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G Soubrane

Publications and source records attributed to G Soubrane.

At least 109 records · Page 6Linked to original sources
PubMed1990

Safety of fluorescein angiography during pregnancy.

We sent 424 retina specialists questionnaires on fluorescein angiography performed on pregnant women; 399 specialists responded. Of these, 309 (77%) had never performed fluorescein angiography on a pregnant woman. Ninety specialists (23%) had performed at least one fluorescein angiogram on a pregnant woman; detailed information was obtained on 105 patients. Authors of previous reports that included fluorescein angiography during pregnancy provided information about an additional 11 patients. Substantiated side effects were nausea or vomiting in seven patients. Anomalies at birth, an undescended testicle and syndactyly, were reported in two children. There was one stillbirth with pathologic findings classic for toxemia, and one fetal death occurred several months after fluorescein angiography. One therapeutic abortion was performed for complications in toxemia. One spontaneous abortion occurred three days after fluorescein angiography in a patient who was four weeks pregnant. Eight children born to toxemic mothers had low birth weights. We conclude that fluorescein angiography does not cause a high rate of birth anomalies or complications during pregnancy.

Abnormalities, Drug-Induced↗
PubMed1990

Late developing lesions in birdshot retinochoroidopathy.

Birdshot retinochoroidopathy is characterized by depigmented spots radiating from the optic disk in association with mild vitritis, retinal vasculitis, and involvement of the optic nerve head. In two patients, we traced the long-term course of uveitis with vitritis, retinal vasculitis, and papillitis that resulted in the typical cream-colored spots of birdshot retinochoroidopathy after seven and eight years, respectively, of follow-up. These observations suggest that in long-standing inflammation of the retinal vasculature and uveal tract, the HLA-A29 antigen should be assessed, because the development of typical lesions of birdshot retinochoroidopathy may be delayed in some patients.

Adult↗
PubMed1990

The pretear characteristics of pigment epithelial detachments. A study of 40 eyes.

Retinal pigment epithelial tears are a major complication of pigment epithelial detachment (PED) in the elderly. We observed the pretear process of PED in 38 patients (40 eyes) to identify characteristic angiographic changes. Before the tear occurred, the filling pattern of the PED underwent alterations, including an increase in the size and a modification in the shape of the PED (27 eyes); the development of notches (14 eyes); and the onset or increase of subretinal fluid, hard exudates, and/or hemorrhages (30 eyes). The most noteworthy feature was the uneven filling of the PED, with a remarkably hypofluorescent central area that remained dark until the late angiographic frames (24 eyes). Conversely, hyperfluorescence appeared early at the margins of the PED, increased progressively, and sometimes demonstrated a crenated edge. The high risk of tearing indicates that laser treatment of the retina should be considered carefully in the presence of these angiographic features.

Aged↗
PubMed1990

Occult subretinal new vessels in age-related macular degeneration. Natural History and early laser treatment.

Little information is available on the natural history and no data have been published on laser treatment for occult neovascularization in age-related macular degeneration. The visual and angiographic outcomes were analyzed in 156 patients (82 untreated eyes; 81 treated eyes) with occult neovascularization who were followed for 1 to 8 years. Early laser treatment decreased visual acuity to less than 20/200 in 31 of the treated eyes (38%) compared with 20 of the untreated eyes (25%). Three years after the onset of symptoms, 24 treated eyes (29%) and 31 eyes untreated eyes (38%) retained 20/50 visual acuity or better, whereas their respective initial visual acuities were not statistically different. Severe loss of vision (6 or more lines of visual acuity) occurred in 43 treated eyes (53%) and in 33 untreated eyes (40%) at the end of follow-up (range, 12-84 months). A slow and gradual increase of the disciform lesion was demonstrated on fluorescein angiography in 60 untreated eyes, with subfoveal involvement noted in 39 eyes at the end of follow-up. In the treated group, subfoveal involvement occurred in 53 eyes, after a relatively short time (mean, 4 months). Only 28 of the 81 treated eyes had successful anatomic results. These findings suggested that laser treatment of occult neovascularization immediately after the onset of symptoms should not be recommended.

