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Biomedical subjects

G T Craig

Publications and source records attributed to G T Craig.

33 records · Page 2Linked to original sources
PubMed1984

An investigation of the role of true hypha production in the pathogenesis of experimental oral candidosis.

From 427 cases of human oral candidosis 2135 yeast clones were screened for the presence of germ tube-negative C. albicans and variants that formed only pseudohyphae in serum; one strain of each was found. The pathogenic potential of the serum-pseudohyphal and germ tube-negative C. albicans variants was investigated in the oral cavity of the rat; both variants failed to induce palatal candidosis, in contrast to a germ tube-positive C. albicans control strain. The pathogenic potential of C. albicans strains appears to be dependent on the formation of true germ tubes.

Animals↗
PubMed1980

Dermoid cyst of the mandible.

A mid-line cyst of the mandible is described which possessed the histological features of a dermoid cyst. This appears to be the first fully documented example of a totally intra-osseous dermoid cyst in the mandible. The pathogenesis of the present lesion is discussed in relation to both the odontogenic and the non-odontogenic cysts that may occur in the mandibular mid-line.

Adult↗
PubMed1980

Stereological analysis of hamster cheek pouch epithelium after one application of DMBA or turpentine.

Both cheek pouches of two groups of five male hamsters were treated with one application of either 50% turpentine in liquid paraffin (TLP50) or a 0.5% solution of dimethylbenz(alpha)anthracene in liquid paraffin (DMBA); animals were killed 48 h later. Five untreated animals served as controls. Mucosal specimens were removed from each pouch, fixed in normal-acetic-alcohol and processed for light microscopy. Sections were cut at 4 micrometer and stained with haematoxylin and eosin. A systematic random sampling method was used to obtain sections for sterological analysis. Grids for point and intersect counting were superimposed on the projection screen of an automatic sampling microscope. Results showed that the epithelial nuclear-cytoplasmic ratio, nuclear density, nuclear diameter and surface area interface ratios were similar for the experimental groups and, with the exception of the last parameter, differed significantly from controls. The volume proportion of TLP50-treated epithelium was significantly larger than that of DMBA-treated epithelium. Derived values for the average nuclear volume in both experimental groups were almost twice that of controls; the cytoplasmic volumes were more than doubled. At 48 h the epithelial response to a single application of TLP50 or DMBA was essentially similar except that TLP50 probably induced greater hyperplasia.

9,10-Dimethyl-1,2-benzanthracene↗
PubMed1979

Disseminated histoplasmosis presenting with oral lesions - report of a case.

A case of disseminated histoplasmosis is presented in which the initial diagnosis was made on the histology from oral lesions. The clinical and microscopical differential diagnoses are discussed. Including the present case, 12 of the 13 subjects with disseminated histoplasmosis initially diagnosed in Great Britain have given a history of residence in an area where the disease is endemic. Many years of good health may intervene between the original infection and its subsequent reactivation. A diminished cellular immune response may precipitate this reactivation but could also facilitate the possibility of exogenous reinfection. The literature is reviewed.

Diagnosis, Differential↗
PubMed1979

Quantitative analysis of histological parameters in giant cell lesions of the jaws and long bones.

Stereological techniques have been used to compare histological parameters of the giant cell component in 10 giant cell tumours of long bones, 10 central giant cell granulomas of the jaws and 10 peripheral giant cell granulomas of the jaws. The giant cell parameters investigated were: mean profile diameter, mean diameter, mean profile axial ratio, volume-to-surface ratios, nuclear numerical density, profile area and cell volume. Serial sections were cut at 4 micron from routinely fixed, paraffin-embedded specimens of each case and two sections, separated by 100 micron, were stained with haematoxylin and eosin. Random fields were photographed until at least 25 giant cell profiles had been recorded from each of the two sections of each lesion. The processed film was projected for point and intersect counting, the entire procedure ensuring double-blind assessment of the cases under investigation. In general there was no significant difference for any of the parameters between the giant cells of central and peripheral jaw lesions. There was a significant difference, however, between the giant cells of central jaw lesions and long bone tumours in respect of both nuclear numerical density and mean absolute cell volume.

Adolescent↗
PubMed1977

The effect of turpentine on hamster cheek pouch mucosa: a model of epithelial hyperplasia and hyperkeratosis.

Hamster cheek pouches were painted thrice weekly with 50% v/v turpentine in liquid paraffin over periods ranging from 1 day to 16 weeks. Pouch mucosa was examined histologically for changes and measurements of epithelial thickness were made with a calibrated eyepiece micrometer. An increase in epithelial thickness was first observed 48 hrs. after a single painting and was accompanied by inflammatory changes in both epithelium and connective tissue. Maximal epithelial thickening occurred after 9 weeks of thrice weekly painting. Cheek pouches of animals left without further treatment for up to 1 year following 9 weeks painting were indistinguishable from controls. The epithelial response to treatment with turpentine is that of a reversible benign epithelial hyperplasia with hyperkeratosis.

Animals↗
PubMedDate not supplied

A radicular dens invaginatus.

A case of the radicular type of dens invaginatus involving a mandibular third molar is reported. The clinical presentation and histopathology are described and the development and significance of such lesions discussed.

Adult↗
PubMedDate not supplied

Bone healing following the use of hydroxyapatite or ionomeric bone substitutes alone or combined with a guided bone regeneration technique: an animal study.

The healing of standardized bone defects grafted with either particulate ionomeric or hydroxyapatite bone substitutes was compared in the mandibular ramus of 30 Sprague-Dawley rats. The possible additional response achieved when combining these materials with a guided bone regeneration (GBR) technique was also evaluated. Three groups of 10 animals received either no implant material or ionomeric or hydroxyapatite bone substitute in defects in the right ramus. The left mandibular defects received the same treatment, except that the operation site was covered by a membrane (GBR technique). Half of the animals were sacrificed at 4 and 10 weeks following surgery, and the inflammatory response at the implant site and the amount of new bone formed in the defects were determined histomorphometrically. Defects implanted with ionomeric bone substitute exhibited more bone formation (4 weeks = 3.19 +/- 0.35 mm2, 10 weeks = 5.35 +/- 0.26 mm2) than both defects that received no treatment (4 weeks = 0.88 +/- 0.35 mm2, 10 weeks = 2.1 +/- 0.49 mm2), membrane alone (4 weeks = 1.21 +/- 0.05 mm2) or hydroxyapatite bone substitute (4 weeks = 1.41 +/- 0.46 mm2, 10 weeks = 3.34 +/- 0.41 mm2) at 4 weeks (P < or = .01) and at 10 weeks (P < or = .05). The use of a GBR technique did not increase the amount of bone formed, compared to the use of bone substitutes alone. Hydroxyapatite and ionomeric bone substitutes used alone were more effective in inducing repair of the defects than was GBR membrane alone. The use of hydroxyapatite was associated with a greater inflammatory reaction (P < or = .01) than was ionomer in this model.

Analysis of Variance↗