uptake by the thyroid were observed at 6 h or 24 h; the frequency distribution was gaussian or normal in both populations; the frequencies of normal, high or low T3 and T4 values in the two populations were likewise comparable. Further, no correlation was found in the obese subjects between 131I uptake (6 h and 24 h), T3, T4 and overweight; on the other hand, there was a significant negative correlation between 131I uptake (6 h and 24 h) and age. It would appear that thyroid function is normal in obesity.

Adolescent↗