Aged↗
PubMed1990

Binding of basic fibroblast growth factor to normal and neovascularized rabbit cornea.

The labeling pattern of frozen sections of rabbit cornea incubated with radioiodinated basic fibroblast growth factor (bFGF) was investigated in normal corneas and prostaglandin-induced neovascularized corneas by autoradiography followed by image analysis. 125I-bFGF binds to Bowman's, Descemet's, and vascular basement membranes in a dose-dependent manner. The specificity of the binding of bFGF to basement membrane was demonstrated by the following experiments: 1) an excess of unlabeled growth factor displaced the labeling; 2) histones did not modify the labeling; and 3) 2 M NaCl washing and enzymatic treatment with heparitinase prevented binding of labeled growth factor without apparent destruction of the overall structure of the basement membrane. Our results suggest that bFGF binds to the heparan sulfate proteoglycan of basement membranes. Both normal limbal vessels and the newly formed corneal vessels exhibited the same type of labeling but with different intensities, according to the degree of maturation of the new vessels. bFGF binding also is located clearly on the endothelial cells in both types of vessels. This second binding site could correspond to the high affinity receptors on the cell surface and suggests a direct interaction of bFGF with endothelial cells during new vessel formation.

Alprostadil↗
PubMed1990

[Macular vitelliform degeneration in adults. Retrospective study of a series of 85 patients].

Since 1974 (Gass), many publications have referred to a macular abnormality that is similar to Best's vitelliform dystrophy, but occurs in adults and shows a normal or subnormal electro-oculogram. In our retrospective study, 85 patients with adult macular vitelliform degeneration were included; 31 patients out of 85 have been followed-up for periods ranging from one to ten years. Women (62,3%) were predominantly affected; the median age was 61 years (ranging from 37 to 81 years); family history did not reveal others affected members except in one case (mother and her son affected); electro-oculogram was recorded in 12 patients and was normal (8 patients) or slightly subnormal (4 patients). During follow-up, vitelliform lesions have shown progressive changes over many years, resulting in a round or oval atrophic area in the central retinal pigment epithelium. Visual acuity was fair at presentation but decreased progressively: at presentation, 43% of the eyes had visual acuity better or equal to 0.6; after 1 year, 59%; after 2 years, 28.5%; after 4 years, 20%, and only 8% of those followed-up for 10 years. Impairment of vision was usually related to alteration of the retinal pigment epithelium and macular atrophy, sometimes to subretinal neovascularization (14 eyes of 12 patients out of 157, or 15% of patients), or rarely to macular edema (2 cases). Several aspects of this disease are still controversial: firstly, the problem whether or not the disease represents a single nosological entity; secondarily its dominant inheritance. The analysis of our cases and of those already published seems to show that the macular changes observed are related to a single disease, well-defined by the epidemiology, the clinical aspects, the natural course. The late onset of the disease, the lack of constant familial involvement and the similarity with other retinal degenerative disorders seem to suggest that vitelliform macular lesions may represent a distinct subgroup of age-related macular degeneration, with a possible genetic predisposition.

Adult↗
PubMed1990

[Dye lasers: experimental histopathologic study of the effects of various wavelengths on the macular region].

Pathological experimental study of dye laser photocoagulation simulating the confluent treatment of subretinal new vessels in the macular area of a Macacas Cynomolgus monkey. 38 days after treatment the lesions become similar on the choriocapillaris and retinal pigment epithelium whatever the wavelength; the choriocapillaris is always occluded and the pigment epithelium destroyed. The internal limiting membrane is ondulated only with yellow and orange colors. These results are compared to those of similar experimental studies.

Animals↗
PubMed1989

[Macular degeneration related to age].

Age related macular degeneration (A.R.M.D.) is the first cause of registered blindness in the developed countries after the age of 50. The prevalence of the disease increases with age. Risk factors have been identified. The atrophic form of age related macular degeneration, the most frequent form, results in a moderate decrease in visual acuity. The neovascular form of A.R.M.D. is associated in natural history with a central scotoma within 2 years. The disease involves both eyes with time. Fluorescein angiography allows an accurate diagnosis in identifying the subretinal new-vessels, and their location. The efficiency of blue green argon photocoagulation has been demonstrated on visual acuity by randomised trials, when the new vessels extend at more than 200 microns from the center. For new-vessels closer to it, monochromatic wavelengths can achieve the destruction of the neovascularization. But, laser photocoagulation is not the treatment of the basic process of A.R.M.D.

