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Biomedical subjects

G Tatra

Publications and source records attributed to G Tatra.

At least 55 records · Page 3Linked to original sources
PubMed1985

Circulating IgE levels in patients with gynecological tumors.

Serum IgE levels in 148 women with a histological confirmed genital cancer of different stage and site and from 23 patients with benign ovarian tumors were determined prior to therapy. For determination of IgE an enzyme-linked immunosorbent assay was used. Result obtained did not give evidence that circulating IgE levels are different to healthy control subjects. Findings were not influenced by tumor-localization, by primary tumor or recurrence.

Aged↗
PubMed1985

Low antithrombin III and high plasma fibronectin in pre-eclampsia.

Antithrombin III activity and plasma fibronectin levels were determined in patients with preeclampsia. In several cases low antithrombin III and high plasma fibronectin concentrations could be related to proteinuria. Altered plasma fibronectin and antithrombin III concentrations might contribute to a hypercoaguable state in patients with preeclampsia.

Adolescent↗
PubMed1985

[Do pregnancy proteins have prospective significance? (SP-1, HPL and PP-5)].

Concentrations of pregnancy proteins were determined in blood of 219 pregnant women in 20th week of gestation. Pregnancy-specific beta 1-glycoprotein SP-1, human placental lactogen (hPL) and placental protein 5 (PP-5) were tested. In contrast with results of other authors there were no differences between the normal group of patients and those with complications during gestation, such as prematurity and foetal retardation. Thus measurement of blood concentration of proteins mentioned above in 20th week is not of prognostic relevance for gestation.

Female↗
PubMed1985

[Acute-phase markers in gynecologic tumors].

The serum concentration of 3 acute phase reactants (APR) (Caeruloplasmin, Alpha-1-antitrypsin and C-reactive protein) was measured by Mancini-technique praetherapeutically in a group of 214 patients with different sites of gynecological tumors. A group of 27 healthy women was used for comparison. In benign tumors Caeruloplasmin had in cases of myoma significantly (5%-standard) more elevated levels than normal group. In all cases with malignancies all 3 APR had significantly more elevated levels than in benign tumors. In cases of carcinoma of ovary all 3 APR had significant more elevated levels than benign ovarian tumors. The percentage of praetherapeutically elevated Alpha-1-antitrypsin levels was higher, while the percentage of elevated CRP-levels in cases with benign ovarian tumors ("false positive") was lower in comparison to accepted markers for ovarian cancer. Thus it appears to be indicated to prove the value of measurement of APR for monitoring in gynecological oncology.

C-Reactive Protein↗
PubMed1984

[Rectal sonography--an expansion of the diagnosis of recurrent cervical neoplasms].

Rectal sonography--especially with the use of modern rotating scanners--provides major progress in the diagnosis of recurrent malignant tumours in the lower pelvis. Due to the high resolution and the possibility of exact localisation this method is less biassed, and hence rectal scanning can be used as a routine method in future in cases suspected of recurrences located at the pelvic wall. Sonography in general and its advantages are discussed in comparison to other techniques for the diagnosis of recurring cervical malignancies.

Diagnosis, Differential↗
PubMed1984

[Changes in the clinical picture, morphology and therapy of endometrial carcinoma over 3 decades].

In the years 1952 to 1980 724 women were treated at the 2nd Department of Gynecology and Obstetrics, University of Vienna, for carcinoma of the endometrium. The mean age of the 463 (64%) women operated on rose from 56 to 62 years within three decades; the mean age of the 254 (35%) patients who received primary radiation therapy rose from 68 to 72 years; 7 women (1%) were treated symptomatically only. Looking at constitutional factors an increase of the number of women with manifest diabetes from 4% to 22% was noticed above all. Body weight and mean blood pressure increased slightly although not significantly. Irregular bleeding was the most common symptom, occurring in 90% of all cases and did not show any change in frequency. During the first decade of the period under consideration 86% of the women underwent primary operation, but that percentage decreased to 51% after 1970. Equally distinct was the decrease of 34% to 4% of the vaginal in favor of the abdominal operation. The number of cases with carcinomas with deep myometrial invasion and low differentiation increased. The high significance of these parameters for prognosis is shown by survival curves. The 5-year survival rates of patients primarily operated were about 75%, that of women receiving primarily radiation therapy at about 54%. These results remained approximately the same within the observation period. The increase of complicating factors such as higher age and more frequent incidence of diabetes mellitus accounts apparently for the increase in the number of women receiving primary radiation therapy.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1983

[Plasma fibronectin in normal pregnancy and EPH gestosis].

Plasma fibronectin was determined during normal pregnancy after 15th week, post partum, in cord blood and in cases of EPH gestosis. Non-pregnant women of a comparable age group were examined for plasma fibronectin concentration. Fibronectin at the end of gestation was at about the same level as at the beginning of the second trimester and as in non-pregnant women. The amount of fibronectin remains post partum practically the same. Cord blood fibronectin was about half the concentration of that in adult plasma. In EPH gestosis, levels were significantly elevated.

Adolescent↗
PubMed1983

[SP-1 in normal and complicated early pregnancy. Diagnosis by enzyme immunoassay].

Pregnancy specific glycoprotein SP-1 was measured by enzyme immunoassay Enzygnost in patients with diagnosis of haemorrhage in early pregnancy. Results were compared with a normal range between 6.-22. week of gestation (n = 268) and were analysed for their predictive value in determining prognosis. 24 of 27 cases with levels below the normal range had an abortion (88,9%) while 28 of 31 women with continuing pregnancies had levels within normal range (90,3%).

