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Biomedical subjects

G Singh

Publications and source records attributed to G Singh.

At least 721 records · Page 40Linked to original sources
PubMed1984

Tumor associated antigen in ovarian carcinoma.

Tumor associated antigen present in the cyst fluid of a patient with papillary mucinous cytadenocarcinoma of the ovary was prepared by ammonium sulfate precipitation. The dialyzed precipitate was emulsified in complete Freund's adjuvant and injected into rabbits followed by booster doses of the antigen in saline. The resulting antiserum was absorbed with normal human serum and normal liver and AB type blood cells. The absorbed antiserum was found to react with mucinous cyst adenocarcinoma, borderline mucinous cystadenoma and gastric and rectal cancers by immunofluoresence and immunoperoxidase. No reactivity was noted by the same methods in serous-cystadenocarcinoma and mesonephroid tumors. The molecular weight of the tumor associated antigen in cyst fluid of a patient with mucinous cystadenocarcinoma was determined by Enzyme immunoassay and Gel filtration to be 450,000 daltons.

Antigens, Neoplasm↗
PubMed1984

Type II pneumocytes in pulmonary tumors. Implications for histogenesis.

Bronchioloalveolar carcinomas (n = 45), intravascular bronchiolo-alveolar tumors (n = 8), and sclerosing hemangiomas of the lung (n = 2) were stained for surfactant apoprotein by the immunoperoxidase method. Of the bronchiolo-alveolar carcinomas, 12 were found to be carcinomas of type II pneumocytes and the remaining 33 tumors were designated as nontype II pneumocytic bronchiolo-alveolar carcinomas. Twenty-five of these tumors displayed trapped benign type II pneumocytes within the tumor masses. In the case of intravascular bronchioloalveolar tumors, none of the tumors demonstrated staining of tumor cells for surfactant apoprotein. In the two cases of sclerosing hemangiomas, the type II pneumocytes were exuberant and numerous, and in one case contained intranuclear inclusions of surfactant apoprotein. This article discusses the implication of the presence of benign type II pneumocytes in pulmonary tumors.

Adenocarcinoma, Bronchiolo-Alveolar↗
PubMed1984

Iatrogenic central retinal artery embolization: a complication of cardiac catheterization.

A 57-year-old man with a myocardial infarction was subjected to cardiac catheterization as a follow-up study for his heart problem. The catheter, made for one time use only, was reautoclaved and used sometime before catheterizing this man. A small fragment of this catheter dislodged while guiding the parent catheter into coronary vessels with a metallic guide-wire. The fragment traveled getting lodged in the central retinal artery of the right eye leaving the eye with only light perception vision. The catheter fragment could be seen in the central retinal artery at the optic nerve head.

Cardiac Catheterization↗
PubMed1984

Bilateral deprivation amblyopia.

Two children had toxic bilateral cataracts at the ages of 36 months and 41 months and were deprived of treatment for the next 15 and eight years, respectively. After successful surgery the visual results were about 20/40 in both eyes. This visual recovery suggests that the susceptibility to bilateral stimulus deprivation at this age is slight but not absent, and furthermore that the longtime deprivation beyond the sensitive period does not effect greatly the ultimate outcome of the treatment. Absence of nystagmus supports the opinion that the visual motor system is mature by the age of 3 years.

Adolescent↗
PubMed1984

Bee sting of the cornea.

Irreversible heterochromia-iridis, internal ophthalmoplegia, and punctate subcapsular lenticular opacities developed in a 9-year-old girl after she received a bee sting in her right cornea. These complications persisted even after an 11-month follow-up period. To the author's knowledge, this presentation is the first of its nature. The pathogenesis of these changes is discussed and the literature is reviewed.

Bees↗
PubMed1983

Clinical and serologic study of Sjögren's syndrome in patients with progressive systemic sclerosis.

Fifty-eight patients with progressive systemic sclerosis (PSS) were evaluated clinically and by biopsy of the minor salivary glands of the lips for the presence of Sjögren's syndrome. Clinical findings included dry eyes in 38%, dry mouth in 32%, parotid enlargement in 4%, and an abnormal Schirmer's test in 34%. Histologic changes in lip biopsies included lymphocytic infiltrates characteristic of Sjögren's syndrome in 17 individuals (29%). In 19 (33%) there was periglandular and intraglandular fibrosis (PSS-fibrosis) without significant inflammation, an alteration characteristic of PSS per se. In the remaining 22 patients (38%) with PSS, no abnormality was found. Of those with PSS and Sjögren's syndrome, 53% had serum antibodies to SS-A and/or SS-B, while only 1 patient with a normal biopsy had either of these antibodies. Anti-SS-A and anti-SS-B were not detected in patients with glandular fibrosis alone. The mortality rate of the PSS-fibrosis group was higher due to a variety of severe internal manifestations related to PSS. Antibodies to SS-A and SS-B are useful serologic markers of the presence of Sjögren's syndrome in patients with PSS.

Adolescent↗
PubMed1983

Metabolism of amino acids in Ascaridia galli: transamination.

Ascaridia galli, using 2-oxoglutarate as an acceptor, transaminates alanine and aspartate at significantly high rates. Among other amino acids valine, phenylalanine, leucine, isoleucine, arginine, tyrosine and methionine are metabolised at moderate rates while lysine, serine, threonine, cysteine, glycine, histidine, tryptophan, DOPA and GABA appear to be inert in this respect. Body parts mimic the whole worm in the pattern of transamination of various amino acids with the exception of methionine. Alanine, aspartate and glutamate may transfer their amino group also to pyruvate and oxaloacetate. Alanine and aspartate: 2-oxoglutarate transaminases are located mainly in the cytosol and mitochondrial fractions.

Alanine↗
PubMed1983

Tissue and species specificity of an antiserum to human oral epithelial cells.

Antisera raised in rabbits against human gingival epithelial cells were examined for tissue specificity using an indirect fluorescent-antibody technique and tissues from human fetal, adult guinea-pig, rat and rabbit tissues. The antisera reacted with the intercellular material of stratified squamous epithelia and the basement membrane zone of a variety of tissues of the human and animal tissues examined. The basement membrane zone reactivity was ascribed to the presence of antibodies to fibronectin in the antiserum. The antisera reacted with the epithelial cells and Hassalls corpuscles of the fetal thymus but not with fetal thyroid tissue.

Animals↗