Aged↗
PubMed1989

[Vitreous hemorrhage complicating age-related macular degeneration. Apropos of 18 cases].

Vitreous hemorrhage as a complication of Age-Related Macular Degeneration (ARMD) is not a frequent event: 19 cases (out of 18 patients) are reported, corresponding to 0.6% of the patients with ARMD seen in the Department of Ophthalmology of Créteil between January 1st, 1979 and December 31, 1986. The relation between ARMD and vitreous hemorrhage was easy to establish on fundus examination after the resorption of the hemorrhage. However, during the acute hemorrhagic phase, the diagnosis was helped by the other eye fundus examination: this second eye presented with ARMD lesions in 15 out of 18 cases (78.9%). The most challenging differential diagnosis was the choroidal melanoma, when a subretinal hematoma hindered all underlying structures. Vitreous hemorrhages originated generally from well developed subretinal new vessels (17 cases out of 19) arising from the choroid. A retinal pigment epithelium tear, spontaneous or secondary to photocoagulation, was suspected to be the cause of the vitreous hemorrhage in one eye. Finally drugs (3 cases) and systemic diseases (6 cases) seemed to play a role. Visual prognosis is poor in most cases, as the result of the destruction of the macular photoreceptors (six eyes only retained a visual acuity equal or better than 20/400). Laser photocoagulation of the subretinal new vessels was possible for 5 eyes and allowed stabilisation of visual acuity in 2 eyes and improvement in one eye. Vitreous hemorrhage cleared in 16 out of 19 during the follow-up period and vitrectomy was therefore not performed in our series and not indicated at early stages.

Aged↗
PubMed1989

[Treatment of subretinal neovessels in idiopathic recurrent multifocal choroiditis].

We have conducted a retrospective study about 25 patients who have presented subretinal neovascularization and idiopathic recurrent multifocal choroiditis. Final visual acuity level (mean 20/30) was almost the same as the pre laser treatment visual acuity level (mean 20/25) for a follow up of 12 months. We have also studied the main clinical, angiographic and serologic features of these cases of multifocal choroiditis.

Adult↗
PubMed1989

[The dye laser: experimental and clinical results in subretinal macular neovascularization].

The tunable dye laser provides now a large assortment of monochromatic wavelengths that allow selective targeting on individual tissues in the retina, according to in vitro studies showing extinction coefficient of ocular pigments (xanthophyllic pigment, rhodopsin, melanin, lipofuschin, hemoglobin) for different laser wavelengths. Confluent heavy and juxtafoveolar laser burns in eyes of cynomolgus monkeys showed, after 38 days, similar lesions in all the wavelength studied (green, red, yellow, orange) at the level of the choriocapillaris, Bruch's membrane, pigment epithelium and photoreceptor's layers. However, the inner retina layers were discretely more damaged with yellow and orange than with green and red. In clinical approach, the effects of these different wavelength haven been compared in human eyes presenting with subfoveol new vessels and disciform age-related macular degeneration. After healing, the scar was similar biomicroscopically, and on fluorescein angiography with all wavelengths studied (green, red, yellow, orange). In conclusion, dye laser seems to be efficient and easily tunable for photocoagulation in macular area.

Aging↗
PubMed1989

[Retinal pigment epithelial tears after photocoagulation in age-related macular degeneration].