Abortion, Spontaneous↗
PubMed1983

[Plasmafibronectin in case of tumors of the female genital system].

The plasma concentration of fibronectin was measured by method of single radial immunodiffusion pretherapeutically in a group of 72 patients with different sites and various stages of gynecological carcinomas and of 27 women with benign cysts of ovary. A group of 18 healthy women was used for comparison. Fibronectin in plasma was significantly decreased in patients with ovarian tumors while in patients with other tumor localizations no significant difference to control group was evaluable.

Adult↗
PubMed1982

The detection and measurement of oncodevelopmental proteins in gynecological malignant disease.

Data from the literature and our own measurements with alpha-fetoprotein (AFP), carcinoembryonal antigen (CEA), alpha 2-pregnancy-associated globulin (alpha 2-PAG), human chorionic gonadotropin (HCG), human placental lactogen (HPL) and pregnancy-specific beta 1-glycoprotein (SP-1) are related to clinical data. Only AFP in endodermal tumors and HCG in germ cell carcinomas can be used for clinical monitoring.

Carcinoembryonic Antigen↗
PubMed1982

[Clinical aspects and therapy in primary ovarian cancer].

The charts and the histological slides of 122 cases of ovarian cancer, treated at the 2nd Gynaecological Department, University of Vienna, in the years 1968 to 1977 were reexamined. The statistic evaluation were done by Pearson's correlations coefficient, the Breslow and Mantel test or the trend test after Tarone. Priority was given to the prognostic value of all the data gathered. Problems of presurgical diagnosis and symptoms were outlined. The 5 years survival rate was in stage I 73%, in stage II 25% and in stage III 5%. The survival curves of stage Ia and Ib did not show any differences wether the adnexa had been removed or total exstirpation had been performed. The presence of ascites however impaired the prognosis significantly. In almost all cases of stage II total exstirpation had been performed. In stage III no significantly different effects could be observed between "incomplete" surgery as probatoria, exstirpation of the inflicted adnexa and total exstirpation of the internal genitals. Therefore an additional total omentectomy seems to be obligatory for further improvement of survival curves. A significant improvement of the survival rates has been achieved by telecobalt irradiation.

Adult↗
PubMed1981

Pregnancy specific beta 1-glycoprotein and alpha 2-pregnancy associated globulin in tumours of the female genital tract.

Tumour tissues obtained from 35 patients with malignancies of the female genital tract were investigated for production of pregnancy specific beta 1-glycoprotein (PS beta 1G) and alpha 2-pregnancy associated globulin (alpha 2-PAG). PS beta 1G was found in all five trophoblastic tumours studied and in 10 of the 30 nontrophoblastic cancers. alpha 2-PAG was not detected in any of the neoplastic tissues. In 18 of the patients with non-trophoblastic tumours PS beta 1G and alpha 2-PAG serum concentrations were also determined. No correlation between serum and tissue findings were noted. Thus, PS beta 1G does not seem to be a valuable serum indicator for monitoring the extent or variation of tumour mass in nontrophoblastic gynecological malignancies. Likewise, alpha 2-PAG is unlikely to serve as a clinical useful tumour marker in various gynecological cancers.

Alpha-Globulins↗
PubMed1981

[SP-1 and beta-HCG in suspected ectopic pregnancy (author's transl)].

Serum levels of SP-1 and beta HCG as Trophoblastic Markers were measured in 31 women operated on suspected ectopic pregnancy. In all 24 patients with tubal pregnancy SP-1 levels estimated by enzyme immunoassay Enzygnost were higher than 5 ng/ml, whereas SP-1 levels in 7 cases with benign ovarian cysts were less than 2 ng/ml. Beta-HCG in serum was analysed by radioimmunoassay (Serono-Biodata): in cases with ectopic pregnancy serum levels were between 113 mIU/ml and 1040 mIU/ml, in the 7 nonpregnant cases the highest concentration was 7 mIU/ml. There was no correlation between serum concentration of SP-1 and beta-HCG (r = 0,571). In view of clinical practice preference is given to estimation of SP-1 by enzyme immunoassay over estimation of beta-HCG by radioimmunoassay, the reasons are discussed.

Chorionic Gonadotropin↗
PubMed1981

[Behavior of the serum concentration of pregnancy associated alpha 2 glycoprotein (alpha 2-PAG) in gynecologic carcinomas (author's transl)].

The serum concentration of Alpha 2-PAG was measured in a group of women (n = 204) with different sites and types of gynecological carcinomas and various stages. In a follow-up study over a period of 2 years a positive correlation between Alpha 2-PAG serum concentration and clinical course was found in 50 of 139 woman (35.9%) only. These results suggest that Alpha 2-PAG is an unsatisfactory marker in a majority of the gynecological malignomas studied.

Female↗
PubMed1980

[Serum concentration of pregnancy-associated alpha 2-glycoprotein in cervical cancer (author's transl)].

The serum concentration of pregnancy-associated alpha 2-glycoprotein (alpha 2-PAG) was determined over a period of up to two years in a group of 77 women with carcinoma of the cervix of different staging. A positive correlation was found between the serum alpha 2-PAG level and the clinical course of the disease in only 31 patients (40.3%). It is concluded that measurement of the concentration of alpha 2-PAG in serum is unlikely to be useful as a means of evaluation of the clinical progress.

Female↗