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Biomedical subjects

G Simu

Publications and source records attributed to G Simu.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Angio-immunoblastic lymphadenitis: remarks about two cases.

Two patients with clinical and pathological symptoms of so-called angioimmunoblastic lymphadenitis are presented. Both patients were over 50, with multiple lymphadenopathies, fever, pruritus and hyperglobulinemia. The lymph node changes exhibited a characteristic histological triad consisting of diffuse lymphoid proliferation, small arborizing vessels proliferation and paraamyloid-like amorphous material deposition. As previous authors suggested, the disease seems to be the expression of a prolonged hyperimmune response induced by the hypersensitivity to certain factors.

Anti-Bacterial Agents↗
PubMedDate not supplied

Lesions of the female genital tract in leukemia and lymphoma.

A pathological study was carried out on the female genital tract on specimens from 14 patients with leukemia or lymphoma. Marked lesions with microscopic alterations were found in chronic granulocytic leukemia and in histiocytic and mixed lymphomas, accompanied by clinical manifestations. The origin of the blastic elements is discussed.

Female↗
PubMedDate not supplied

The histopathological and immunohistochemical diagnosis in small cell lung carcinoma.

The small cells lung carcinoma (SCLC) represents 10-25% of the bronchogenical carcinomas, prevails at middle ages and is closely associated with tobacco smoke. It belongs to the group of carcinomas with neuroendocrine differentiation, the patients presenting various paraneoplastic syndromes. The study was performed on 491 patients with a clinical and radiological suspicion of bronchopulmonary cancer. In this study, the histopathological examination gives results similar to those mentioned in the medical literature for the small cells lung carcinoma, prevailing in the case of young patients. The immunohistochemical examinations are particularly precious in confirming the diagnosis, especially in the diagnosis of the lymphonodular micrometastases.

Adult↗
PubMedDate not supplied

Microscopic patterns in surgically removed spleens.

348 spleens surgically removed have been examined microscopically and classified into 3 groups: (I) 154 emergency splenectomies (86 traumatic ruptures, 44 enlarged supramesocolic exeresis, 44 cirrhosis), (II) 143 therapeutic splenectomies (135 cases of hypersplenism among which 10 apparently primitive, 7 myeloproliferative syndromes, 1 hairy cell leukemia), and (III) 51 diagnostic splenectomies (7 non specific inflammations, 2 tuberculosis, 1 mycosis, 6 echinococcosis, 12 leukemias, 9 non-Hodgkin's lymphomas, 13 Hodgkin's lymphomas, 1 primary splenic hemangioma). The study of the first group material, obtained especially of traumatic rupture, has been very valuable to follow the spleen microscopic structure in normal humans of different age. The latter two group cases have raised interesting problems of microscopic diagnosis, permitting at the same time a better understanding of the pathology of this organ.

Adolescent↗
PubMedDate not supplied

Case of biliary lithiasis in an infant.

The case of a 3-month-old premature infant deceased by massive hemorrhage from a giant hemangioma of the right thigh, exhibiting also biliary lithiasis, is discussed. The six dark-green-blackish faceted calculi contained by the gall bladder appear to be formed of biliary pigment and the consequence of repeated inflammatory hemolytic episodes in an immunodeficient infant.

Cholelithiasis↗
PubMedDate not supplied

Lymphoid changes suggesting escalation of immune response into malignant lymphoma.

The conditions in which the microscopic changes of the lymphoid organs, especially lymph nodes, render difficult the histologic decision of immune response or malignant lymphoma, are reviewed. The possibility that in certain circumstances, prolonged, pathologic immune response escalate to malignant lymphomas, as well as the new classifications of these diseases, in terms of this conception are discussed.

Diagnosis, Differential↗
PubMedDate not supplied

The significance of the lung biopsy in congenital cardiovascular malformations.

The microscopic changes of pulmonary arteries in 18 patients with congenital cardiovascular malformations were studied on lung biopsies and appreciated by the Heath-Edwards' scale. A correlation between the nature of the malformation and the patient's age on the one hand, and the severity of arterial lesions on the other hand, was observed, suggesting the utility of the lung biopsy for a better prognosis of the surgical corrective intervention. The role of inflammatory factors in the genesis of arterial changes leading to hypertension is also discussed.

Aging↗
PubMedDate not supplied

[An experimental study of the action of 5-fluorouracil on the function and cytomorphology of the exocrine pancreas].

The authors have taken up previous studies by Martin (1969), and by Johnson (1973), and carried out an experimental study on white rats aimed at evaluating the morpho-functional changes of cells from the exocrine pancreas under the influence of 5-fluorouracil (Ftorafur), a cytostatic drug which is a general inhibitor of protein synthesis by cells. Ftorafur was injected in amounts of 2.3 mg/100 g of body weight, and a significant reduction was noted in the secretion of bicarbonates, amylase and lipase by the pancreas of the animals. Cytologic changes were also noted in the pancreatic tissue of these animals, indicating, on the one hand, a deficient protein and enzyme synthesis by the pancreatic cells, and a blocking of the mechanism of discharge of zymogen granules, on the other hand. The most intensive morpho-functional changes were noted following repeated administration of Ftorafur, probably due to the cumulative effects of this substance at the level of secretory pancreatic cells. The authors consider that 5-fluorouracil inhibits to a considerable degree the synthesis of pancreatic enzymes, and as such it can be used as a therapeutic means for the reduction of the external secretion of the pancreas.

Animals↗