Retinal pigment epithelial tears after photocoagulation for subretinal new-vessels complicating age related macular degeneration were observed in 20 patients between 1980 and 1988. The patients, 4 males and 16 females, aged from 60 to 86 years (mean: 72.5) were followed up between 12 and 53 months (mean: 21 months). Laser photocoagulation was performed for directly visible lacy subretinal new-vessels (6 cases) or vascularized pigment epithelial detachment (10 cases) or both lesions associated (4 cases). Krypton laser (17 cases), blue-green argon laser and/or orange dye laser (625 nm) (3 cases) were applied in one (9 cases) to four sessions. Retreatment (11 cases) was performed for persistent subretinal new-vessels (3 cases) or recurrences (4 cases) or appearance of a pigment epithelial detachment after photocoagulation for isolated SRNV (4 cases). The tear was observed on fluorescein angiography 10 to 180 days after the last session. It was preceded by occurrence of subretinal hemorrhages, increase in size of the PED or newly formed PED. It appeared on the border of the PED (16 cases) usually temporally, or on the immediate border of the laser scar (4 cases). Further evolution was rapidly defavorable with dramatic impairment of vision and constitution of fibrovascular scar in the macular area. Only 4 eyes progressed to flat atrophic scars after retreatment and retained useful central vision (0.1 to 0.2). Factors which could explain this complication following laser treatment of age related macular degeneration are discussed.

Aged↗
PubMed1989

[Macular holes].

Explore the source record for details and available documents.

Aging↗
PubMed1989

[Multifocal choroiditis: diagnostic aspects and results of photocoagulation. Apropos of 25 cases].

A retrospective study was conducted on 25 patients who presented with both recurrent multifocal choroiditis and subretinal neovascularisation. As in other series, striking features were the young age of the patients (mean age 33 years), frequent recurrences of the macular lesions during a limited follow-up period, inflammation of the vitreous or the optic disk, and macular fibrosis. However, unlike previously reported data, refraction was more often in the emetropic range, there was no female predominance, and inflammatory signs were mild or limited to papillitis. Moreover serologic tests did not indicate an acute infection due to Epstein-Barr virus in any of the patients. This study also emphasized the results of Krypton laser treatment of the subretinal neovascularisation. Final visual acuity improved or remain the same in 26 eyes (72%) and worsened in 11 eyes (28%) during a mean follow-up period of 13 months (range 2-48 months). The best results were obtained in 15 eyes with neovascular membranes located more than 200 mu from the foveal avascular zone (mean final visual acuity: 20/40). However the mean final visual acuity of the nine eyes with neovascular membranes closer than 200 mu from the FAZ, was over 20/60. Recurrences of subretinal neovascularisation occurred in 7 out of 24 treated eyes and 3 were under the center of the FAZ. These results should be confirmed by a randomized prospective clinical trial in order to assess the benefits of laser treatment in recurrent multifocal choroiditis.

Adult↗
PubMed1988

[Macular degeneration related to age and cystoid macular edema. Apropos of 95 cases (100 eyes)].

The leakage from the new vessels, responsible for the exudative form of age-related macular degeneration (ARMD), produces retinal detachment, haemorrhages, exudates and intraretinal cystoid macular edema (CME). In a retrospective study of 100 eyes, we assessed the prognostic value of cystoid macular degeneration of the inner retina. It was nos specifically linked to: 1 - the duration of the neovascular involvement; 2 - the extent of the neovascular membrane; 3 - the location of the new vessels; 4 - the type of the new vessels; definite (48 eyes) or occult (19 eyes), or advanced and fibrous lesions (21 eyes). However, cystoid macular edema was initially associated to legal blindness in 46% of eyes. Active SNV associated with CME were retrofoveal in 83% of the eyes. But biomicroscopical evidence of CME requires fluorescein angiography to identify the new vessels still amenable to laser photocoagulation. After a follow-up period ranging from 30 days to 6 years (mean 15 months), 69% of eyes were legally blind although 41 eyes were treated with laser photocoagulation (focal or perifoveolar). Thus, functional prognosis in ARMD is not uniquely and directly correlated with the presence of cystoid macular edema in ARMD.

Aged↗
PubMed1987

Adenocarcinoma of retinal pigment epithelium.

This report describes a 41-year-old man with an intraocular tumour misinterpreted clinically as choroidal melanoma. The fluorescein angiographic features were not fully characteristic of uveal malignancy, and indeed histopathology revealed the diagnosis of adenocarcinoma of the retinal pigment epithelium. It is suggested that, in cases with the fundus and angiographic findings described here, the rare possibility of adenocarcinoma of retinal pigment epithelium should be kept in mind. Of particular interest were the changing pathological findings in the various parts of the tumour, which paralleled the fluorescein angiographic pattern.

Adenocarcinoma↗