Search PubMed⌕ Search

Biomedical subjects

G Soubrane

Publications and source records attributed to G Soubrane.

At least 127 records · Page 7Linked to original sources
PubMed1985

Influence of pregnancy on the evolution of background retinopathy. Preliminary results of a prospective fluorescein angiography study.

Previous reports have suggested that pregnancy does not influence the development of diabetic retinopathy. Since 1979 a prospective study using fluorescein angiography has been in progress. Preliminary results include 22 diabetic women with or without moderate background retinopathy studied until delivery. They were maintained under good metabolic control (mean HbA1: 7.68%). Five clinical and fluorescein angiography examinations were performed at prefixed intervals (before the 15th week, at the 28th and 35th weeks of pregnancy, and 6 and 15 months after delivery). The analysis of fluorescein angiography which did not induce any side effect showed that the mean number of microaneurysms increased from 42.7 before pregnancy to 56.7 at the 28th week and to 79.7 at the 35th week. Six months later the number was 62.7, and 15 months later 60.3, still higher than at the initial examination. This study suggests that pregnancy has an unfavourable influence on the background retinopathy in diabetic patients even when a good metabolic control is achieved and retinopathy is minimal.

Adult↗
PubMed1984

[Toxoplasmic choroiditis and subretinal neovessels].

Thirty six cases of toxoplasma chorioretinitis with fundus scars were studied. Subretinal neovascularization occurred in 7 cases out of 36. Angiographically, the new vessels were located either directly on the border of scar (5 cases) or at distance with feeder vessels arising from the scar. The identification of subretinal new vessels is easy during the early phase of angiography. At the late phase, the leakage from the membrane is usually difficult to distinguish from the staining of the scar. Leakage from these new vessels can cause a sudden decrease of visual acuity (from 0.4 to central scotoma) that is not associated with inflammatory signs. The natural history of these juxtafoveolar new vessels allows a useful final acuity (0.18 after a follow-up period from 5 to 42 months). The visual outcome of toxoplasmosis choroiditis without subretinal new vessels is usually around 0.5. In 3 eyes photocoagulation of new vessels was performed with improvement in the mean final acuity (0.3). In our cases the occurrence of subretinal new vessels happened only when the healing process was achieved, from 1 to 26 years after the acute chorioretinitis.

Adolescent↗
PubMed1984

[Effects of red krypton and monochromatic green argon lasers in the foveal region. A clinical and experimental study].

The destruction of senile neovascular membranes in the central avascular region of the macula using argon laser is difficult and associated with complications. Yellow pigment in this region absorbs the blue component of the conventional argon laser radiation. In this study, we compared laser of different wavelenghts: red krypton and green argon. Light and electron microscopic studies on non-human primates were performed at one hour and three weeks following laser burns. With the red krypton laser maximum damage was seen at the level of choriocapillaris and the choroïd, although the pigment epithelium was also destroyed. With the green argon laser the maximum absorption occurred at the level of the pigment epithelium. A clinical and angiographic study showed that the destruction of juxtafoveal neovascular membranes by both these lasers was possible after one or several treatment sessions. After an average follow-up period of 45 months, visual acuity was stable or improved in 10 out 17 eyes treated with the green argon laser and in 27 out of 53 eyes treated with the red krypton laser. Our results suggest that the red krypton laser offers a better alternative for the treatment of neovascular membranes located near the foveola since less unnecessary damage is induced. Outside the xanthophyllic area there is no major difference between the different wavelengths.

Animals↗
PubMed1984

[Angiographic aspects of senile macular degeneration: spontaneous course].

Between 1971 and 1981, 45 patients (50 eyes) with a senile macular degeneration were seen at an early stage of the disease. These patients were followed for 6 to 72 months (mean follow-up 32 months). The early morphological features and evolution of the lesions were analysed by fluorescein angiography. Three different angiographic types of subretinal new vessels were identified in this study. These were: angiographically visible vascular networks (27 cases) subretinal new vessels hidden behind retinal pigment epithelium modifications (9 cases); and subretinal new vessels associated with pigment epithelial detachment (14 cases). In the first group subretinal new vessels were clearly visible on the angiogram, as a distinct network of cart wheel-like capillary plexuses which fill very early in the arterial phase. Progressive leakage of dye hides this capillary plexus during the late phase. In the second group a pigment epithelial detachment, usually identified on biomicroscopic examination, was associated with neovascularization visible as a hyperfluorescent hot spot or as an uneven hyperfluorescence on the border of the RPE detachment. Other angiographic features are a non-circular shape, irregular filling of the pigment epithelial detachment, and uneven late hyperfluorescence. In the third group, occult neovascularization was usually located behind the retinal pigment epithelium. When subretinal neovascularization was suspected by the presence of a disciform lesion, angiography, showed an irregular pattern of delayed hyperfluorescence with late leakage. These features permit putative diagnosis without precise localization. This clinical study attempted to establish the evolution and prognosis of three clinical forms of subretinal new vessels, in order to more accurately establish the indications of photocoagulation treatment.

Aged↗
PubMed1984

[Indications, technics and results of argon laser photocoagulation of macular subretinal neovascularization].

New vessels in senile macular degeneration threaten central vision. To evaluate the effects of treatment a randomized prospective trial was undertaken between 1977 and 1981. This trial concerned destruction of subretinal new vessels by argon laser photocoagulation. The indications of photocoagulation depended on the location of new vessels in relation to the center of the fovea. New vessels amenable to this treatment were those that were clearly visible on angiography and located farther than 100 microns from the foveola. 60 patients were divided into 3 groups according to the distance of the new vessels from the fovea: 100-200 microns away; 200-400 microns away; and greater than 400 microns away from the center of the fovea. In each group patients were randomly assigned to treatment or no treatment. After at least one year follow-up, argon laser showed a statistically significant effect (p less of 0,01; Kolmogorow-Smirnov test) on the stabilization or the amelioration of visual acuity compared with the non treated group. There was no statistical difference in the 3 groups of new vessel location. In cases of failure, no differences in final visual acuity existed between the treated and the non-treated group.

Aged↗
PubMed1983

The effects of red krypton and green argon laser on the foveal region. A clinical and experimental study.

The destruction of senile neovascular membranes in the central avascular region of the macula by argon laser is difficult and associated with complications. Yellow pigment in this region absorbs the blue component of the conventional argon laser radiation. In this study, the authors used lasers of different wavelengths: red krypton and green argon. Optical and electron microscopic studies on nonhuman primates were performed at 1 hour and 6 weeks. Maximum damage was seen at the level of the internal choroid with krypton laser and at the level of the pigment epithelium with green argon laser. A clinical and angiographic study showed that the destruction of the juxtafoveal neovascular membranes by both lasers was possible. Our clinical experience suggests that the red krypton laser offers a better alternative for treatment of neovascular membranes located near the foveola than the green argon laser.

Animals↗